Clostridium difficile infection recurrence (DBCOND0024824)

Identifiers

Synonyms

Recurrence of Clostridium Difficile Infection / Recurrent Clostridium Difficile Infection / Recurrent infection caused by Clostridioides difficile (disorder) / Clostridioides difficile infection / Clostridium difficile Infections / Clostridium difficile infection / Infection caused by Clostridioides difficile (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Bezlotoxumab	A monoclonal antibody used to reduce the recurrence of Clostridium difficile infections.	Toxin Btarget
Rifaximin	A rifamycin-based non-systemic antibiotic used for the treatment of gastrointestinal bacterial infections, such as traveler's diarrhea and irritable bowel syndrome, and reduction of overt hepatic encephalopathy recurrence in adults.	DNA-directed RNA polymerase subunit betatarget Nuclear receptor subfamily 1 group I member 2target Cytochrome P450 3A4enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05835219	REBYOTA™ Prospective Registry	Fecal microbiota	Not Available	Not Available	recruiting
NCT06237452	VE303 for Prevention of Recurrent Clostridioides Difficile Infection	VE303	prevention	3	recruiting
NCT03110133	Efficacy, Safety, and Tolerability Study of Oral Full-Spectrum MicrobiotaTM (CP101) in Subjects With Recurrent C. Diff	No drug interventions	prevention	2	completed
NCT03617445	Fecal Microbiota Transplantation for C. Difficile Infection in Solid Organ Transplant Recipients	Vancomycin	treatment	2	completed
NCT05606159	Bacillus Velezensis DSM 33864 for Reduction of the Risk of Recurrent Clostridioides Difficile Infections	No drug interventions	supportive_care	Not Available	not_yet_recruiting
NCT04415918	Bezlotoxumab Efficacy and Tolerability in Cancer Patient	Bezlotoxumab	prevention	4	unknown_status
NCT04317963	Real-world Evaluation of Bezlotoxumab for the Management of Clostridioides Difficile Infection	Bezlotoxumab	Not Available	Not Available	completed
NCT03880539	Bezlotoxumab (BEZLO) In Addition To Standard Of Care (SOC) Vancomycin For The Treatment of Multi-Recurrent Clostridium Difficile Infection	Bezlotoxumab Vancomycin	treatment	4	completed
NCT05831189	A Multi-center, Single-arm Trial Exploring the Safety and Clinical Effectiveness of RBX2660 Administered by Colonoscopy to Adults With Recurrent Clostridioides Difficile Infection	Fecal microbiota	treatment	3	active_not_recruiting
NCT03562741	Outcomes and Data Collection for Fecal Microbiota Transplantation for the Treatment of Recurrent Clostridium Difficile	No drug interventions	treatment	Not Available	recruiting
NCT03788434	Phase 2 Study of VE303 for Prevention of Recurrent Clostridioides Difficile Infection	VE303	prevention	2	completed
NCT04891965	A Study of ART24 in Subjects Recently Cured of a Clostridioides Difficile Infection (CDI)	No drug interventions	prevention	1	completed
NCT03065374	Treatment for Clostridium-difficile Infection With IMM529	No drug interventions	treatment	1 / 2	terminated
NCT04000555	Oral Vancomycin for Secondary Prophylaxis of Clostridium Difficile Infection (CDI)	Vancomycin	prevention	4	terminated
NCT05826418	Dietary Optimization of Microbiome Recovery Following Fecal Microbiota Transplantation	No drug interventions	supportive_care	Not Available	recruiting
NCT05201079	Primary or Recurrent Clostridioides Difficile Infection Treatment With Capsules of Lyophilised Faecal Microbiota vs Fidaxomicin	Fecal microbiota Fidaxomicin	treatment	3	completed
NCT03973697	Penn Microbiome Therapy for Recurrent Clostridium Difficile Infection	No drug interventions	treatment	2	terminated
NCT03786900	Fecal Microbiota Transplantation (FMT): PRIM-DJ2727	Fecal microbiota	Not Available	Not Available	available
NCT03462459	Efficacy of Oral Vancomycin Prophylaxis for Prevention of Recurrent Clostridium Difficile Infection	Vancomycin	prevention	2	completed
NCT03353506	Lyophilized Fecal Transplant vs Lyophilized Fecal Filtrate in Recurrent C Diff Infection	No drug interventions	treatment	2	completed
NCT04960306	Fecal Filtrate as a Treatment Option of Multiple Recurrent Clostridioides Difficile Infection	Fecal microbiota	treatment	3	not_yet_recruiting
NCT01925417	Microbiota Restoration Therapy for Recurrent Clostridium Difficile-associated Diarrhea	No drug interventions	treatment	2	completed
NCT01202630	BIO-K+ CL1285 for Prevention of Recurrent Clostridium Difficile Infection	No drug interventions	prevention	3	suspended
NCT01226992	Oral Vancomycin Followed by Fecal Transplant Versus Tapering Oral Vancomycin	Vancomycin	treatment	2 / 3	terminated
NCT03497806	Open-Label Extension of CP101 Trials Evaluating Oral Full-Spectrum Microbiota™ (CP101) in Subjects With Recurrence of Clostridium Difficile Infection	No drug interventions	treatment	2	completed