Clostridium Difficile (DBCOND0035674)

Identifiers

Synonyms
Clostridium difficile / Clostridioides difficile (organism) / Clostridioides difficile

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Teicoplanin
A glycopeptide antibiotic with a similar mechanism of action and spectrum of activity to vancomycin used to treat various infections caused by gram-positive bacteria.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT06237452
VE303 for Prevention of Recurrent Clostridioides Difficile Infectionprevention3recruiting
NCT02589964
Probiotics in the Reduction of Antibiotic Associated DiarrheaNo drug interventionsprevention1terminated
NCT01066221
Comparative Study of Three Different Testing Mechanisms for Clostridium DifficileNo drug interventionsNot AvailableNot Availablecompleted
NCT03760484
Fecal Microbiota Transplant (FMT) Plus Fidaxomicin for Severe or Fulminant Clostridium Difficile Infectiontreatment2terminated
NCT02437487
SER-109 Versus Placebo to Prevent Recurrent Clostridium Difficile Infection (RCDI)No drug interventionsprevention2completed
NCT02375477
Improved Adherence to C. Difficile Isolation Protocols Through Improved Education MethodsNo drug interventionshealth_services_researchNot Availablecompleted
NCT02466698
Intestinal Lavage for the Treatment of Severe C. Difficile Infectionstreatment2 / 3unknown_status
NCT03368105
Prevention of Clostridium Difficile Infections Using Lactobacillus Plantarum 299v StrainNo drug interventionspreventionNot Availableunknown_status
NCT02343328
Placebo Controlled Study of Fecal Microbiota Transplant (FMT) for a First or Second Episode of C. Difficile Infection in Adults Using a Frozen Encapsulated Inoculumtreatment1terminated
NCT02394275
A Prospective Trial of Frozen-and-Thawed Fecal Microbiota Transplantation for Recurrent Clostridium Difficile Infectiontreatment2terminated
NCT02316470
Dose-Confirmation, Immunogenicity and Safety Study of the Clostridium Difficile Vaccine Candidate VLA84 in Healthy Adults Aged 50 Years and Older. Phase II StudyNo drug interventionsprevention2completed
NCT03937999
Bezlotoxumab as Secondary Prophylaxis for C. Difficile in High-risk Hospitalized Patients Exposed to Antibiotics.prevention4terminated
NCT03778606
Oligosaccharide for Cdiff(+) Heme-onc PatientsNo drug interventionspreventionNot Availablecompleted
NCT02179658
A Study to Compare Safety and Efficacy of OPT-80(Fidaxomicin) With Vancomycin in Subjects With Clostridium Difficile-associated Diarrhea (CDAD)treatment3completed
NCT02465463
Early FMT for C.DifficileNo drug interventionstreatment1 / 2completed
NCT00591357
Efficacy of Loperamide for C. Difficile Colitis and Other Diarrheal Diseases Associated With Antibiotic Therapytreatment4suspended
NCT02052726
A Study To Investigate A Clostridium Difficile Vaccine In Healthy Adults Aged 50 To 85 Years, Who Will Each Receive 3 Doses Of Vaccine.No drug interventionsprevention1completed
NCT01680874
Probiotics for Clostridium Difficile Infection in Older AdultsNo drug interventionstreatment2completed
NCT03117582
Fecal Microbiota Transplantation (FMT) in Clostridium Difficile Infection (CDI) Not Responding to AntibioticsNo drug interventionsNot AvailableNot Availablecompleted
NCT03606031
Digestive Microbiota TransplantNo drug interventionsNot AvailableNot Availableunknown_status
NCT03848689
FQ Restriction for the Prevention of CDINo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT01087892
Probiotics in Preventing Antibiotic Associated Diarrhoea Including Clostridium Difficile InfectionNo drug interventionspreventionNot Availablecompleted
NCT01533844
To Determine the Feasibility of a Fidaxomicin Study in Neonates and to Assess C. Difficile (Clostridium Difficile) Involvement in the PathogenesisNo drug interventionsNot AvailableNot Availableterminated
NCT02896244
AssessmeNT of the Incidence of Clostridium Difficile Infections in Hospitalized Patients on Antibiotic TrEatmentNo drug interventionsNot AvailableNot Availablecompleted
NCT02207140
Effect of Multi-species Probiotic HOWARU® Restore, on Gut Microbiota of ElderlyNo drug interventionsbasic_science0completed
NCT02254967
A Phase IIIB/IV Study to Compare the Efficacy of Vancomycin Therapy to Extended Duration of Fidaxomicin Therapy in the Clinical Cure of Clostridium Difficile Infection (CDI) in an Older Populationtreatment4completed
NCT02148601
Fecal Microbiota Transplantation by Colonoscopy for Recurrent C. Difficile Infectiontreatment2completed
NCT03654872
Clostridium Difficile Virulence Mechanism Study (CDVM Study)No drug interventionsNot AvailableNot Availableunknown_status
NCT01143272
Probiotic Saccharomyces Boulardii for the Prevention of Antibiotic-associated Diarrhoeaprevention3terminated
NCT03617172
PROCLAIM -- Misoprostol in the Prevention of Recurrent CDI Prevent Recurrence of Clostridium Difficile Infection With Misoprostolprevention2terminated
NCT00417872
Study of Nitazoxanide in the Treatment of Clostridium Difficile Colitistreatment2completed
NCT06071312
FMT in Patients With Recurrent CDI and Ulcerative Colitis: Single Infusion Versus Sequential ApproachNo drug interventionstreatment1 / 2recruiting
NCT02951481
Antimicrobial Stewardship Program for Clostridium Difficile Infection.No drug interventionsNot AvailableNot Availablecompleted
NCT00506181
Probiotics: is it Really That Good? Cost-Effectiveness of Treating the in-Patientprevention3unknown_status
NCT02127814
Lactobacillus Reuteri in the Prevention of Antibiotic Associated-diarrhea and Clostridium DifficileNo drug interventionspreventionNot Availablecompleted
NCT01401023
Pharmacokinetics and Safety of Tigecycline in the Treatment of Clostridium Difficile Associated Diarrhea (CDAD)treatmentNot Availablecompleted
NCT02355938
Use Of Oral Fidaxomicin Vs. Oral Vancomycin For Clostridium Difficile Infection In Patients With Spinal Cord Injurytreatment4terminated
NCT04100603
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Clostridoides Difficile InfectionNo drug interventionsNot AvailableNot Availableunknown_status
NCT04729790
Randomized Clinical Trial of Standard FMT TreatmentsNo drug interventionstreatment2withdrawn
NCT03857464
C Difficile Near-patient DiagnosticsNo drug interventionsdiagnosticNot Availablecompleted
NCT05622721
REMBRANDT: REcovery of the MicroBiome fRom Antibiotics for Dental implanTsNo drug interventionsNot AvailableNot Availablerecruiting
NCT06258551
Dynamics of Colonization and Infection by Multidrug-Resistant Pathogens in Immunocompromised and Critically Ill PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT02133651
Mucosal Versus Fecal Microbiota in FMTNo drug interventionsNot AvailableNot Availablecompleted
NCT01942447
Fecal Microbiota Transplantation in Recurrent or Refractory Clostridium Difficile ColitistreatmentNot Availableunknown_status
NCT01775397
A Post-marketing, Blinded Study to Investigate How Effective Fidaxomicin is Compared to Vancomycin in the Sustained Cure of Clostridium Difficile Infection in Adults That Are Receiving Therapy to Suppress the Immune Systemtreatment4terminated
NCT00377078
Use of Recombinant Human Lactoferrin in Long-Term Care Patients With Feeding Tubes With Clostridium Difficile.preventionNot Availableunknown_status
NCT02797288
Immune Response to C.Difficile InfectionNo drug interventionsNot AvailableNot Availablerecruiting
NCT02801656
Fecal Microbiota Transplantation for Primary Clostridium Difficile Diarrheatreatment3withdrawn
NCT03223415
Effectiveness of Isolating Clostridium Difficile Asymptomatic Carriers on the Incidence of InfectionsNo drug interventionspreventionNot Availablecompleted
NCT01813500
Host Immune Response to Clostridium Difficile Infection in Inflammatory Bowel Disease PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT00566306
Influence of a New Polycationic Disinfectant on Clostridium Difficile Incidence and Environmental ColonisationNo drug interventionspreventionNot Availablecompleted
NCT03586206
Relationship Between C. Difficile Toxins' Serum Level With C. Difficile InfectionNo drug interventionsNot AvailableNot Availableunknown_status
NCT02563106
A Study of SYN-004 for the Prevention of C.Diff in Patients With a LRTIprevention2completed
NCT02636517
Fecal Microbiome Transplanttreatment1recruiting
NCT02747017
Observational Study of C. Diff in Post-Transplant PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT04171817
Animal-Assisted Visitation Program Chlorhexidine Trialprevention4recruiting
NCT03788434
Phase 2 Study of VE303 for Prevention of Recurrent Clostridioides Difficile Infectionprevention2completed
NCT04036058
Effect of Expanding (Gloving) Barrier Precautions for Reducing Clostridium Difficile Acquisition (and Infection) in VANo drug interventionshealth_services_researchNot Availableactive_not_recruiting
NCT00466635
A Study to Assess the Safety, Tolerability, Effectiveness and Absorption of Exodif™ Tablets in Clostridium Difficile-associated Diarrheatreatment3terminated
NCT02403622
Safety of FMT: OpenBiome Outcomes and Longitudinal Follow-up (STOOL) for Recurrent Clostridium Difficile Infectiontreatment2terminated
NCT02730325
To Evaluate the Impact of SBI on C. Difficile in Hospitalized UC PatientsNo drug interventionsotherNot Availableterminated
NCT01959048
Efficacy and Safety of Fecal Microbiota Transplantation for Severe Clostridium Difficile Associated ColitistreatmentNot Availableterminated
NCT01973465
Fecal Microbiota Therapy for Recurrent Clostridium Difficile ColitistreatmentNot Availableunknown_status
NCT02063282
The Risk for Clostridium Difficile Colitis During Hospitalization in Asymptomatic CarriersNo drug interventionsNot AvailableNot Availablecompleted
NCT02774382
Rectal Bacteriotherapy, Fecal Microbiota Transplantation or Oral Vancomycin Treatment of Recurrent Clostridium Difficile Infectionstreatment3unknown_status
NCT02502682
Chlorhexidine Bathing Effect on Clostridium Difficile Ratesprevention2completed
NCT02857582
Transplantation of Cultured Gut Microflora to Repeat Antibiotic-induced Diarrhea Due to Clostridium Difficiletreatment2completed
NCT01901276
Effects of Gastric Acid on Colonic Microbiomebasic_science4completed
NCT02247960
Antibiotic Prophylaxis for Urinary Catheter Removal After Radical ProstatectomytreatmentNot Availableterminated
NCT01703494
Fecal Transplant for Relapsing C. Difficile Infectiontreatment2unknown_status
NCT03427229
Fecal Microbiota Transplantation for Severe Clostridium Difficile Infectiontreatment2completed
NCT02134392
Fecal Transplant for Pediatric Patients Who Have Recurrent C-diff Infectiontreatment1recruiting
NCT02423967
Fresh Versus Frozen Stool for Fecal Transplant in ChildrenNo drug interventionstreatment1completed
NCT01048567
Efficacy and Safety of Lactobacillus Acidophilus/Rhamnosus Combination for the Prevention of Antibiotic-associated Diarrhea in the ElderlyNo drug interventionsprevention2terminated
NCT03889808
Seroprevalence of Anti-bodies Against Clostridium Difficile Toxins and Prevalence of Asymptomatic Carriage of Clostridium Difficile in IBD Patients.No drug interventionsNot AvailableNot Availableunknown_status