Antidepressive Agents, Tetracyclic
- Name
- Antidepressive Agents, Tetracyclic
- Accession Number
- DBCAT003850
- Description
Substances that contain a fused four-ring moiety and are used in the treatment of depression. These drugs have diverse pharmacology and may inhibit the reuptake of norepinephrine, as well as block certain subtypes of serotonin, adrenergic, and histamine receptors. Compared to tricyclic antidepressants, these tend to be stronger antihistamines and have less anticholinergic side effects.
- Drugs
Drug Drug Description Maprotiline A tetracyclic antidepressant used to treat depressive illness, major depressive disorder, bipolar disorder, and anxiety associated with depression. Mianserin A tetracyclic antidepressant with therapeutic activity similar to amitriptyline used to treat depression and anxiety. Mirtazapine A tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite. Setiptiline For the treatment of depression . Amoxapine A tricyclic antidepressant used in the treatment of neurotic or reactive depressive disorders and endogenous or psychotic depression. Aptazapine Investigated for the treatment of depression. Esmirtazapine Investigated for use/treatment in insomnia and sleep disorders. Oxaprotiline Investigated for the treatment of depression. - Drugs & Drug Targets