Herpes Labialis (DBCOND0000240)

Identifiers

Synonyms

Orofacial herpes / Herpes labialis / Herpesviral vesicular dermatitis / Herpes simplex labialis / Herpes labialis (disorder) / Cold sores / Fever blister / Cold sores lip / Herpes on lip / Cold sore (herpetic) / Fever sore / Oral herpes simplex infection (disorder) / Oral herpes

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Hydrocortisone	A glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders.	Annexin A1target Glucocorticoid receptortarget Sex hormone-binding globulincarrier Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 11B2, mitochondrialenzyme Cytochrome P450 2C8enzyme Corticosteroid-binding globulincarrier Organic anion transporter 3transporter Aldo-keto reductase family 1 member D1enzyme 3-oxo-5-alpha-steroid 4-dehydrogenase 2enzyme 11-beta-hydroxysteroid dehydrogenase type 2enzyme 11-beta-hydroxysteroid dehydrogenase 1enzyme Cytochrome P450 2A6enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme
Valaciclovir	An guanine nucleoside antiviral used to treat herpes exacerbations.	Thymidine kinasetarget DNA polymerase catalytic subunittarget Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Organic anion transporter 3transporter Solute carrier family 22 member 6transporter Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)transporter Ileal sodium/bile acid cotransportertransporter Guanylate kinaseenzyme Thymidine kinaseenzyme
Zinc oxide	A mineral ingredient of various pharmacological preparations to treat diaper dermatitis and other skin conditions, to protect the epidermis, and to prevent sunburn.	No drug targets
Zinc sulfate	A drug used to replenish low levels of zinc or prevent zinc deficiency, or to test for zinc deficiency.	No drug targets

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01306084	Viral Infections in Healthy and Immunocompromised Hosts	No drug interventions	Not Available	Not Available	recruiting
NCT01695187	NB-001 Treatment of Recurrent Herpes Labialis	NB-001	treatment	3	unknown_status
NCT01208298	Study to Evaluate Using a Cold Sore Patch to Treat Herpes Labialis	No drug interventions	Not Available	Not Available	completed
NCT00297011	Valacyclovir+Temovate Gel for the Treatment of Herpes Labialis	Clobetasol Valaciclovir	treatment	2	completed
NCT00306293	VALTREX(Valacyclovir) Once Daily for Viral Shedding In Subjects Newly Diagnosed With HSV-2	Valaciclovir	treatment	4	completed
NCT01653509	An Exploratory Study to Investigate the Inflammatory Response During a Cold Sore Episode	No drug interventions	treatment	1	completed
NCT00736437	Efficacy of Acyclovir in Combination With a Glucocorticosteroid on UV-Induced Herpes Labialis	No drug interventions	treatment	2	completed
NCT00375570	Safety Study of ME-609 for Treatment of Herpes Simplex Labialis in Adolescents	No drug interventions	treatment	3	completed
NCT01225341	Botulinum Toxin A for Herpes Labialis	Botulinum toxin type A	prevention	Not Available	terminated
NCT02582086	Study of a New Topical Natural Health Product for the Treatment of Herpes Labialis	No drug interventions	treatment	Not Available	unknown_status
NCT00711776	Bioequivalence Study of Aciclovir 5% Cream in Japanese Healthy Volunteers	No drug interventions	treatment	1	completed
NCT03310294	Immune Evidence to the Consumption of Lactobacillus GG and FOS Consumption in Patients With Herpes Labialis	No drug interventions	treatment	Not Available	completed
NCT02871492	Trial on Efficacy and Safety of Pritelivir Ointment for Treatment of Labial Herpes	Acyclovir Pritelivir	treatment	2	completed
NCT01484067	Study of a Cold Sore Patch for the Treatment of Herpes Labialis	No drug interventions	treatment	Not Available	completed
NCT00878072	Safety and Pharmacokinetics of Famciclovir Single 1500 mg Dose in Adolescents With Recurrent Herpes Labialis	Famciclovir	treatment	2 / 3	completed
NCT01574612	Open Label Safety Study of Xerese Cream in the Treatment of Recurrent Herpes Labialis in Children 6-11 Years Old	Acyclovir Hydrocortisone	treatment	3	completed
NCT02965781	Double-blind, Vehicle-controlled Study of the Efficacy and Safety of SADBE in Subjects With Recurrent Herpes Labialis	Squaric acid dibutyl ester	prevention	1 / 2	completed
NCT02207881	A Double-Blind, Randomized, Placebo-Controlled Study of Topical VDO for the Treatment of Herpes Simplex Labialis	No drug interventions	treatment	2	completed
NCT00769314	Phase 3 Clinical Study for the Treatment of Cold Sore	Acyclovir	treatment	3	completed
NCT03521479	A Phase 2, Muti-Center Study of Repeat Dosing of Squaric Acid Dibutyl Ester in Subjects With Herpes Labialis	Squaric acid dibutyl ester	prevention	2	terminated
NCT04539483	Monoclonal Antibody Therapy Against Chronic Herpes Simplex Virus 1 Infection	No drug interventions	treatment	2	terminated
NCT00735761	Study of ME-609 and Acyclovir for Treatment of Herpes Simplex Labialis in Immunocompromised Patients	Acyclovir	treatment	3	completed
NCT01971385	Safety and Efficacy of Squaric Acid Dibutyl Ester for the Treatment of Herpes Labialis	Squaric acid dibutyl ester	treatment	1	completed
NCT00469300	Iontophoretic Application of Acyclovir Gel to Treat Cold Sores	Acyclovir	treatment	2	completed
NCT02265913	Comparative Safety and Efficacy of Two Antiviral Treatments in the Treatment of Recurrent Herpes Simplex Labialis	Acyclovir	treatment	3	completed
NCT03661541	Immune Response and General Immune Health in Subjects Infected With Herpes Simplex Virus Type 1 (HSV-1)	Squaric acid dibutyl ester	screening	1	completed
NCT01257074	Non-inferiority Comparison of Efficacy and Safety of Penciclovir 10mg/g to Acyclovir 50mg/g in the Treatment of Recurrent Herpes Labialis	Acyclovir Penciclovir	treatment	3	completed
NCT02483182	Safety, Tolerability and Therapeutic Efficacy of Topical ZEP-3 Ointment (1.0%) for the Treatment of Cold Sores	Acyclovir	treatment	2	completed
NCT00913692	A Randomized Double-Blind Control-Comparison Crossover Trial of Oral Glutamine to Suppress Frequently Recurrent Herpes Labialis	Glycine L-Glutamine	prevention	2	terminated
NCT00230867	Iontophoretic Application of Acyclovir Cream to Treat Recurrent Herpes Labialis	No drug interventions	treatment	2	completed
NCT00453401	Safety, Pharmacokinetics, and Efficacy Study of NB-001 to Treat Recurrent Herpes Labialis	NB-001	treatment	2	completed
NCT03307772	Immune Response to the Consumption of Lactobacillus GG and FOS in Patients With Recurrent Herpes Labialis	No drug interventions	treatment	Not Available	completed
NCT00361881	Efficacy and Safety Study of ME-609 and Acyclovir for Treatment of Herpes Simplex Labialis	Acyclovir	prevention	3	completed