Nicotinic Acids

Name
Nicotinic Acids
Accession Number
DBCAT000824
Description

2-, 3-, or 4-Pyridinecarboxylic acids. Pyridine derivatives substituted with a carboxy group at the 2-, 3-, or 4-position. The 3-carboxy derivative (NIACIN) is active as a vitamin.

Drugs
DrugDrug Description
NiacinA B vitamin used to treat hypertriglyceridemia and pellagra.
NimodipineA calcium channel blocker used to improve neurological outcomes in patients with subarachnoid hemorrhage due to a ruptured intracranial aneurysm.
SorafenibA kinase inhibitor used in the treatment of unresectable liver carcinoma and advanced renal carcinoma.
NicotinamideAn ingredient found in a variety of cosmetic products.
ArecolineAn alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the...
Niflumic acidUsed in the treatment of rheumatoid arthritis.
MotesanibInvestigated for use/treatment in solid tumors.
NicaravenInvestigated for use/treatment in cerebrovascular disease (unspecified).
N-methylnicotinamideN-methylnicotinamide is an experimental drug with no approved indication.
XanthinolA vasodilatory niacin found in diet supplements.
ClonixinIndicated for use in the management of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation.
NicorandilIndicated for the prevention and treatment of chronic stable angina pectoris and reduction in the risk of acute coronary syndromes.
LevamlodipineA calcium channel blocker used to treat hypertension.
MorniflumateMorniflumate is indicated for the treatment of inflammatory conditions affecting the airways, ENT system, urogenital tract and bone and joint systems in adults. In Italy, morniflumate is also indicated for...
FlunixinFlunixin is a non-steroidal anti-inflammatory drug for use in pigs, cattle and horses. It exerts analgesic and antipyretic effects. This drug is often prepared for use in meglumine salt form....
PeficitinibPeficitinib has been used in trials studying the treatment and basic science of Psoriasis, Pharmacodynamics, Drug Interactions, Colitis, Ulcerative, and RHEUMATOID ARTHRITIS, among others.
MerestinibMerestinib has been used in trials studying the treatment of Cancer, Solid Tumor, Advanced cancer, ColoRectal Cancer, and Metastatic Cancer, among others.
OndelopranOndelopran has been used in trials studying the treatment of Alcohol Dependence.
BoscalidBoscalid has been investigated for the treatment of OSDI, Glaucoma, Staining, Schirmers, and Disease Severity, among others.
NifenazoneNot Annotated
NicofuranoseNot Annotated
NiceritrolNot Annotated
NikethamideNot Annotated
NiaprazineNiaprazine is a selective brain catecholamine depletor.
Piromidic acidNot Annotated
Pipemidic acidNot Annotated
Methyl nicotinateA methyl ester of niacin used to treat muscle and joint pain.
Chromium nicotinateA medication used to treat chromium deficiencies and associated symptoms and also in total parenteral nutrition.
AZD-4017AZD-4017 is under investigation in clinical trial NCT01173471 (A Phase IIa Study to Assess the Tolerability, Safety, and Efficacy of AZD4017 for Raised Intra-ocular Pressure).
PimasertibPimasertib is under investigation in clinical trial NCT01378377 (Combination Trial of Pimasertib (MSC1936369B) With Temsirolimus).
Nicotinamide ribosideNicotinamide riboside is under investigation in clinical trial NCT03432871 (Nicotinamide Riboside and Mitochondrial Biogenesis).
TrigonellamideTrigonellamide is under investigation in clinical trial NCT01930240 (The Safety of a Hypolipidemic Agent in Healthy Normal Volunteers).
GDC-0623GDC-0623 has been used in trials studying the treatment of Solid Cancers.
ABL-001ABL001 has been used in trials studying the health services research of Chronic Myelogenous Leukemia and Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia.
MK-0668Not Annotated
Drugs & Drug Targets
DrugTargetType
NiacinHydroxycarboxylic acid receptor 2target
NiacinNicotinamide N-methyltransferasetarget
NiacinNicotinate-nucleotide pyrophosphorylase [carboxylating]target
NiacinHydroxycarboxylic acid receptor 3target
NiacinSolute carrier family 22 member 5transporter
NiacinSolute carrier organic anion transporter family member 2B1transporter
NiacinMonocarboxylate transporter 1transporter
NiacinCytochrome P450 2D6enzyme
NiacinSodium-coupled monocarboxylate transporter 1transporter
NiacinMonocarboxylate transporter 4transporter
NiacinThyroxine-binding globulincarrier
NiacinCytochrome P450 3A4enzyme
NiacinCytochrome P450 2E1enzyme
NimodipineCytochrome P450 3A4enzyme
NimodipineMineralocorticoid receptortarget
NimodipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
NimodipineVoltage-dependent L-type calcium channel subunit alpha-1Starget
NimodipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
NimodipineVoltage-dependent L-type calcium channel subunit beta-2target
NimodipineVoltage-dependent L-type calcium channel subunit alpha-1Ftarget
NimodipineVoltage-dependent L-type calcium channel subunit beta-1target
NimodipineVoltage-dependent L-type calcium channel subunit beta-3target
NimodipineVoltage-dependent L-type calcium channel subunit beta-4target
NimodipineAryl hydrocarbon receptortarget
SorafenibSerine/threonine-protein kinase B-raftarget
SorafenibReceptor-type tyrosine-protein kinase FLT3target
SorafenibRAF proto-oncogene serine/threonine-protein kinasetarget
SorafenibVascular endothelial growth factor receptor 3target
SorafenibPlatelet-derived growth factor receptor betatarget
SorafenibMast/stem cell growth factor receptor Kittarget
SorafenibVascular endothelial growth factor receptor 2target
SorafenibCytochrome P450 3A4enzyme
SorafenibUDP-glucuronosyltransferase 1-9enzyme
SorafenibCytochrome P450 2B6enzyme
SorafenibCytochrome P450 2C8enzyme
SorafenibCytochrome P450 3A5enzyme
SorafenibCytochrome P450 3A7enzyme
SorafenibCytochrome P450 2C9enzyme
SorafenibMultidrug resistance-associated protein 4transporter
SorafenibP-glycoprotein 1transporter
SorafenibCanalicular multispecific organic anion transporter 1transporter
SorafenibATP-binding cassette sub-family G member 2transporter
SorafenibCytochrome P450 1A2enzyme
SorafenibCytochrome P450 2C19enzyme
SorafenibCytochrome P450 2D6enzyme
SorafenibUDP-glucuronosyltransferase 1-1enzyme
SorafenibRalA-binding protein 1transporter
SorafenibFibroblast growth factor receptor 1target
SorafenibProto-oncogene tyrosine-protein kinase receptor Rettarget
SorafenibVascular endothelial growth factor receptor 1target
SorafenibSolute carrier organic anion transporter family member 1B1transporter
NicotinamideNAD-dependent protein deacylase sirtuin-5, mitochondrialtarget
NicotinamideADP-ribosyl cyclase 2target
NicotinamideExotoxin Atarget
NicotinamideL-lactate dehydrogenase A chaintarget
NicotinamidePoly [ADP-ribose] polymerase 1target
NicotinamideCytochrome P450 2D6enzyme
NicotinamideCytochrome P450 2E1enzyme
NicotinamideCytochrome P450 3A4enzyme
ArecolineMuscarinic acetylcholine receptor M1target
ArecolineMuscarinic acetylcholine receptor M3target
Niflumic acidPhospholipase A2target
Niflumic acidChloride channel protein ClC-Katarget
Niflumic acidMonocarboxylate transporter 2transporter
Niflumic acidMonocarboxylate transporter 1transporter
Niflumic acidProstaglandin G/H synthase 2target
Niflumic acidProstaglandin G/H synthase 1target
Niflumic acidCytosolic phospholipase A2target
Niflumic acidUDP-glucuronosyltransferase 1-9target
Niflumic acidUDP-glucuronosyltransferase 1-9enzyme
N-methylnicotinamideSolute carrier family 22 member 2transporter
N-methylnicotinamideMultidrug and toxin extrusion protein 1transporter
N-methylnicotinamideMultidrug and toxin extrusion protein 2transporter
N-methylnicotinamideAldehyde oxidaseenzyme
Xanthinol60S ribosomal protein L3target
XanthinolNAD(P) transhydrogenase, mitochondrialtarget
XanthinolGlyceraldehyde-3-phosphate dehydrogenasetarget
XanthinolIsocitrate dehydrogenase [NAD] subunit alpha, mitochondrialtarget
Xanthinol2-oxoglutarate dehydrogenase, mitochondrialtarget
XanthinolMalate dehydrogenase, mitochondrialtarget
NicorandilATP-binding cassette sub-family C member 9target
LevamlodipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
LevamlodipineCytochrome P450 3A4enzyme
LevamlodipineNitric oxide synthase, endothelialtarget
LevamlodipineNitric oxide synthase, inducibletarget
LevamlodipineNitric oxide synthase, inducibleenzyme
LevamlodipineNitric oxide synthase, endothelialenzyme
LevamlodipineSerum albumincarrier
LevamlodipineP-glycoprotein 1transporter
LevamlodipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
LevamlodipineIleal sodium/bile acid cotransportertransporter
LevamlodipineSolute carrier family 22 member 5transporter
MorniflumateArachidonate 5-lipoxygenasetarget
MorniflumateProstaglandin G/H synthase 2target
MorniflumateArachidonate 5-lipoxygenaseenzyme
MorniflumateProstaglandin G/H synthase 2enzyme
MorniflumateLeukotriene B4 receptor 1target
MorniflumateThromboxane A2 receptortarget
MorniflumateUDP-glucuronosyltransferase 1-9enzyme
Pipemidic acidCytochrome P450 1A2enzyme
Chromium nicotinateSerotransferrincarrier
Chromium nicotinateCytochrome b5target
MK-0668VLA-4 (very late antigen-4)target