moderate Pain (DBCOND0020636)

Identifiers

Synonyms

Moderate pain / Moderate pain (finding)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Acetaminophen	An analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Cytochrome P450 1A2enzyme Cytochrome P450 2E1enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2D6enzyme Cytochrome P450 2A6enzyme Cytochrome P450 3A4enzyme UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1-6enzyme UDP-glucuronosyltransferase 1A9enzyme UDP-glucuronosyltransferase 2B15enzyme Sulfotransferase 1A1enzyme Sulfotransferase 1A3enzyme Arylamine N-acetyltransferase 2enzyme Prostaglandin E synthase 3target Transient receptor potential cation channel subfamily V member 1target Albumincarrier Fatty-acid amide hydrolase 1enzyme Glutathione S-transferase Penzyme Glutathione S-transferase Mu 1enzyme Sodium-dependent noradrenaline transportertarget Sodium-dependent serotonin transportertarget
Acetylsalicylic acid	A salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Aldo-keto reductase family 1 member C1target Solute carrier family 22 member 6transporter ATP-dependent translocase ABCB1transporter Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme 5'-AMP-activated protein kinasetarget Endothelin-1 receptortarget Cellular tumor antigen p53target Endoplasmic reticulum chaperone BiPtarget Ribosomal protein S6 kinase alpha-3target NF-kappa-B inhibitor alphatarget Tumor necrosis factor-inducible gene 6 proteintarget Caspase-1target Caspase-3target Inhibitor of nuclear factor kappa-B kinase subunit betatarget Extracellular signal-regulated kinase (ERK)target G1/S-specific cyclin-D1target Myc proto-oncogene proteintarget Proliferating cell nuclear antigentarget Cyclin Atarget UDP-glucuronosyltransferase 1-6enzyme Arylamine N-acetyltransferase 2enzyme Organic anion transporter 3transporter Sialidase-1target 3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
Buprenorphine	A partial opioid agonist used for management of severe pain that is not responsive to alternative treatments. Also used for maintenance treatment of opioid addiction.	Kappa-type opioid receptortarget Mu-type opioid receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 2D6enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 2C9enzyme Cytochrome P450 3A5enzyme Cytochrome P450 2C8enzyme Cytochrome P450 3A7enzyme Delta-type opioid receptortarget Cytochrome P450 2C18enzyme Cytochrome P450 2C19enzyme Nociceptin receptortarget
Caffeine	A stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth.	Adenosine receptor A1target 3',5'-cyclic-AMP phosphodiesterase 4Btarget Adenosine receptor A2atarget Cytochrome P450 1A2enzyme Ryanodine receptor 1target Cytochrome P450 3A4enzyme Cytochrome P450 2E1enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 1A1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2D6enzyme Cyclic nucleotide phosphodiesterasetarget DNA-dependent protein kinase catalytic subunittarget Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformtarget Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformtarget Inositol 1,4,5-trisphosphate receptortarget Serine-protein kinase ATMtarget Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Adenosine receptor A2btarget Adenosine receptor A3target Phosphodiesterase enzymestarget 5'-nucleotidasetarget
Cannabidiol	An active cannabinoid used as an adjunctive treatment for the management of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome and symptomatic relief of moderate to severe neuropathic pain or other painful conditions, like cancer.	Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme Cannabinoid receptor 1target Cannabinoid receptor 2target G-protein coupled receptor 12target Glycine receptor subunit alpha-1target Glycine receptor (alpha-1/beta)target Glycine receptor subunit alpha-3target N-arachidonyl glycine receptortarget G-protein coupled receptor 55target 5-hydroxytryptamine receptor 1Atarget 5-hydroxytryptamine receptor 2Atarget Neuronal acetylcholine receptor subunit alpha-7target Delta-type opioid receptortarget Mu-type opioid receptortarget Peroxisome proliferator-activated receptor gammatarget Cytochrome P450 3A5enzyme Serotonin N-acetyltransferaseenzyme Cytochrome P450 1A1enzyme Fatty-acid amide hydrolase 1enzyme Polyunsaturated fatty acid 5-lipoxygenaseenzyme Polyunsaturated fatty acid lipoxygenase ALOX15enzyme Quinone oxidoreductaseenzyme Multidrug resistance-associated protein 1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Equilibrative nucleoside transporter 1transporter Transient receptor potential cation channel subfamily V member 1target Voltage-dependent T-type calcium channel subunit alpha-1Gtarget Voltage-dependent T-type calcium channel subunit alpha-1Htarget Voltage-dependent T-type calcium channel subunit alpha-1Itarget Transient receptor potential cation channel subfamily A member 1target Transient receptor potential cation channel subfamily M member 8target Transient receptor potential cation channel subfamily V member 2target Transient receptor potential cation channel subfamily V member 3target Transient receptor potential cation channel subfamily V member 4target Non-selective voltage-gated ion channel VDAC1target 5-hydroxytryptamine receptor 3Atarget Adenosine receptor A1target Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Acetyl-CoA acetyltransferase, mitochondrialtarget Steroid 17-alpha-hydroxylase/17,20 lyasetarget 3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget Glutathione reductase, mitochondrialtarget Glutathione peroxidase 1target Indoleamine 2,3-dioxygenase 1target Cytochrome P450 1B1target NAD(P)H dehydrogenase [quinone] 1target Catalasetarget Cytochrome P450 3A5target Cytochrome P450 2D6target Superoxide dismutase [Cu-Zn]target Cytochrome P450 1A2target Cytochrome P450 3A7target Serotonin N-acetyltransferasetarget N-acylethanolamine-hydrolyzing acid amidasetarget Cytochrome P450 1A2enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A7enzyme UDP-glucuronosyltransferase 1A7enzyme UDP-glucuronosyltransferase 1A9enzyme UDP-glucuronosyltransferase 2B7enzyme UDP-glucuronosyltransferase 2B17enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2J2enzyme Liver carboxylesterase 1enzyme
Choline magnesium trisalicylate	Choline magnesium trisalicylate is used to reduce pain and inflammation caused by conditions such as arthritis. This medication is also used to treat fever in adults.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target
Codeine	An opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated.	Mu-type opioid receptortarget Delta-type opioid receptortarget Kappa-type opioid receptortarget Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme Solute carrier family 22 member 1transporter UDP-glucuronosyltransferase 2B7enzyme UDP-glucuronosyltransferase 2B4enzyme
Diflunisal	An NSAID used to treat mild to moderate pain, inflammation, osteoarthritis, and rheumatoid arthritis.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Transthyretincarrier Albumincarrier Solute carrier family 22 member 6transporter UDP-glucuronosyltransferase 1A8enzyme UDP-glucuronosyltransferase 1A9enzyme
Dihydrocodeine	An opioid analgesic agent used for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.	Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme
Etoricoxib	A selective COX-2 inhibitor used to relieve moderate post-surgical dental pain as a short-term treatment and inflammatory and painful symptoms of various forms of arthritis.	Prostaglandin G/H synthase 2target Cytochrome P450 3A4enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2D6enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2E1enzyme
Fenoprofen	An anti-inflammatory analgesic used to treat mild to moderate pain in addition to the signs and symptoms of rheumatoid arthritis and osteoarthritis.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Albumincarrier Peroxisome proliferator-activated receptor alphatarget Peroxisome proliferator-activated receptor gammatarget
Hydrocodone	An opioid agonist used as an analgesic and antitussive agent.	Mu-type opioid receptortarget Delta-type opioid receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 2D6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Sigma non-opioid intracellular receptor 1target
Ibuprofen	An NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Cytochrome P450 2C9enzyme Albumincarrier ATP-binding cassette sub-family C member 4transporter Multidrug resistance-associated protein 1transporter Solute carrier organic anion transporter family member 1A2transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Solute carrier family 22 member 11transporter Solute carrier organic anion transporter family member 2B1transporter ATP-dependent translocase ABCB1transporter UDP-glucuronosyltransferase 1A3enzyme UDP-glucuronosyltransferase 1A9enzyme UDP-glucuronosyltransferase 2B4enzyme UDP-glucuronosyltransferase 2B7enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C19enzyme Apoptosis regulator Bcl-2target Thrombomodulintarget Fatty acid-binding protein, intestinaltarget Peroxisome proliferator-activated receptor gammatarget Cystic fibrosis transmembrane conductance regulatortarget Peroxisome proliferator-activated receptor alphatarget Platelet glycoprotein Ib alpha chaintarget Protein S100-A7target Alpha-methylacyl-CoA racemaseenzyme Cytochrome P450 3A4enzyme C-X-C chemokine receptor type 1target C-X-C chemokine receptor type 2target Interleukin-8target
Ketoprofen	An NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, dysmenorrhea, mild to moderate muscle pain, postoperative pain, and postpartum pain.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target C-X-C chemokine receptor type 1target Albumincarrier ATP-binding cassette sub-family C member 4transporter Solute carrier organic anion transporter family member 1A2transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Solute carrier family 22 member 11transporter Solute carrier family 22 member 7transporter Cytochrome P450 2C9enzyme Cytochrome P450 2C8enzyme UDP-glucuronosyltransferase 1A1enzyme
Levorphanol	An opioid analgesic used to treat moderate to severe pain.	Mu-type opioid receptortarget Delta-type opioid receptortarget Kappa-type opioid receptortarget
Meclofenamic acid	An NSAID used to treat mild to moderate pain, primary dysmenorrhea, heavy menstrual blood loss, rheumatoid arthritis, and osteoarthritis.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Polyunsaturated fatty acid 5-lipoxygenasetarget Solute carrier family 22 member 6transporter Solute carrier organic anion transporter family member 1C1transporter Potassium voltage-gated channel subfamily KQT member 2target Potassium voltage-gated channel subfamily KQT member 3target Thyroxine-binding globulincarrier
Mefenamic acid	An NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea.	Prostaglandin G/H synthase 2target Prostaglandin G/H synthase 1target Cytochrome P450 2C9enzyme Cytochrome P450 2C8enzyme Albumincarrier UDP-glucuronosyltransferase 1A9enzyme Cytochrome P450 1A2enzyme UDP-glucuronosyltransferase 2B7enzyme
Methoxyflurane	For use in the induction and maintenance of general anesthesia	Calcium-transporting ATPase type 2C member 1target NADH-ubiquinone oxidoreductase chain 1target Gamma-aminobutyric acid receptor subunit alpha-1target Potassium voltage-gated channel subfamily A member 1target Glutamate receptor 1target Glycine receptor subunit alpha-1target Cytochrome P450 2E1enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme GABA(A) Receptortarget
Nalbuphine	An opioid agonist-antagonist used to treat pain, for pre and postoperative analgesia, and for analgesia in labor and delivery.	Kappa-type opioid receptortarget Mu-type opioid receptortarget Delta-type opioid receptortarget
Naloxone	An opioid receptor antagonist used to rapidly reverse an opioid overdose. Also included in some drug formulations as an abuse deterrent to prevent injection.	Mu-type opioid receptortarget Estrogen receptortarget Cyclic AMP-responsive element-binding protein 1target Delta-type opioid receptortarget Solute carrier organic anion transporter family member 1A2transporter ATP-dependent translocase ABCB1transporter Kappa-type opioid receptortarget Cytochrome P450 3A4enzyme Albumincarrier Toll-like receptor 4target Liver carboxylesterase 1target UDP-glucuronosyltransferase 1A1enzyme Cytochrome P450 2C18enzyme Cytochrome P450 2C19enzyme
Orphenadrine	A muscarinic antagonist used as an adjunct for the symptomatic relief of musculoskeletal pain and discomfort.	Glutamate receptor ionotropic, NMDA 1target Glutamate receptor ionotropic, NMDA 2Dtarget Glutamate receptor ionotropic, NMDA 3Btarget Glutamate receptor ionotropic, NMDA 3Atarget Histamine H1 receptortarget Cytochrome P450 2B6enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A4enzyme Sodium-dependent noradrenaline transportertarget Sodium channel protein type 10 subunit alphatarget Cytochrome P450 1A2enzyme Cytochrome P450 2D6enzyme Albumincarrier
Oxymorphone	An opioid analgesic used in the management of moderate-to-severe pain and for analgesic therapies.	Mu-type opioid receptortarget Cytochrome P450 2D6enzyme Delta-type opioid receptortarget Cytochrome P450 3A4enzyme
Pentazocine	An analgesic used to treat moderate to severe pain.	Mu-type opioid receptortarget Kappa-type opioid receptortarget Sigma non-opioid intracellular receptor 1target ATP-dependent translocase ABCB1transporter
Tramadol	A centrally-acting opioid agonist and SNRI (serotonin/norepinephrine reuptake inhibitor) used for the management of moderate to severe pain in adults.	Mu-type opioid receptortarget Sodium-dependent noradrenaline transportertarget 5-hydroxytryptamine receptor 2Ctarget Kappa-type opioid receptortarget Sodium-dependent serotonin transportertarget Cytochrome P450 2D6enzyme Delta-type opioid receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 2B6enzyme Neuronal acetylcholine receptor subunit alpha-7target Muscarinic acetylcholine receptor M3target Muscarinic acetylcholine receptor M1target UDP-glucuronosyltransferase 1A1enzyme Substance-P receptortarget Sodium channel protein type 2 subunit alphatarget Transient receptor potential cation channel subfamily V member 1target NMDA receptortarget Adenosine receptor A1target Alpha-2 adrenergic receptorstarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT03225352	A Study to Assess Disintegration of the New Aspirin Disintegrating Tablets	Acetylsalicylic acid Ibuprofen	other	1	completed
NCT06237231	Efficacy and Safety of DIT112 in the Treatment of Moderate to Severe Pain After Dental Surgery for the Extraction of Impacted Third Molars	Metamizole Tramadol	treatment	3	not_yet_recruiting