Antipsychotic Agents
- Name
- Antipsychotic Agents
- Accession Number
- DBCAT000529
- Description
Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.
- ATC Classification
- Drugs
Drug Drug Description Ziprasidone An atypical antipsychotic used to manage schizophrenia, bipolar mania, and agitation in patients with schizophrenia. Olanzapine An antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders. Clozapine An antipsychotic drug used in treatment resistant schizophrenia and to decrease suicide risk in schizophrenic patients. Sulpiride A selective D2 dopamine receptor antagonist indicated to treat chronic and acute schizophrenia. Loxapine A antipsychotic used for the treatment of schizophrenia. Remoxipride An discontinued atypical antipsychotic selective for dopamine D2 receptors. Promazine A phenothiazine used to manage schizophrenia. Prochlorperazine A phenothiazine derivative used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting. Droperidol A butyrophenone derivative and dopamine antagonist used to prevent and treat postoperative nausea and vomiting. Chlorpromazine A phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. Haloperidol An antipsychotic agent used to treat schizophrenia and other psychoses, as well as symptoms of agitation, irritability, and delirium. Triflupromazine Used mainly in the management of psychoses. Also used to control nausea and vomiting. Fluphenazine A phenothiazine used to treat patients requiring long-term neuroleptic therapy. Thioridazine A phenothiazine antipsychotic used to treat schizophrenia and generalized anxiety disorder. Risperidone A second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression. Trifluoperazine A phenothiazine used to treat depression, anxiety, and agitation. Perphenazine A phenothiazine used to treat schizophrenia as well as nausea and vomiting. Flupentixol A thioxanthene neuroleptic used to treat schizophrenia and depression. Mesoridazine A phenothiazine antipsychotic used to treat schizophrenia, organic brain disorders, alcoholism, and psychoneuroses. Pimozide An antipsychotic used to manage debilitating motor and phonic tics in patients with Tourette's Disorder. Quetiapine A psychotropic agent used for the management of bipolar disorder, schizophrenia, and major depressive disorder. Aripiprazole An atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome. Chlorprothixene A thioxanthene antipsychotic. Paliperidone An atypical antipsychotic used in the treatment of schizophrenia and other schizoaffective or delusional disorders. Methotrimeprazine A phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder. Acepromazine Acepromazine was first used in humans in the 1950s as an antipsychotic agent. It is now rarely used in humans. Acepromazine is frequently used in animals as a sedative and... Molindone An antipsychotic used to treat schizophrenia. Thiothixene An antipsychotic indicated for the management of schizophrenia. Zuclopenthixol An antipsychotic indicated for the management of schizophrenia. The acuphase formulation is indicated for initial treatment of acute psychosis or exacerbation of psychosis, while the depot formulation is best for maintenance. Fluspirilene An antipsychotic agent used in the treatment of schizophrenia. Sertindole An atypical antipsychotic indicated in the treatment of schizophrenia. Asenapine An atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia. Amisulpride A dopamine D2 receptor antagonist used in the treatment of acute and chronic schizophrenia, and in the prevention and treatment of postoperative nausea and vomiting in adults. Lurasidone An atypical antipsychotic used to treat schizophrenia and depressive episodes associated with bipolar I disorder. Cyamemazine Cyamemazine (Tercian), also known as cyamepromazine, is a typical antipsychotic drug of the phenothiazine class used primarily in the treatment of schizophrenia and psychosis-associated anxiety. Cyamemazine actually behaves like an... Melperone An atypical butyrophenone antipsychotic used to treat sleep disorders, confusion, and psychomotor dysfunction associated with geriatric, psychiatric, and alcohol-dependent patients. Zotepine Zotepine, like other atypical antipsychotics, is considered as the first-line treatment in newly diagnosed schizophrenia. It is usually thought to be an option of choice for managing acute schizophrenic episodes... Pipamperone Treatment of chronic psychoses and states of aggressiveness of various origins . Perazine A phenothiazine antipsychotic used in the acute and chronic treatment of psychotic disorders. Benperidol A neuroleptic butyrophenone derivative indicated in the treatment of psychoses, manic episodes, and psychomotor agitation. Tiapride A dopamine D2 and D3 receptor antagonist indicated in the treatment of chorea in Huntington's disease, as well as agitation and anxiety in the elderly or with acute or chronic alcoholism. Bromperidol A first-generation butyrophenone antipsychotic used in the treatment of schizophrenia and other psychotic manifestations. Clothiapine An atypical antipsychotic indicated in the treatment of acute psychosis, exacerbations of chronic psychosis, chronic psychosis, paranoid psychosis, and anxiety. Sultopride Sultopride is used in Japan, Hong Kong, and Europe to treat schizophrenia. It is of the drug class atypical antipsychotics . Trifluperidol Not Annotated Fluanisone Not Annotated Dixyrazine Not Annotated Penfluridol Not Annotated Clopenthixol Clopenthixol is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors. Veralipride Not Annotated Reserpine For the treatment of hypertension Dapiprazole Used in the treatment of iatrogenically induced mydriasis produced by adrenergic (phenylephrine) or parasympatholytic (tropicamide) agents used in certain eye examinations. Aceprometazine Aceprometazine is often used in combination with meprobamate for the treatment of sleep disorders. Osanetant Potential therapy for schizophrenia, depression and visceral pain. Bifeprunox Bifeprunox is being evaluated for the treatment of schizophrenia, psychosis, and Parkinson's disease. Perospirone For the treatment of schizophrenia and acute cases of bipolar mania. Amperozide Amperozide is a diphenylbutylpiperazine atypical antipsychotic which antagonizes 5-HT2A receptors. It inhibits dopamine release and alters the firing of dopaminergic neurons. Investigations regarding the use of the agent revolved primarily... Azaperone Azaperone is a pyridinylpiperazine and butyrophenone agent that is capable of eliciting neuroleptic sedative and antiemetic effects. It is subsequently employed predominantly as a veterinary tranquilizer and mainly for pigs... Tetrahydropalmatine Tetrahydropalmatine is under investigation in clinical trial NCT02118610 (Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity). Ecopipam Ecopipam has been used in trials studying the treatment of Tourette's Syndrome, Lesch-Nyhan Disease, Pathological Gambling, and Self-injurious Behavior. Raclopride Raclopride has been used in trials studying Parkinson Disease. Acetophenazine For the treatment of disorganized and psychotic thinking. Also used to help treat false perceptions (e.g. hallucinations or delusions.) Lithium cation A drug used for the management of bipolar disorder and other psychiatric conditions. Periciazine A phenothiazine used with other medications to treat aggressiveness, impulsiveness, and hostility associated with psychiatric conditions such as schizophrenia. Pipotiazine An antipsychotic indicated for the management of chronic, non-agitated schizophrenic patients. Thioproperazine An antipsychotic indicated for the management of acute and chronic schizophrenia, including cases that are refractory to more common neuroleptics. May also be used to treat manic syndromes. Iloperidone An atypical antipsychotic agent used for the acute treatment of schizophrenia in adults. Cariprazine An atypical antipsychotic used to treat schizophrenia and acute manic or mixed episodes due to bipolar I disorder. Brexpiprazole A serotonin–dopamine activity modulator used in the treatment of major depressive disorder as an adjunct and schizophrenia. Prothipendyl A neuroleptic agent indicated in the treatment of restlessness and agitation in patients with underlying psychiatric conditions. Butaperazine Butaperazine was approved in 1967 , and possibly discontinued in the 1980s . Chlorproethazine Not Annotated Oxypertine Not Annotated Moperone Not Annotated Thiopropazate Not Annotated Mosapramine Not Annotated Amoxapine A tricyclic antidepressant used in the treatment of neurotic or reactive depressive disorders and endogenous or psychotic depression. Promethazine A first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness. Thiethylperazine A drug used for the treatment of nausea and vomiting. Moricizine An antiarrhythmic used to treat arrhythmias. Alimemazine An antihistamine agent used to prevent and relieve allergic conditions which cause pruritus and other allergic skin conditions, including urticaria. BL-1020 Investigated for use/treatment in schizophrenia and schizoaffective disorders. Methylene blue An oxidation-reduction agent used for the treatment of pediatric and adult patients with acquired methemoglobinemia. Propiopromazine Not Annotated Thiazinam Not Annotated Blonanserin Used for the treatment of schizophrenia . Lumateperone A novel 2nd generation antipsychotic used to manage both positive and negative symptoms in patients with schizophrenia. Brilaroxazine Investigated for the treatment of schizophrenia and schizoaffective disorder. Ritanserin Ritanserin has been used in trials studying the treatment of Cocaine-Related Disorders. Aripiprazole lauroxil An antipsychotic used to treat schizophrenia in adults. Perphenazine enanthate Not Annotated Levosulpiride indicated to treat dyspepsia, symptoms of Meniere's syndrome, and second line in the treatment of drug-induced nausea and vomiting. - Drugs & Drug Targets