Ondelopran

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Ondelopran
DrugBank Accession Number
DB12585
Background

Ondelopran has been used in trials studying the treatment of Alcohol Dependence.

Type
Small Molecule
Groups
Investigational
Structure
Thumb
Weight
Average: 373.428
Monoisotopic: 373.180169808
Chemical Formula
C20H24FN3O3
Synonyms
  • Ondelopran
External IDs
  • LY-2196044
  • LY2196044

Pharmacology

Indication

Not Available

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Medicalerrors
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AlfentanilThe therapeutic efficacy of Alfentanil can be decreased when used in combination with Ondelopran.
BenzhydrocodoneThe therapeutic efficacy of Benzhydrocodone can be decreased when used in combination with Ondelopran.
BuprenorphineThe therapeutic efficacy of Buprenorphine can be decreased when used in combination with Ondelopran.
ButorphanolThe therapeutic efficacy of Butorphanol can be decreased when used in combination with Ondelopran.
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Ondelopran.
DextropropoxypheneThe therapeutic efficacy of Dextropropoxyphene can be decreased when used in combination with Ondelopran.
DezocineThe therapeutic efficacy of Dezocine can be decreased when used in combination with Ondelopran.
DiamorphineThe therapeutic efficacy of Diamorphine can be decreased when used in combination with Ondelopran.
DihydrocodeineThe therapeutic efficacy of Dihydrocodeine can be decreased when used in combination with Ondelopran.
DiphenoxylateThe therapeutic efficacy of Diphenoxylate can be decreased when used in combination with Ondelopran.
Interactions
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Food Interactions
Not Available

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as diarylethers. These are organic compounds containing the dialkyl ether functional group, with the formula ROR', where R and R' are aryl groups.
Kingdom
Organic compounds
Super Class
Organic oxygen compounds
Class
Organooxygen compounds
Sub Class
Ethers
Direct Parent
Diarylethers
Alternative Parents
Nicotinamides / Phenylmethylamines / Phenoxy compounds / Phenol ethers / Benzylamines / Aralkylamines / Fluorobenzenes / Oxanes / Aryl fluorides / Heteroaromatic compounds
show 9 more
Substituents
Amine / Amino acid or derivatives / Aralkylamine / Aromatic heteromonocyclic compound / Aryl fluoride / Aryl halide / Azacycle / Benzenoid / Benzylamine / Carboxamide group
show 26 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
4VZT670SD9
CAS number
676501-25-0
InChI Key
QWNDOCKIKKQJNN-UHFFFAOYSA-N
InChI
InChI=1S/C20H24FN3O3/c21-17-11-15(12-23-8-5-14-6-9-26-10-7-14)1-3-18(17)27-19-4-2-16(13-24-19)20(22)25/h1-4,11,13-14,23H,5-10,12H2,(H2,22,25)
IUPAC Name
6-[2-fluoro-4-({[2-(oxan-4-yl)ethyl]amino}methyl)phenoxy]pyridine-3-carboxamide
SMILES
NC(=O)C1=CC=C(OC2=C(F)C=C(CNCCC3CCOCC3)C=C2)N=C1

References

General References
Not Available
PubChem Compound
10457387
PubChem Substance
347828805
ChemSpider
8632801
ChEMBL
CHEMBL2103878
ZINC
ZINC000038910715

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedTreatmentAlcohol Dependency1
2CompletedTreatmentAlcohol Dependency1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00461 mg/mLALOGPS
logP3.08ALOGPS
logP2.19ChemAxon
logS-4.9ALOGPS
pKa (Strongest Acidic)13.46ChemAxon
pKa (Strongest Basic)9.27ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area86.47 Å2ChemAxon
Rotatable Bond Count8ChemAxon
Refractivity100.97 m3·mol-1ChemAxon
Polarizability38.1 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Drug created on October 20, 2016 23:02 / Updated on February 21, 2021 18:53