Cough caused by Common Cold (DBCOND0121935)

Identifiers

Synonyms

Not Available

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Acetaminophen	An analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Cytochrome P450 1A2enzyme Cytochrome P450 2E1enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2D6enzyme Cytochrome P450 2A6enzyme Cytochrome P450 3A4enzyme UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1-6enzyme UDP-glucuronosyltransferase 1A9enzyme UDP-glucuronosyltransferase 2B15enzyme Sulfotransferase 1A1enzyme Sulfotransferase 1A3enzyme Arylamine N-acetyltransferase 2enzyme Prostaglandin E synthase 3target Transient receptor potential cation channel subfamily V member 1target Albumincarrier Fatty-acid amide hydrolase 1enzyme Glutathione S-transferase Penzyme Glutathione S-transferase Mu 1enzyme Sodium-dependent noradrenaline transportertarget Sodium-dependent serotonin transportertarget
Ammonium chloride	Expectorant in cough syrups. The ammonium ion (NH4+) in the body plays an important role in the maintenance of acid-base balance. The kidney uses ammonium (NH4+) in place of sodium...	No drug targets
Bromhexine	A mucolytic drug used to decrease the viscosity of mucus in the airway, enhancing mucus clearance.	Transmembrane protease serine 2target Angiotensin-converting enzyme 2target Angiotensin-converting enzyme 2enzyme
Brompheniramine	A histamine H1 antagonist used to treat coughs, upper respiratory symptoms, and nasal congestion associated with allergies and the common cold.	Histamine H1 receptortarget Muscarinic acetylcholine receptor M1target Muscarinic acetylcholine receptor M2target Muscarinic acetylcholine receptor M3target Muscarinic acetylcholine receptor M4target Muscarinic acetylcholine receptor M5target
Chlorpheniramine	A histamine-H1 receptor antagonist indicated for the management of symptoms associated with upper respiratory allergies.	Histamine H1 receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 2D6enzyme Sodium-dependent serotonin transportertarget Sodium-dependent noradrenaline transportertarget Sodium-dependent dopamine transportertarget Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter
Dextromethorphan	An NMDA receptor antagonist used to treat cases of dry cough.	Sigma non-opioid intracellular receptor 1target Neuronal acetylcholine receptor subunit alpha-2target Sodium-dependent serotonin transportertarget Glutamate receptor ionotropic, NMDA 3Atarget Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A7enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Membrane-associated progesterone receptor component 1target Neuronal acetylcholine receptor subunit alpha-3target Neuronal acetylcholine receptor subunit alpha-4target Neuronal acetylcholine receptor subunit beta-4target Neuronal acetylcholine receptor subunit beta-2target Neuronal acetylcholine receptor subunit alpha-7target Mu-type opioid receptortarget Delta-type opioid receptortarget Kappa-type opioid receptortarget NADPH oxidasetarget Sodium-dependent noradrenaline transportertarget UDP-glucuronosyltransferase 2B4enzyme UDP-glucuronosyltransferase 2B7enzyme UDP-glucuronosyltransferase 2B15enzyme UDP-glucuronosyltransferase 2B17enzyme Aromatasetarget
Diphenhydramine	A H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes.	Histamine H1 receptortarget Cytochrome P450 2D6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Solute carrier family 22 member 2transporter Organic cation/carnitine transporter 2transporter Prostaglandin G/H synthase 1enzyme Muscarinic acetylcholine receptor M2target Histamine N-methyltransferasetarget
Guaifenesin	An expectorant commonly found in OTC products for the symptomatic relief from congested chests and coughs associated with cold, bronchitis, and/or other breathing illnesses.	NMDA receptortarget
Hydrocodone	An opioid agonist used as an analgesic and antitussive agent.	Mu-type opioid receptortarget Delta-type opioid receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 2D6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Sigma non-opioid intracellular receptor 1target
Ipecac	An emetic agent used to induce vomiting in poisoning.	Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme
Levomenthol	An organic compound used to treat mild to moderate muscle and joint pain.	Transient receptor potential cation channel subfamily A member 1target Transient receptor potential cation channel subfamily M member 8target Transient receptor potential cation channel subfamily V member 3target Kappa-type opioid receptortarget Voltage-dependent L-type calcium channeltarget Cytochrome P450 3A4enzyme
Phenylephrine	An alpha-1 adrenergic agonist used in the management of hypotension, generally in the surgical setting associated with the use of anesthetics.	Alpha-1A adrenergic receptortarget Alpha-1B adrenergic receptortarget Amine oxidase [flavin-containing] Aenzyme Alpha-1D adrenergic receptortarget Cytochrome P450 1A2enzyme Sulfotransferase 1A3enzyme Amine oxidase [flavin-containing] Benzyme D(2) dopamine receptortarget
Pholcodine	An opioid antitussive used to suppress unproductive coughing.	Mu-type opioid receptortarget Kappa-type opioid receptortarget Delta-type opioid receptortarget
Potassium guaiacolsulfonate	A mucolytic and expectorant indicated to relieve a productive cough.	No drug targets
Pseudoephedrine	An alpha and beta adrenergic agonist used to treat nasal and sinus congestion, as well as allergic rhinitis.	Alpha-1A adrenergic receptortarget Alpha-2A adrenergic receptortarget Beta-2 adrenergic receptortarget Amine oxidase [flavin-containing] Aenzyme Beta-1 adrenergic receptortarget Sodium-dependent dopamine transportertarget Sodium-dependent noradrenaline transportertarget Sodium-dependent serotonin transportertarget Nuclear factor of activated T-cells, cytoplasmic 1target Tumor necrosis factortarget Nuclear factor NF-kappa-B p105 subunittarget activator protein 1target Interleukin-2target Albumincarrier Sodium-dependent noradrenaline transportertransporter Sodium-dependent dopamine transportertransporter Sodium-dependent serotonin transportertransporter D(2) dopamine receptortarget
Terpin hydrate	An expectorant used to treat bronchitis, pneumonia, bronchiectasis, COPD, and infectious or inflammatory diseases of the upper respiratory tract.	No drug targets

Clinical Trials

Not Available