bacterial skin infections (DBCOND0020327)

Identifiers

Synonyms

Skin infection bacterial / Skin Diseases, Bacterial / Skin Infections, Bacterial / Skin bacterial infection / Bacterial Skin Disease / Bacterial skin infection / Bacterial Skin Diseases / Skin Disease, Bacterial / Bacterial dermatoses / Bacterial infection of skin (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Ampicillin	A penicillin derivative used for the treatment of a variety of infections caused by gram-positive and gram-negative bacteria as well as some anaerobes.	Albumincarrier Organic cation/carnitine transporter 2transporter Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Penicillin-binding protein 2atarget Penicillin-binding protein 1btarget Penicillin-binding protein 3target Penicillin-binding protein 1Atarget Penicillin-binding protein 2Btarget Monocarboxylate transporter 1transporter Solute carrier family 15 member 1target Solute carrier family 15 member 2target Angiopoietin-1 receptortarget
Betamethasone	A systemic corticosteroid used to relieve inflammation in various conditions, including but not limited to allergic states, dermatologic disorders, gastrointestinal diseases, and hematological disorders.	Glucocorticoid receptortarget Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Aromataseenzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Cytochrome P450 2A6enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Albumincarrier Corticosteroid-binding globulincarrier
Cetrimonium	A compound that can be used as a topical antiseptic.	Cyclopropane mycolic acid synthase MmaA2target Cyclopropane mycolic acid synthase 1target
Chlorhexidine	An antiseptic used to sterilize for surgeries and in healthcare practice, to reduce pocket depth in periodontitis, and to treat gingivitis.	Bacterial outer membranetarget Albumincarrier
Chloroxine	An antibacterial agent used for the treatment of dandruff and mild to moderately severe seborrheic dermatitis of the scalp.	Kappa-type opioid receptortarget
Chlortetracycline	The first tetracycline antibiotic most commonly used for veterinary purposes.	16S ribosomal RNAtarget Albumincarrier 30S ribosomal protein S3target 30S ribosomal protein S8target 30S ribosomal protein S19target 30S ribosomal protein S14target 30S ribosomal protein S7target ADP-ribosylation factor 1target Catalasetarget Ephrin type-B receptor 1target Pancreatic triacylglycerol lipasetarget Protein-arginine deiminase type-4target
Clioquinol	An antifungal cream used to treat a variety of fungal infections.	Kappa-type opioid receptortarget
Diphenylpyraline	An antihistamine used for the treatment of allergic rhinitis, hay fever, and allergic skin disorders.	Histamine H1 receptortarget Sodium-dependent dopamine transportertarget
Ethanol	For therapeutic neurolysis of nerves or ganglia for the relief of intractable chronic pain in such conditions as inoperable cancer and trigeminal neuralgia (tic douloureux), in patients for whom neurosurgical...	Gamma-aminobutyric acid receptor subunit alpha-1target Glutamate receptor ionotropic, NMDA 3Atarget Glycine receptor subunit alpha-1target Glycine receptor subunit alpha-2target Cytochrome P450 2E1enzyme Cytochrome P450 1A1enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A4enzyme Cytochrome P450 4A11enzyme Alcohol dehydrogenase 1Aenzyme All-trans-retinol dehydrogenase [NAD(+)] ADH1Benzyme Alcohol dehydrogenase 1Cenzyme Alcohol dehydrogenase class-3enzyme Voltage-dependent L-type calcium channel subunit beta-1target 5-hydroxytryptamine receptor 3Atarget All-trans-retinol dehydrogenase [NAD(+)] ADH4enzyme Gamma-aminobutyric acid receptor subunit alpha-2target Neuronal acetylcholine receptor subunit alpha-10target Voltage-dependent L-type calcium channel subunit alpha-1Ctarget Gamma-aminobutyric acid receptor subunit alpha-5target Gamma-aminobutyric acid receptor subunit alpha-4target All-trans-retinol dehydrogenase [NAD(+)] ADH7enzyme Gamma-aminobutyric acid receptor subunit alpha-3target Glutamate receptor 1target Voltage-dependent calcium channel gamma-1 subunittarget Neuronal acetylcholine receptor subunit alpha-2target Gamma-aminobutyric acid receptor subunit alpha-6target Glutamate receptor 2target Glutamate receptor 4target Glutamate receptor 3target Neuronal acetylcholine receptor subunit alpha-4target Neuronal acetylcholine receptor subunit beta-2target G protein-activated inward rectifier potassium channel 1target G protein-activated inward rectifier potassium channel 2target Vascular cell adhesion protein 1target Equilibrative nucleoside transporter 1target G protein-activated inward rectifier potassium channel 4target Neuronal acetylcholine receptor subunit alpha-7target Neuronal acetylcholine receptor subunit alpha-9target Gamma-aminobutyric acid receptor subunit beta-1target Gamma-aminobutyric acid receptor subunit beta-3target Gamma-aminobutyric acid receptor subunit beta-2target Voltage-dependent L-type calcium channel subunit alpha-1Starget Voltage-dependent L-type calcium channel subunit alpha-1Dtarget Alcohol dehydrogenase 6enzyme Neuronal acetylcholine receptor subunit beta-4target Neuronal acetylcholine receptor subunit alpha-3target Neuronal acetylcholine receptor subunit alpha-5target Neuronal acetylcholine receptor subunit alpha-6target Neuronal acetylcholine receptor subunit beta-3target Gamma-aminobutyric acid receptor subunit gamma-1target Gamma-aminobutyric acid receptor subunit gamma-3target Gamma-aminobutyric acid receptor subunit epsilontarget Gamma-aminobutyric acid receptor subunit pitarget Gamma-aminobutyric acid receptor subunit thetatarget Gamma-aminobutyric acid receptor subunit deltatarget Aldo-keto reductase family 1 member A1enzyme Equilibrative nucleoside transporter 2target 5-hydroxytryptamine receptor 3Etarget 5-hydroxytryptamine receptor 3Btarget 5-hydroxytryptamine receptor 3Dtarget 5-hydroxytryptamine receptor 3Ctarget Voltage-dependent calcium channel gamma-2 subunittarget G protein-activated inward rectifier potassium channel 3target Neural cell adhesion molecule L1target Acetylcholinesterasetarget All-trans-retinol dehydrogenase [NAD(+)] ADH7target
Fluocinolone acetonide	A corticosteroid used to treat skin conditions, eczematous otitis externa, diabetic macular edema, and non-infectious uveitis of the posterior segment of the eye.	Corticosteroid-binding globulincarrier Glucocorticoid receptortarget Cytochrome P450 3A4enzyme Annexin A1target Annexin A2target Annexin A3target Annexin A4target Annexin A5target Phospholipase A2target
Fluprednidene acetate	A corticosteroid indicated in the treatment of corticosteroid-responsive dermatoses.	Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme
Framycetin	An aminoglycoside antibiotic used in various formulations and combinations with other agents to treat hemorrhoids, eye and ear infections, and to reduce nasal carriage of staphylococcus.	30S ribosomal protein S12target 16S ribosomal RNAtarget C-X-C chemokine receptor type 4target
Fusidic acid	A topical antibacterial agent used to prevent and treat mild to moderate skin infections caused by susceptible bacteria.	Chloramphenicol acetyltransferase 3target Chloramphenicol acetyltransferasetarget Bile salt export pumptransporter ATP-binding cassette sub-family C member 2transporter Elongation factor Gtarget Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme UDP-glucuronosyltransferase 1A1enzyme Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter
Gentamicin	An aminoglycoside used to treat a wide variety of aerobic infections in the body.	30S ribosomal protein S12target 16S ribosomal RNAtarget NH(3)-dependent NAD(+) synthetasetarget Dihydrofolate reductasetarget 23S ribosomal RNAtarget Bacterial outer membranetarget Cytoplasmic membranetarget Low-density lipoprotein receptor-related protein 2transporter Solute carrier family 22 member 2transporter ATP-binding cassette sub-family C member 2transporter
Neomycin	An aminoglycoside antibiotic agent used orally and topically to treat a wide variety of infections in the body.	30S ribosomal protein S12target 16S ribosomal RNAtarget Extracellular calcium-sensing receptortarget
Prednisolone	A glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers.	Corticosteroid-binding globulincarrier Cytochrome P450 3A4enzyme Glucocorticoid receptortarget Solute carrier organic anion transporter family member 1A2transporter ATP-dependent translocase ABCB1transporter Albumincarrier
Salicylic acid	An acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts.	Albumincarrier Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Aldo-keto reductase family 1 member C1target Solute carrier family 22 member 6transporter Solute carrier family 22 member 10transporter Organic anion transporter 3transporter Solute carrier family 22 member 11transporter Solute carrier organic anion transporter family member 2B1transporter Monocarboxylate transporter 1transporter Solute carrier family 22 member 7transporter Cytochrome P450 2C9enzyme Carbonic anhydrase 6target Carbonic anhydrase 12target Carbonic anhydrase 2target Carbonic anhydrase 4target Carbonic anhydrase 1target
Sulfametrole	An antibiotic indicated in combination intravenous products for various bacterial infections.	No drug targets
Tetraethylammonium	Tetraethylammonium is an experimental drug with no approved indication.	Solute carrier family 22 member 1transporter Solute carrier family 22 member 2transporter Solute carrier family 22 member 3transporter Solute carrier family 22 member 4transporter Organic cation/carnitine transporter 2transporter Organic anion transporter 3transporter pH-gated potassium channel KcsAtarget Neuronal acetylcholine receptor subunit alpha-9target Calcium-activated potassium channel subunit alpha-1target Potassium voltage-gated channel subfamily A member 1target Multidrug and toxin extrusion protein 1transporter Aquaporin-1target Small conductance calcium-activated potassium channel protein 2target Small conductance calcium-activated potassium channel protein 3target Potassium voltage-gated channel subfamily A member 3target Small conductance calcium-activated potassium channel protein 1target Potassium voltage-gated channel subfamily KQT member 3target Calcium-activated potassium channel subunit beta-4target Potassium voltage-gated channel subfamily A member 5target Multidrug and toxin extrusion protein 1target Potassium channel subfamily T member 1target Potassium channel subfamily T member 2target
Tioconazole	An imidazole antifungal used to treat vulvovaginal candidiasis.	Lanosterol 14-alpha demethylasetarget Aromataseenzyme Cytochrome P450 2C19enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A4enzyme Lanosterol 14-alpha demethylasetarget
Triclosan	An antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew.	Enoyl-[acyl-carrier-protein] reductase [NADH] FabItarget Enoyl-[acyl-carrier-protein] reductase [NADH]target Enoyl-[acyl-carrier-protein] reductase [NADH] FabItarget Enoyl-[acyl-carrier-protein] reductase [NADH]target Enoyl-[acyl-carrier-protein] reductase [NADPH] FabItarget Nuclear receptor subfamily 1 group I member 2target Androgen receptortarget Nuclear receptor subfamily 1 group I member 3target Peroxisome proliferator-activated receptor gammatarget Thyroid peroxidasetarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01369251	Simple Hygiene Versus Alcohol Based Usual Care for Umbilical Cord	No drug interventions	prevention	3	unknown_status
NCT02979951	Fosfomycin i.v. for Treatment of Severely Infected Patients	No drug interventions	Not Available	Not Available	recruiting
NCT00488345	Study Evaluating the Pharmacokinetics (PK), Safety, and Tolerability of Tigecycline in Patients 8 to 11 Years of Age	Tigecycline	treatment	2	completed
NCT00249197	A Study of the Safety and Effectiveness of Levofloxacin Compared to Ticarcillin/Clavulanate Alone or Followed by Amoxicillin/Clavulanate in the Treatment of Complicated Skin Infections	Levofloxacin	treatment	3	completed
NCT00997997	Avelox in Complicated Skin and Skin Structure Infections	Moxifloxacin	Not Available	Not Available	completed
NCT03747497	Contezolid Acefosamil Versus Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infection	Linezolid	treatment	2	completed
NCT00761215	Phase 2 Study of TR-701 in Patients With Complicated Skin and Skin Structure Infections	Tedizolid phosphate	treatment	2	completed
NCT00368537	Study Comparing the Safety and Efficacy of Tigecycline With Ampicillin-Sulbactam or Amoxicillin-Clavulanate to Treat Skin Infections	Ampicillin Sulbactam Tigecycline	treatment	4	completed
NCT00948142	Safety and Efficacy of CEM-102 Compared to Linezolid in Acute Bacterial Skin Infections	Fusidic acid Linezolid	treatment	2	completed
NCT00210899	Ceftobiprole in the Treatment of Resistant Staphylococcus Aureus Skin and Skin Structure Infections	Ceftazidime Ceftobiprole medocaril Vancomycin	treatment	3	completed
NCT02276482	Study of Tedizolid Phosphate in Adolescents With Complicated Skin and Soft Tissue Infection (cSSTI) (MK-1986-012)	Aztreonam Cefazolin Cephalexin Clindamycin Flucloxacillin Linezolid Metronidazole Tedizolid Tedizolid phosphate Vancomycin	treatment	3	completed
NCT02477514	A Study to Evaluate the Effects of Tedizolid Phosphate on the Pharmacokinetics and Safety of Midazolam and Rosuvastatin (MK-1986-004)	Midazolam Rosuvastatin Tedizolid phosphate	treatment	1	completed
NCT02925416	Safety of Either a Single or Two Intravenous Doses of Orbactiv in Participants With Acute Bacterial Skin and Skin Structure Infection	Oritavancin	other	4	completed
NCT00228982	Ceftobiprole in the Treatment of Resistant Staphylococcus Aureus Skin and Skin Structure Infections	Ceftobiprole medocaril Vancomycin	treatment	3	completed
NCT04485676	Dalbavancin in Real Clinical Practice in Spain	No drug interventions	Not Available	Not Available	completed
NCT01619410	Asymptomatic Colonization With S. Aureus After Therapy With Linezolid or Clindamycin for Acute Skin Infections	Clindamycin Linezolid	treatment	Not Available	terminated
NCT00303550	Study of Intravenous (I.V.) Iclaprim Versus Linezolid in Complicated Skin and Skin Structure Infections [cSSSI] (ASSIST-2)	Iclaprim Linezolid	treatment	3	completed
NCT01209078	GSK1322322 Versus Linezolid in the Treatment of Acute Bacterial Skin and Skin Structure Infection	Lanopepden Linezolid	treatment	2	completed
NCT01445600	ALTARGO(Retapamulin) PMS(Post-marketing Surveillance)	Retapamulin	Not Available	Not Available	completed
NCT00852540	Retapamulin Versus Linezolid in the Treatment of SITL and Impetigo Due to MRSA	Linezolid Retapamulin	treatment	3	completed
NCT00684177	Retapamulin Versus Placebo in Secondarily-Infected Traumatic Lesions (SITL)	Retapamulin	treatment	3	completed
NCT00555061	Pharmacokinetics of Retapamulin in Pediatric Subjects With Uncomplicated Skin Infections.	Retapamulin	treatment	4	completed
NCT00133874	Topical SB-275833 Ointment, 1% For The Treatment Of Impetigo	Retapamulin	treatment	3	completed
NCT01812382	Retapamulin Microdialysis Feasibility Study	Retapamulin	treatment	1	completed
NCT01153880	United States Pharmacovigilence Retapamulin-Prescribing	Mupirocin Retapamulin	Not Available	Not Available	completed
NCT03716024	Study the Efficacy and Safety of PTK 0796 in Patients With Complicated Skin and Skin Structure Infection (CSSSI)	Linezolid Omadacycline	treatment	2	completed
NCT01700842	Multicenter Study of Antimicrobial Resistance of Gram-positive and Gram-negative Clinical Strains to Ceftaroline and Other Antimicrobials in Russia	No drug interventions	Not Available	Not Available	completed
NCT00646958	Safety and Efficacy Study of Oxazolidinones to Treat Uncomplicated Skin Infections	Linezolid Radezolid	treatment	2	completed
NCT00719810	Safety and Efficacy Study of a Fluoroquinolone to Treat Complicated Skin Infections	Delafloxacin Tigecycline	treatment	2	completed
NCT02024867	Evaluation of 3 Versus 10 Days of Antibiotics in Skin Abscesses After Surgical Drainage	Sulfamethoxazole Trimethoprim	treatment	Not Available	completed