Serotonin 5-HT2A Receptor Antagonists
- Name
- Serotonin 5-HT2A Receptor Antagonists
- Accession Number
- DBCAT005168
- Description
Entities that are capable of exerting an antagonistic effect on 5-HT2A receptors.
- Drugs
Drug Drug Description Acepromazine Acepromazine was first used in humans in the 1950s as an antipsychotic agent. It is now rarely used in humans. Acepromazine is frequently used in animals as a sedative and... Amesergide Amesergide is a small molecule drug. Amesergide has a monoisotopic molecular weight of 393.28 Da. Amisulpride A dopamine D2 receptor antagonist used in the treatment of acute and chronic schizophrenia, and in the prevention and treatment of postoperative nausea and vomiting in adults. Amitriptyline A tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety. Amoxapine A tricyclic antidepressant used in the treatment of neurotic or reactive depressive disorders and endogenous or psychotic depression. Amperozide Amperozide is a diphenylbutylpiperazine atypical antipsychotic which antagonizes 5-HT2A receptors. It inhibits dopamine release and alters the firing of dopaminergic neurons. Investigations regarding the use of the agent revolved primarily... Aripiprazole An atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome. Aripiprazole lauroxil An antipsychotic used to treat schizophrenia in adults. Asenapine An atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia. Blonanserin Used for the treatment of schizophrenia . Brexpiprazole A serotonin–dopamine activity modulator used in the treatment of major depressive disorder as an adjunct, schizophrenia, and agitation associated with dementia due to Alzheimer’s disease. Bufotenine A hallucinogenic serotonin analog found in frog or toad skins, mushrooms, higher plants, and mammals, especially in the brains, plasma, and urine of schizophrenics. Bufotenin has been used as a... Butriptyline Butriptyline is a tricyclic antidepressant which has been used in Europe since 1974. It is the isobutyl side chain homologue of amitriptyline. Cariprazine An atypical antipsychotic used to treat schizophrenia and acute manic or mixed episodes due to bipolar I disorder. Carphenazine Used in the treatment of acute or chronic schizophrenic reactions in hospitalized patients. Chlorpromazine A phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. Chlorprothixene A thioxanthene antipsychotic. Cinitapride A benzamide with gastroprokinetic and antiemetic properties typically used for the treatment of gastrointestinal motility disorders such as gastroesophageal reflux disease (GERD), non-ulcer dyspepsia, and delayed gastric emptying. Clomipramine A tricyclic antidepressant used in the treatment of obsessive-compulsive disorder and disorders with an obsessive-compulsive component, such as depression, schizophrenia, and Tourette’s disorder. Clozapine An atypical or second-generation antipsychotic drug used in treatment-resistant schizophrenia and to decrease suicide risk in schizophrenic patients. Cyamemazine Cyamemazine (Tercian), also known as cyamepromazine, is a typical antipsychotic drug of the phenothiazine class used primarily in the treatment of schizophrenia and psychosis-associated anxiety. Cyamemazine actually behaves like an... Cyclobenzaprine A skeletal muscle relaxant that works on the brainstem to treat muscle spasms of local origin. Cyproheptadine A combined serotonin and histamine antagonist used in the treatment of allergic symptoms, for appetite stimulation, and off-label in the treatment of serotonin syndrome. Deramciclane Investigated for use/treatment in anxiety disorders. Desipramine A tricyclic antidepressant used in the treatment of depression. Dosulepin A tricyclic antidepressant commonly used only in patients for whom alternative therapies are ineffective due to its toxicity potential. Doxepin A psychotropic agent used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia. Droperidol A butyrophenone derivative and dopamine antagonist used to prevent and treat postoperative nausea and vomiting. Epinastine An H1 receptor antagonist used to prevent itching in allergic conjunctivitis. Esmirtazapine Investigated for use/treatment in insomnia and sleep disorders. Etoperidone Etoperidone has been studied for the treatment of depression , tremors in Parkinson, extrapyramidal symptoms and male impotence . It is not certain if it was ever approved and marketed... Fananserin Fananserin is a small molecule drug. The usage of the INN stem '-anserin' in the name indicates that Fananserin is a serotonin receptor antagonist. Fananserin has a monoisotopic molecular weight... Flibanserin A 5-HT receptor modulator used for the treatment of selected premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD). Flupentixol A thioxanthene neuroleptic used to treat schizophrenia and depression. Fluphenazine A phenothiazine used to treat patients requiring long-term neuroleptic therapy. Fluspirilene An antipsychotic agent used in the treatment of schizophrenia. Haloperidol An antipsychotic agent used to treat schizophrenia and other psychoses, as well as symptoms of agitation, irritability, and delirium. Iferanserin Iferanserin has been investigated for the treatment of Hemorrhoids. Iloperidone An atypical antipsychotic agent used to treat schizophrenia and manic or mixed episodes associated with bipolar I disorder in adults. Imipramine A tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis. Landipirdine Landipirdine is under investigation in clinical trial NCT02258152 (SYN120 Study to Evaluate Its Safety, Tolerability and Efficacy in Parkinson's Disease Dementia (SYNAPSE)). Lorpiprazole In 2016, lorpiprazole was classified in the "Chemical structure-related drug-like criteria of global approved drugs" as an antipsychotic and anxiolytic. An antipsychotic is a medication used to treat a state... Loxapine A antipsychotic used for the treatment of schizophrenia. Lumateperone A novel 2nd generation atypical antipsychotic used to manage schizophrenia, bipolar depression, and major depressive disorder. Lurasidone An atypical antipsychotic used to treat schizophrenia and depressive episodes associated with bipolar I disorder. Mesoridazine A phenothiazine antipsychotic used to treat schizophrenia, organic brain disorders, alcoholism, and psychoneuroses. Metergoline An ergot-derivative that acts as an antagonist at certain 5-HT receptor subtypes and as an agonist at dopamine receptors. It is often used in situations where inhibition of prolactin is desirable. Methotrimeprazine A phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder. Methysergide An ergot alkaloid used for the prophylaxis of migraine and cluster headaches. Mianserin A tetracyclic antidepressant with therapeutic activity similar to amitriptyline used to treat depression and anxiety. Milsaperidone An atypical antipsychotic used to treat adults with schizophrenia and manic or mixed episodes associated with bipolar I disorder. Minaprine For the treatment of depression Mirtazapine A tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite. Molindone An antipsychotic used to treat schizophrenia. Naftidrofuryl A peripheral vasodilator indicated in the treatment of chronic venous ulcers. Nefazodone An antidepressant used in the treatment of depression. Nortriptyline A tricyclic antidepressant used in the treatment of depression. Olanzapine An antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders. Opiranserin Opiranserin is under investigation in clinical trial NCT03997838 (Evaluate the Efficacy and Safety of VVZ-149 Injections for the Treatment of Post-operative Pain Following Abdominoplasty). Paliperidone An atypical antipsychotic used in the treatment of schizophrenia and other schizoaffective or delusional disorders. Pimozide An antipsychotic used to manage debilitating motor and phonic tics in patients with Tourette's Disorder. Pipotiazine An antipsychotic indicated for the management of chronic, non-agitated schizophrenic patients. Pizotifen A serotonin and tryptamine antagonist indicated for migraine prophylaxis. Promazine A phenothiazine used to manage schizophrenia. Propiomazine Propiomazine is largely used for its antihistamininc sleep inducing effects in treating insomnia. Quetiapine An atypical antipsychotic agent used for the management of bipolar disorder, schizophrenia, and major depressive disorder. Risperidone A second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression. Roluperidone Roluperidone has been used in trials studying the treatment of Schizophrenia. SB-773812 SB-773812 is under investigation in clinical trial NCT00259870 (SB-773812 Administered in Adults With Schizophrenia). Seganserin Seganserin is a small molecule drug. The usage of the INN stem '-anserin' in the name indicates that Seganserin is a serotonin receptor antagonist. Seganserin has a monoisotopic molecular weight... Sertindole An atypical antipsychotic indicated in the treatment of schizophrenia. Spiramide Spiramide is a small molecule drug. Spiramide has a monoisotopic molecular weight of 383.2 Da. Tedatioxetine Tedatioxetine has been used in trials studying the treatment of Major Depressive Disorder. Tegaserod A serotonin-4 (5-HT4) receptor agonist indicated for the treatment of constipation predominant irritable bowel syndrome (IBS-C) specifically in women under the age of 65. There is currently no safety or efficacy data for use of tegaserol in men. Terguride Not Annotated Thioridazine A phenothiazine antipsychotic used to treat schizophrenia and generalized anxiety disorder. Thiothixene An antipsychotic indicated for the management of schizophrenia. Trazodone A serotonin uptake inhibitor used to treat major depressive disorder. Trifluoperazine A phenothiazine used to treat depression, anxiety, and agitation. Vabicaserin Vabicaserin has been used in trials studying the health services research and treatment of Schizophrenia. Volinanserin Volinanserin is under investigation in clinical trial NCT00464243 (Efficacy and Safety of Volinanserin on Sleep Maintenance Insomnia - Polysomnographic Study). Yohimbine An alpha-2-adrenergic blocker and sympatholytic found in supplements used to. Ziprasidone An atypical antipsychotic used to manage schizophrenia, bipolar mania, and agitation in patients with schizophrenia. Zotepine Zotepine, like other atypical antipsychotics, is considered as the first-line treatment in newly diagnosed schizophrenia. It is usually thought to be an option of choice for managing acute schizophrenic episodes... Zuclopenthixol An antipsychotic indicated for the management of schizophrenia. The acuphase formulation is indicated for initial treatment of acute psychosis or exacerbation of psychosis, while the depot formulation is best for maintenance. - Drugs & Drug Targets