Steroid Refractory Acute Graft Versus Host Disease (DBCOND0079125)

Identifiers

Synonyms

Steroid-refractory Acute Graft-versus-Host Disease / Steroid-Refractory Acute Graft Versus Host Disease

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Alemtuzumab	A monoclonal anti-CD52 antibody used in the treatment of B-cell chronic lymphocytic leukemia and relapsing forms of multiple sclerosis.	CAMPATH-1 antigentarget Low affinity immunoglobulin gamma Fc region receptor III-Btarget Low affinity immunoglobulin gamma Fc region receptor III-Atarget High affinity immunoglobulin gamma Fc receptor Itarget Low affinity immunoglobulin gamma Fc region receptor II-atarget Low affinity immunoglobulin gamma Fc region receptor II-btarget Low affinity immunoglobulin gamma Fc region receptor II-ctarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06462469	Study of Efficacy and Safety of Ruxolitinib in Patients With Grade II to IV Steroid-refractory Acute Graft vs. Host Disease	Ruxolitinib	treatment	4	recruiting
NCT04934670	A Study to Compare T-Guard vs Ruxolitinib for Treatment of Steroid-Refractory Acute Graft-vs-Host Disease (BMT CTN 2002)	Ruxolitinib T-Guard	treatment	3	terminated
NCT04128319	T-Guard as Treatment for Steroid Refractory Acute GVHD (BMT CTN 1802)	T-Guard	treatment	3	terminated
NCT04629833	Treatment Of Steroid-Refractory Acute Graft-versus-host Disease With Mesenchymal Stromal Cells Versus Best Available Therapy	No drug interventions	treatment	3	recruiting
NCT06075706	Trial of Efficacy and Safety of MC0518 Versus Best Available Therapy in Participants With Steroid-Refractory Acute Graft Versus Host Disease	No drug interventions	treatment	2	recruiting
NCT03327857	Neihulizumab (ALTB-168) in Patients With Steroid-refractory Acute Graft-versus-host Disease or Treatment-refractory Acute Graft-versus-host Disease	Neihulizumab	treatment	1	completed
NCT02524847	Methoxsalen and Extracorporeal Photopheresis (ECP) for the Treatment of Pediatric Participants With Steroid Refractory Acute Graft Versus Host Disease	Methoxsalen	treatment	3	terminated
NCT03172455	Early Access Program Using Alpha 1 Antitrypsin Infusion for Patients With Steroid Refractory Acute GvHD After Hematopoietic Stem Cell Transplantation (HSCT)	Alpha-1-proteinase inhibitor Benzalkonium	Not Available	Not Available	no_longer_available