Herpes Simplex Infections (DBCOND0053830)

Identifiers

Synonyms

HSV Infection / Herpes Simplex Infection / Herpes Simplex Virus Infection / Herpesviral infection, unspecified / Herpes Simplex / Herpes simplex (disorder) / Herpesviral [herpes simplex] infections / Herpes simplex NOS

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Acyclovir	A guanosine analog used to treat herpes simplex, varicella zoster, herpes zoster.	DNA polymerase catalytic subunittarget DNA polymerase catalytic subunittarget Solute carrier family 22 member 1transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Ileal sodium/bile acid cotransportertransporter Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter Thymidine kinaseenzyme Guanylate kinaseenzyme Nucleoside diphosphokinaseenzyme Pyruvate Kinasesenzyme Creatine Kinasesenzyme Phosphoglycerate Kinasesenzyme Succinyl-CoA Synthetasesenzyme Phosphoenolpyruvate Carboxykinasesenzyme Adenylosuccinate Synthetasesenzyme Albumincarrier
Foscarnet	An antiviral used to treat CMV, HIV, and HSV infections.	DNA polymerase catalytic subunittarget DNA polymerase catalytic subunittarget Solute carrier family 22 member 6transporter Monocarboxylate transporter 1transporter
Imiquimod	A toll-like receptor 7 agonist used to treat non hyperkeratotic, non hypertrophic actinic keratosis, basal cell carcinoma, genital or perianal warts, and condyloma acuminata.	Toll-like receptor 7target Toll-like receptor 8target Cytochrome P450 3A4enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01026454	Valacyclovir vs. Acyclovir as HSV-2 Suppressive Therapy: Effect on Plasma HIV-1 Levels Among HIV-1/HSV-2 Co-infected Persons	Acyclovir Valaciclovir	treatment	4	completed
NCT06089252	Efficacy of Lazolex® Gel in the Treatment of Herpes Simplex	No drug interventions	treatment	2	completed
NCT05513625	Potential Influence of Esomeprazole on the Pharmacokinetics of Pritelivir	Esomeprazole Pritelivir	other	1	completed
NCT05671029	Thorough QT/QTc of Pritelivir in Healthy Subjects	No drug interventions	prevention	1	completed
NCT03073967	Trial on Efficacy and Safety of Pritelivir Tablets for Treatment of Acyclovir-resistant Mucocutaneous HSV (Herpes Simplex Virus) Infections in Immunocompromised Subjects	Cidofovir Foscarnet Imiquimod Pritelivir	treatment	3	recruiting
NCT05331417	Bronchoscopic Score for Prediction of Herpes Simplex-virus Type 1 (HSV-1) Reactivation	No drug interventions	Not Available	Not Available	recruiting
NCT00057330	HerpeVac Trial for Young Women	Hepatitis A Vaccine Monophosphoryl lipid A	prevention	3	completed
NCT02579083	Safety Study of Monoclonal Antibodies to Reduce the Vaginal Transmission of HSV and HIV	No drug interventions	treatment	1	completed
NCT02715752	A Retrospective Chart Review Study of Gene-Eden-VIR/Novirin	No drug interventions	Not Available	Not Available	completed
NCT02270099	Evaluation of the HSV 1 & 2 Assay in Specimens From Symptomatic Subjects	No drug interventions	Not Available	Not Available	completed
NCT01429311	Interferon Responses in Eczema Herpeticum	No drug interventions	Not Available	Not Available	completed
NCT01689285	Bioequivalence Study in Healthy Volunteers of a New Paediatric Formulation of Valacyclovir	Valaciclovir	other	1	completed
NCT05226949	Host RNA Expression Profiles and Protein Biomarkers in Neonatal Herpes Simplex Virus Infection	No drug interventions	Not Available	Not Available	completed
NCT04294030	NOWDx Test for the Diagnosis of Herpes Simplex Virus Type 2	No drug interventions	Not Available	Not Available	withdrawn
NCT04560790	Safety and Efficacy of CRISPR/Cas9 mRNA Instantaneous Gene Editing Therapy to Treat Refractory Viral Keratitis	BD-111	treatment	Not Available	completed
NCT01682109	Palatability Testing of a New Paediatric Formulation of Valacyclovir	Valaciclovir	other	4	completed
NCT02346760	Study to Evaluate Safety, Tolerability, and Pharmacokinetics of UB-621 in Healthy Volunteers	No drug interventions	other	1	completed
NCT04081480	Pharmacokinetics of Valacyclovir Oral Solution in Children	Valaciclovir	other	Not Available	terminated
NCT04713423	Oral and Perioral Herpes Simplex Virus Infection Type I in a Five-month-old Infant: A Case Report	No drug interventions	Not Available	Not Available	completed