Oesophageal varices haemorrhage (DBCOND0011344)

Identifiers

Synonyms

Esophageal Varices Bleeding / Bleeding Esophageal Varices / Esophageal varices with bleeding / Esophageal varices / Oesophageal varices ruptured / Esophageal varices ruptured / Oesophageal varices with bleeding / Bleeding oesophageal varices / Esophageal varices hemorrhage / Bleeding esophageal varices (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Somatostatin	A natural peptide hormone used to treat acute bleeding from esophageal varices, gastrointestinal ulcers, and gastritis; prevent pancreatic complications after surgery; and restrict secretions of the upper intestine, pancreas, and biliary tract.	Somatostatin receptor type 1target Somatostatin receptor type 2target Somatostatin receptor type 3target Somatostatin receptor type 4target Somatostatin receptor type 5target ATP-dependent translocase ABCB1transporter Cytochrome P450 3A4enzyme Mu-type opioid receptortarget Delta-type opioid receptortarget
Terlipressin	A drug used to treat bleeding caused by esophageal varices.	Vasopressin V1a receptortarget Vasopressin V2 receptortarget Vasopressin V1b receptortarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT03683121	The Compliance and Prognosis of NSBB Secondary Prevention of Cirrhosis With Gastroesophageal Varices Bleeding	No drug interventions	Not Available	Not Available	unknown_status
NCT05302661	Effect of Re-education on Rebleeding Rate After Endoscopic Treatment in Liver Cirrhosis	No drug interventions	treatment	Not Available	unknown_status
NCT02475122	Prognostic Value of Measuring DsAz by MRI in Cirrhotic Patients on Prophylactic Treatment With β Blocker (AzyMR)	No drug interventions	other	Not Available	completed
NCT01970748	Primary Prevention of Patients With Hepatocellular Carcinoma and Concomitant Esophageal Varices	Propranolol	treatment	4	recruiting
NCT02853526	TIPS for Variceal Rebleeding in Cirrhotic Patients With Occlusive Portal Vein Thrombosis and CTPV	Propranolol Warfarin	treatment	3	unknown_status
NCT01095185	Efficacy of Statin Association With Standard Treatment in Prevention of Recurrent Hemorrhage in Patient With Cirrhosis and Variceal Bleeding	Simvastatin	treatment	3	completed
NCT03624517	Comparison of 24-hours Versus 72-hours of Octreotide Infusion in Preventing Early Rebleed From Esophageal Varices	Octreotide	treatment	4	recruiting
NCT03388125	Endoscopic Injection Sclerotherapy Versus N-butyl-2-cyanoacrylate Injection	Enbucrilate Ethanolamine oleate	treatment	3	unknown_status