This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Idazoxan
- DrugBank Accession Number
- DB12551
- Background
Idazoxan has been used in trials studying the basic science of Molecular Imaging, Alzheimer Disease, and Major Depressive Disorder.
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Idazoxan (DB12551)
- Weight
- Average: 204.229
Monoisotopic: 204.089877634 - Chemical Formula
- C11H12N2O2
- Synonyms
- Idazoxan
- idazoxano
Pharmacology
- Indication
Not Available
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Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcebutolol Idazoxan may decrease the antihypertensive activities of Acebutolol. Aceclofenac The risk or severity of hypertension can be increased when Aceclofenac is combined with Idazoxan. Acemetacin The risk or severity of hypertension can be increased when Idazoxan is combined with Acemetacin. Acetylsalicylic acid The risk or severity of hypertension can be increased when Acetylsalicylic acid is combined with Idazoxan. Alclofenac The risk or severity of hypertension can be increased when Idazoxan is combined with Alclofenac. Alfentanil The risk or severity of hypertension can be increased when Alfentanil is combined with Idazoxan. Alfuzosin Idazoxan may increase the hypotensive activities of Alfuzosin. Aliskiren Idazoxan may decrease the antihypertensive activities of Aliskiren. Almotriptan The risk or severity of hypertension can be increased when Almotriptan is combined with Idazoxan. Ambrisentan Idazoxan may decrease the antihypertensive activities of Ambrisentan. 
Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- Not Available
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as benzo-1,4-dioxanes. These are heterocyclic compounds containing a benzene ring fused to a 1,4-dioxane ring.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Benzodioxanes
- Sub Class
- Benzo-1,4-dioxanes
- Direct Parent
- Benzo-1,4-dioxanes
- Alternative Parents
- Alkyl aryl ethers / Para dioxins / Imidolactams / Benzenoids / Imidazolines / Propargyl-type 1,3-dipolar organic compounds / Oxacyclic compounds / Carboximidamides / Carboxamidines / Azacyclic compounds show 2 more
- Substituents
- 2-imidazoline / Alkyl aryl ether / Amidine / Aromatic heteropolycyclic compound / Azacycle / Benzenoid / Benzo-1,4-dioxane / Carboximidamide / Carboxylic acid amidine / Ether show 11 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- ring assembly, benzodioxine, imidazolines (CHEBI:5862)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- Y310PA316B
- CAS number
- 79944-58-4
- InChI Key
- HPMRFMKYPGXPEP-UHFFFAOYSA-N
- InChI
- InChI=1S/C11H12N2O2/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11/h1-4,10H,5-7H2,(H,12,13)
- IUPAC Name
- 2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole
- SMILES
- C1CN=C(N1)C1COC2=CC=CC=C2O1
References
- General References
- Not Available
- External Links
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Withdrawn Not Available Major Depressive Disorder (MDD) 1 0 Completed Basic Science Alzheimer's Disease (AD) / Healthy Subjects (HS) / Molecular Imaging 1 0 Terminated Basic Science Alzheimer's Disease (AD) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 1.37 mg/mL ALOGPS logP 1.01 ALOGPS logP 0.77 Chemaxon logS -2.2 ALOGPS pKa (Strongest Basic) 8.62 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 42.85 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 54.55 m3·mol-1 Chemaxon Polarizability 21.08 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Drug created at October 20, 2016 22:49 / Updated at February 21, 2021 18:53