Genital Herpes (DBCOND0030497)

Identifiers

Synonyms

Genital herpes / Herpes Genitalis / Genital herpes simplex (disorder) / Genital herpes simplex / Genital herpes, unspecified / Herpes genital

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Valaciclovir	An guanine nucleoside antiviral used to treat herpes exacerbations.	Thymidine kinasetarget DNA polymerase catalytic subunittarget Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Organic anion transporter 3transporter Solute carrier family 22 member 6transporter Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)transporter Ileal sodium/bile acid cotransportertransporter Guanylate kinaseenzyme Thymidine kinaseenzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06033261	A Study of mRNA-1608, a Herpes Simplex Virus -2 (HSV-2) Therapeutic Candidate Vaccine, in Healthy Adults 18 to 55 Years of Age With Recurrent HSV-2 Genital Herpes	Neisseria meningitidis serogroup B strain NZ98/254 outer membrane vesicle Neisseria meningitidis serogroup b fhbp fusion protein antigen Neisseria meningitidis serogroup b nada protein antigen Neisseria meningitidis serogroup b nhba fusion protein antigen	treatment	1 / 2	active_not_recruiting
NCT03146403	Maintenance Dose Study of GEN-003 in Subjects With Genital Herpes Infection	No drug interventions	treatment	2	terminated
NCT01390805	Special Drug Use Investigation for VALTREX (Valaciclovir) (Suppression Prophylaxis)	Valaciclovir	Not Available	Not Available	completed
NCT03080961	The VIBLOK SAfety and perFormancE Trial	No drug interventions	prevention	Not Available	completed
NCT01112956	Serologic Assays for the Diagnosis of Herpes Simplex Virus Type 2	No drug interventions	Not Available	Not Available	completed
NCT04222985	Safety and Efficacy of 4 Investigational HSV 2 Vaccines in Adults With Recurrent Genital Herpes Caused by HSV 2	Sodium chloride	treatment	1	terminated
NCT01346475	Randomized Trial to Evaluate Suppressive Effect of High-Dose Valacyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2	Valaciclovir	treatment	4	completed
NCT00231049	Trial Evaluating Safety, Tolerability and Immune Response of AG-707	No drug interventions	treatment	1	completed
NCT00129818	A Study to Evaluate the Effect of Famciclovir in Reducing Herpes Virus Shedding	Famciclovir	treatment	4	completed
NCT00477334	Patient-initiated Episodic Treatment of Recurrent Genital Herpes in Black Patients	Famciclovir	treatment	4	completed
NCT01658826	Safety and Efficacy Comparator Trial of a New Drug Against Genital Herpes	Pritelivir Valaciclovir	prevention	2	terminated
NCT00723229	A Randomized Trial to Evaluated the Suppressive Effect of Acyclovir on Rapidly Cleared HSV-2 Reactivation	Acyclovir	treatment	4	completed
NCT00306787	Efficacy and Safety of Famciclovir 1-day Treatment Compared to 3-day Treatment With Valacyclovir in Adults With Recurrent Genital Herpes	Famciclovir Valaciclovir	treatment	3	completed
NCT05500053	A Study of the Characteristics of Patients Diagnosed With Recurrent Symptomatic Genital Herpetic Disease	No drug interventions	Not Available	Not Available	completed
NCT00808405	GUD Clinical and Virologic Response to Acyclovir in HIV Negative African Women	Acyclovir	treatment	Not Available	completed
NCT00362297	Randomized Trial to Evaluate Suppressive Effect of High-Dose Acyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2	Acyclovir Valaciclovir	treatment	4	completed
NCT05675228	Knowledge of Young Adults About Genital Herpes	No drug interventions	Not Available	Not Available	recruiting
NCT00124878	Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community	No drug interventions	prevention	3	unknown_status
NCT01281007	Efficacy of Oral Famciclovir 125mg Comparing to Aciclovir 200 mg Treatment in Patients With Active Recurrent Genital Herpes	Acyclovir Famciclovir	treatment	3	completed
NCT00262106	Trial to Evaluate PRO 2000/5 Gels for the Prevention of Vaginally Acquired HIV Infection	PRO 2000	prevention	3	completed
NCT00527618	Trial to Study the Effect of Dose of Herpes Simplex Virus-2 (HSV-2) Suppressive Therapy on HSV and HIV	Acyclovir Valaciclovir	treatment	4	completed
NCT01132716	Bioequivalency Study of Valacyclovir Hydrochloride 1000 mg Under Fed Conditions	Valaciclovir	treatment	Not Available	completed
NCT00495716	Effect of HSV-2 Suppressive Therapy on Sexual Behavior	Acyclovir	other	4	terminated
NCT03831165	Melatonin Effects on Genital Herpes in Brazilian Women	Acyclovir Melatonin	treatment	4	completed
NCT00495573	HSV-2 Shedding Resolution After Acyclovir Treatment	Acyclovir	Not Available	Not Available	completed
NCT01132729	Bioequivalency Study of Valacyclovir Hydrochloride 1000 mg Under Fasting Conditions	Valaciclovir	treatment	Not Available	completed
NCT03595995	A Phase 2 Trial to Evaluate the Safety and Efficacy of UB-621	No drug interventions	treatment	2	unknown_status
NCT01765114	A Study to Investigate the Efficacy, Safety and Tolerability of PEG in Patients With Genital Herpes	No drug interventions	treatment	2	terminated