Amoxapine

DB00543ApprovedSmall moleculeAntidepressive Agents Indicated for DepressionAntidepressive Agents, Tricyclic

Amoxapine is a tricyclic antidepressant used in the treatment of neurotic or reactive depressive disorders and endogenous or psychotic depression. Amoxapine, the N-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA).

Chemical structure of Amoxapine
Mechanism
Curator reviewed
Primary indication
For the relief of symptoms of depression in patients with neurotic or reactive depressive disorders as well as endogenous and psychotic depressions.Curator reviewed · 6 structured indications
Formula / weight
C17H16ClN3O · 313.781 g/mol (avg)
First approval
Canada, 1981 · United States, 1991
Also known as
Desmethylloxapin
Code names
CL-67,772

Resolves to

Compound
UNIIR63VQ857OTCAS14028-44-5ChEMBLCHEMBL1113ChEBI2675PubChem2170KEGGD00228
Clinical / RWD
RxNorm722ATCN06AA17PharmGKBPA448405
Structure
InChIKeyQWGDMFLQWFTERH-UHFFFAOYSA-NSMILESClC1=CC2=C(OC3=CC=CC=C3N=C2N2CCNCC2)C=C1
Targets
P31645SLC6A4P23975SLC6A2P14416DRD2P21728DRD1P08913ADRA2AP35348ADRA1AP11229CHRM1P14867GABRA1+13 more

What you can answer from here — as of September 20, 2026

26Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
1,837Drug interactionsStructured to mechanism, not free text
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6Structured indicationsCondition, population, route and combination as fields, not prose
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2ContraindicationsEach with its own population and attribute set
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17Marketed productsAcross 3 countries and 6 labellers
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1ATC codeIncluding every combination product, plus 53 drug categories
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65+ReferencesStructured and connected to the statements they support
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