Tetracycline is an antibiotic used to treat a wide variety of susceptible infections. Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria.
- Mechanism
- Curator reviewed
Tetracycline passively diffuses through porin channels in the bacterial membrane and reversibly binds to the 30S ribosomal subunit, preventing binding of tRNA to the mRNA-ribosome complex, and thus interfering with protein synthesis.
- Primary indication
- Used to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, tick fevers, Q fever, rickettsialpox and Brill-Zinsser disease.Curator reviewed · 50 structured indications
- Formula / weight
- C22H24N2O8 · 444.4346 g/mol (avg)
- First approval
- Canada, 1997 · United States, 1975
- Also known as
- Abramycin · Anhydrotetracycline · Deschlorobiomycin · Tsiklomitsin
- Brand names
Resolves to
Structure
InChIKey
OFVLGDICTFRJMM-WESIUVDSSA-NSMILES[H][C@@]12C[C@@]3([H])C(=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C)C(=O)C1=C(O)C=CC=C1[C@@]3(C)OWhat you can answer from here — as of September 23, 2026
7Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
5TransportersSubstrate / inhibitor direction, not just membershipListed above
Which drugs share a target with Tetracycline, and which of those have an active Phase 3 trial?
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