Nicotinic Acids

Name
Nicotinic Acids
Accession Number
DBCAT000824
Description

2-, 3-, or 4-Pyridinecarboxylic acids. Pyridine derivatives substituted with a carboxy group at the 2-, 3-, or 4-position. The 3-carboxy derivative (NIACIN) is active as a vitamin.

Drugs
DrugDrug Description
ArecolineAn alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the...
AsciminibAn inhibitor of ABL/BCR-ABL1 tyrosine kinase for the treatment of patients with Philadelphia chromosome-positive CML, including those with the T315I mutation.
AZD-4017AZD-4017 is under investigation in clinical trial NCT01173471 (A Phase IIa Study to Assess the Tolerability, Safety, and Efficacy of AZD4017 for Raised Intra-ocular Pressure).
BoscalidBoscalid has been investigated for the treatment of OSDI, Glaucoma, Staining, Schirmers, and Disease Severity, among others.
Chromium nicotinateA medication used to treat chromium deficiencies and associated symptoms and also in total parenteral nutrition.
ClonixinAn NSAID used to relieve pain associated with arthritis, migraines, and various soft tissue disorders.
EtazolateInvestigated for use/treatment in alzheimer's disease and neurologic disorders.
FlunixinFlunixin is a non-steroidal anti-inflammatory drug for use in pigs, cattle and horses. It exerts analgesic and antipyretic effects. This drug is often prepared for use in meglumine salt form....
GDC-0623GDC-0623 has been used in trials studying the treatment of Solid Cancers.
GlunicateGlunicate is a small molecule drug. Glunicate has a monoisotopic molecular weight of 704.19 Da.
GSK-189254Not Annotated
LevamlodipineA calcium channel blocker used to treat hypertension.
MerestinibMerestinib has been used in trials studying the treatment of Cancer, Solid Tumor, Advanced cancer, ColoRectal Cancer, and Metastatic Cancer, among others.
Methyl nicotinateA methyl ester of niacin used to treat muscle and joint pain.
MK-0668Not Annotated
MorniflumateAn NSAID derived from niflumic acid used in the symptomatic treatment of inflammatory conditions of the airways, ENT, and the urogenital and osteoarticular systems.
MotesanibInvestigated for use/treatment in solid tumors.
N-methylnicotinamideN-methylnicotinamide is an experimental drug with no approved indication.
NiacinA B vitamin used to treat hypertriglyceridemia and pellagra.
NiaprazineNiaprazine is a selective brain catecholamine depletor.
NicaravenInvestigated for use/treatment in cerebrovascular disease (unspecified).
NiceritrolNot Annotated
NicofuranoseNot Annotated
NicorandilA vasodilatory drug that functions through potassium channels and intracellular cGMP concentrations commonly used to treat angina.
NicotinamideAn ingredient found in a variety of cosmetic products.
Nicotinamide ribosideNicotinamide riboside is under investigation in clinical trial NCT03432871 (Nicotinamide Riboside and Mitochondrial Biogenesis).
NicoxamatNicoxamat is a small molecule drug. Nicoxamat has a monoisotopic molecular weight of 138.04 Da.
NifenazoneNot Annotated
Niflumic acidA cyclooxygenase-2 inhibitor used to alleviate inflammation, pain, and edema associated with acute and chronic inflammatory conditions, such as rheumatoid arthritis, osteoarthritis, post-operative inflammatory conditions, and physical trauma.
NikethamideA nicotinic acid derivative indicated as a respiratory stimulant.
NimodipineA calcium channel blocker used to improve neurological outcomes in patients with subarachnoid hemorrhage due to a ruptured intracranial aneurysm.
OndelopranOndelopran has been used in trials studying the treatment of Alcohol Dependence.
PeficitinibPeficitinib has been used in trials studying the treatment and basic science of Psoriasis, Pharmacodynamics, Drug Interactions, Colitis, Ulcerative, and RHEUMATOID ARTHRITIS, among others.
PicafibratePicafibrate is a small molecule drug. The usage of the INN stem '-fibrate' in the name indicates that Picafibrate is a clofibrate derivative, peroxisome proliferator activated receptor-a (PPAR-a) agonist. Picafibrate...
PimasertibPimasertib is under investigation in clinical trial NCT01378377 (Combination Trial of Pimasertib (MSC1936369B) With Temsirolimus).
Pipemidic acidA quinolone antibiotic indicated in the treatment of susceptible urinary tract infections.
Piromidic acidNot Annotated
RamixotidineRamixotidine is a small molecule drug. The usage of the INN stem '-tidine' in the name indicates that Ramixotidine is a histamine- H2​-receptor antagonist, cimetidine derivative. Ramixotidine has a monoisotopic...
SorafenibA kinase inhibitor used to treat unresectable liver carcinoma, advanced renal carcinoma, and differentiated thyroid carcinoma.
TovecimigNOV1501 is a biologic drug. NOV1501 is under investigation in clinical trial NCT03292783 (This is a Study to Evaluate the Safety and Tolerability of the Study Drug ABL001, and to...
TrigonellamideTrigonellamide is under investigation in clinical trial NCT01930240 (The Safety of a Hypolipidemic Agent in Healthy Normal Volunteers).
XanthinolA vasodilatory niacin found in diet supplements.
Drugs & Drug Targets
DrugTargetType
ArecolineMuscarinic acetylcholine receptor M3target
ArecolineMuscarinic acetylcholine receptor M1target
AsciminibCytochrome P450 2C9enzyme
AsciminibSolute carrier family 22 member 1transporter
AsciminibSolute carrier organic anion transporter family member 1B3transporter
AsciminibSolute carrier organic anion transporter family member 1B1transporter
AsciminibATP-dependent translocase ABCB1transporter
AsciminibCytochrome P450 2C19enzyme
AsciminibUDP-glucuronosyltransferase 1A1enzyme
AsciminibBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
AsciminibTyrosine-protein kinase ABL1target
AsciminibUDP-glucuronosyltransferase 2B17enzyme
AsciminibUDP-glucuronosyltransferase 2B7enzyme
AsciminibCytochrome P450 3A4enzyme
AZD-401711-beta-hydroxysteroid dehydrogenase 1target
BoscalidSuccinate dehydrogenasetarget
Chromium nicotinateCytochrome b5target
Chromium nicotinateSerotransferrincarrier
ClonixinProstaglandin G/H synthase 1target
ClonixinProstaglandin G/H synthase 2target
EtazolateGamma-aminobutyric acid receptor subunit beta-3target
EtazolateGamma-aminobutyric acid receptor subunit gamma-3target
FlunixinProstaglandin G/H synthase 1target
FlunixinHuman Cyclooxygenasestarget
FlunixinPolyunsaturated fatty acid lipoxygenase ALOX15target
FlunixinProstaglandin G/H synthase 2target
GDC-0623Cytochrome P450 2C19enzyme
GDC-0623Cytochrome P450 2C9enzyme
GDC-0623Dual specificity mitogen-activated protein kinase kinase 2target
GDC-0623Dual specificity mitogen-activated protein kinase kinase 1target
GSK-189254Histamine H3 receptortarget
LevamlodipineNitric oxide synthase 3target
LevamlodipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
LevamlodipineCytochrome P450 3A4enzyme
LevamlodipineNitric oxide synthase, inducibletarget
LevamlodipineVoltage gated L-type calcium channeltarget
LevamlodipineOrganic cation/carnitine transporter 2transporter
LevamlodipineIleal sodium/bile acid cotransportertransporter
LevamlodipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
LevamlodipineATP-dependent translocase ABCB1transporter
LevamlodipineAlbumincarrier
LevamlodipineNitric oxide synthase 3enzyme
LevamlodipineNitric oxide synthase, inducibleenzyme
MerestinibHepatocyte growth factor receptortarget
MK-0668Integrin alpha-4target
MK-0668Integrin beta-1target
MK-0668VLA-4 (very late antigen-4)target
MorniflumatePolyunsaturated fatty acid 5-lipoxygenasetarget
MorniflumateProstaglandin G/H synthase 1target
MorniflumateProstaglandin G/H synthase 2target
MorniflumatePolyunsaturated fatty acid 5-lipoxygenaseenzyme
MorniflumateProstaglandin G/H synthase 2enzyme
MorniflumateLeukotriene B4 receptor 1target
MorniflumateThromboxane A2 receptortarget
MorniflumateUDP-glucuronosyltransferase 1A9enzyme
MotesanibVascular endothelial growth factor receptortarget
MotesanibProto-oncogene tyrosine-protein kinase receptor Rettarget
MotesanibMast/stem cell growth factor receptor Kittarget
MotesanibVascular endothelial growth factor receptor 2target
N-methylnicotinamideNon-receptor tyrosine-protein kinase TYK2target
N-methylnicotinamideNicotinamide N-methyltransferaseenzyme
N-methylnicotinamideAldehyde oxidaseenzyme
N-methylnicotinamideMultidrug and toxin extrusion protein 2transporter
N-methylnicotinamideMultidrug and toxin extrusion protein 1transporter
N-methylnicotinamideSolute carrier family 22 member 2transporter
NiacinHydroxycarboxylic acid receptor 2target
NiacinDiacylglycerol O-acyltransferase 2target
NiacinNicotinamide N-methyltransferasetarget
NiacinCytochrome P450 2E1enzyme
NiacinNicotinate-nucleotide pyrophosphorylase [carboxylating]target
NiacinHydroxycarboxylic acid receptor 3target
NiacinOrganic cation/carnitine transporter 2transporter
NiacinSolute carrier organic anion transporter family member 2B1transporter
NiacinMonocarboxylate transporter 1transporter
NiacinCytochrome P450 2D6enzyme
NiacinSodium-coupled monocarboxylate transporter 1transporter
NiacinCytochrome P450 3A4enzyme
NiacinMonocarboxylate transporter 4transporter
NiacinThyroxine-binding globulincarrier
NiaprazineHistamine H1 receptortarget
NiaprazineAlpha-1 adrenergic receptorstarget
Niaprazine5-hydroxytryptamine 2 receptortarget
NicaravenPoly [ADP-ribose] polymerase 1target
NicorandilATP-binding cassette sub-family C member 9target
NicotinamideCytochrome P450 3A4enzyme
NicotinamideCytochrome P450 2E1enzyme
NicotinamideCytochrome P450 2D6enzyme
NicotinamidePoly [ADP-ribose] polymerase 1target
NicotinamideL-lactate dehydrogenase A chaintarget
NicotinamideExotoxin Atarget
NicotinamideADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2target
NicotinamideNAD-dependent protein deacylase sirtuin-5, mitochondrialtarget
Nicotinamide ribosideNicotinamide riboside kinase 1target
Nicotinamide ribosideNicotinamide riboside kinase 2target
Nicotinamide ribosidePurine nucleoside phosphorylaseenzyme
NicoxamatTyrosinasetarget
Niflumic acidChloride channel protein ClC-Katarget
Niflumic acidPhospholipase A2target
Niflumic acidUDP-glucuronosyltransferase 1A9enzyme
Niflumic acidUDP-glucuronosyltransferase 1A9target
Niflumic acidCytosolic phospholipase A2target
Niflumic acidProstaglandin G/H synthase 1target
Niflumic acidProstaglandin G/H synthase 2target
Niflumic acidMonocarboxylate transporter 1transporter
Niflumic acidMonocarboxylate transporter 2transporter
NikethamideCytochrome P450 1A Subfamilytarget
NikethamideNeuronal Acetylcholine (nACh) Receptor Subunitstarget
NimodipineCytochrome P450 3A4enzyme
NimodipineMineralocorticoid receptortarget
NimodipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
NimodipineVoltage-dependent L-type calcium channel subunit alpha-1Starget
NimodipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
NimodipineVoltage-dependent L-type calcium channel subunit beta-2target
NimodipineVoltage-dependent L-type calcium channel subunit alpha-1Ftarget
NimodipineVoltage-dependent L-type calcium channel subunit beta-1target
NimodipineVoltage-dependent L-type calcium channel subunit beta-3target
NimodipineVoltage-dependent L-type calcium channel subunit beta-4target
NimodipineAryl hydrocarbon receptortarget
NimodipineVoltage gated L-type calcium channeltarget
OndelopranMu-type opioid receptortarget
PeficitinibJanus (JAK) kinasestarget
PeficitinibTyrosine-protein kinase JAK1target
PeficitinibTyrosine-protein kinase JAK3target
PimasertibDual specificity mitogen-activated protein kinase kinase 2target
PimasertibDual specificity mitogen-activated protein kinase kinase 1target
PimasertibMitogen-activated protein kinase kinase (MAPKK)target
Pipemidic acidDNA gyrase subunit Btarget
Pipemidic acidDNA gyrase subunit Atarget
Pipemidic acidCytochrome P450 1A2enzyme
Pipemidic acidDNA topoisomerase 4 subunit Atarget
Pipemidic acidDNA topoisomerase 4 subunit Btarget
RamixotidineHistamine H2 receptortarget
SorafenibMast/stem cell growth factor receptor Kittarget
SorafenibPlatelet-derived growth factor receptor betatarget
SorafenibVascular endothelial growth factor receptor 2target
SorafenibCytochrome P450 3A4enzyme
SorafenibUDP-glucuronosyltransferase 1A9enzyme
SorafenibVascular endothelial growth factor receptor 3target
SorafenibRAF proto-oncogene serine/threonine-protein kinasetarget
SorafenibReceptor-type tyrosine-protein kinase FLT3target
SorafenibCytochrome P450 2B6enzyme
SorafenibCytochrome P450 2C8enzyme
SorafenibCytochrome P450 3A5enzyme
SorafenibVascular endothelial growth factor receptortarget
SorafenibSerine/threonine-protein kinase B-raftarget
SorafenibCytochrome P450 3A7enzyme
SorafenibCytochrome P450 2C9enzyme
SorafenibATP-binding cassette sub-family C member 4transporter
SorafenibATP-dependent translocase ABCB1transporter
SorafenibATP-binding cassette sub-family C member 2transporter
SorafenibBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
SorafenibCytochrome P450 1A2enzyme
SorafenibCytochrome P450 2C19enzyme
SorafenibCytochrome P450 2D6enzyme
SorafenibUDP-glucuronosyltransferase 1A1enzyme
SorafenibRalA-binding protein 1transporter
SorafenibFibroblast growth factor receptor 1target
SorafenibProto-oncogene tyrosine-protein kinase receptor Rettarget
SorafenibVascular endothelial growth factor receptor 1target
SorafenibSolute carrier organic anion transporter family member 1B1transporter
SorafenibEpidermal growth factor receptortarget
TovecimigVascular endothelial growth factor A, long formtarget
TovecimigDelta-like protein 4target
TrigonellamideNicotinamide N-methyltransferasetarget
TrigonellamideNicotinamide N-methyltransferaseenzyme
Xanthinol2-oxoglutarate dehydrogenase complex component E1target
XanthinolIsocitrate dehydrogenase [NAD] subunit alpha, mitochondrialtarget
XanthinolGlyceraldehyde-3-phosphate dehydrogenasetarget
XanthinolNAD(P) transhydrogenase, mitochondrialtarget
XanthinolMalate dehydrogenase, mitochondrialtarget
XanthinolLarge ribosomal subunit protein uL3target