Nomegestrol acetate
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Name
- Nomegestrol acetate
- Accession Number
- DB13981
- Description
Nomegestrol acetate, also known as NOMAC, is a progestin used in oral contraceptives, menopausal hormone therapy, and for the treatment of gynecological disorders.
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Nomegestrol acetate (DB13981)
- Weight
- Average: 370.489
Monoisotopic: 370.214409446 - Chemical Formula
- C23H30O4
- Synonyms
- 17-alpha-Acetoxy-6-methyl-19-nor-4,6-pregnadiene-3,20-dione
- 17-alpha-Hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione acetate
- External IDs
- ORG 10486-0
- ORG-10486-0
- TX 066
- TX-066
Pharmacology
- Indication
- Not Available
- Associated Conditions
- Associated Therapies
- Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
Learn More- Pharmacodynamics
- Not Available
- Mechanism of action
- Not Available
- Absorption
- Not Available
- Volume of distribution
- Not Available
- Protein binding
- Not Available
- Metabolism
- Not Available
- Route of elimination
- Not Available
- Half-life
- Not Available
- Clearance
- Not Available
- Adverse Effects
Learn about our commercial Adverse Effects data.
Learn More- Toxicity
- Not Available
- Affected organisms
- Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Unlock Additional DataAbametapir The serum concentration of Nomegestrol acetate can be increased when it is combined with Abametapir. Abciximab Nomegestrol acetate may decrease the anticoagulant activities of Abciximab. Acenocoumarol The therapeutic efficacy of Acenocoumarol can be decreased when used in combination with Nomegestrol acetate. Acetaminophen The metabolism of Nomegestrol acetate can be increased when combined with Acetaminophen. Acetazolamide The metabolism of Nomegestrol acetate can be increased when combined with Acetazolamide. Acetohexamide The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Nomegestrol acetate. Acetylsalicylic acid Nomegestrol acetate may decrease the anticoagulant activities of Acetylsalicylic acid. Acitretin The therapeutic efficacy of Nomegestrol acetate can be decreased when used in combination with Acitretin. Alitretinoin The therapeutic efficacy of Nomegestrol acetate can be decreased when used in combination with Alitretinoin. Alpelisib The metabolism of Nomegestrol acetate can be increased when combined with Alpelisib. Additional Data Available- Extended DescriptionExtended DescriptionAvailable for Purchase
Extended description of the mechanism of action and particular properties of each drug interaction.
Learn more - SeveritySeverityAvailable for Purchase
A severity rating for each drug interaction, from minor to major.
Learn more - Evidence LevelEvidence LevelAvailable for Purchase
A rating for the strength of the evidence supporting each drug interaction.
Learn more - ActionActionAvailable for Purchase
An effect category for each drug interaction. Know how this interaction affects the subject drug.
Learn more
- Food Interactions
- Not Available
Products
Categories
- Drug Categories
- Adrenal Cortex Hormones
- Antineoplastic Agents, Hormonal
- Combination Contraceptives (with Estrogen and derivatives)
- Contraceptive Agents, Female
- Contraceptives, Oral
- Cytochrome P-450 CYP3A Substrates
- Cytochrome P-450 CYP3A4 Substrates
- Cytochrome P-450 Substrates
- Fused-Ring Compounds
- Hormonal Contraceptives for Systemic Use
- Norpregnanes
- Norsteroids
- Pregnadienes
- Pregnanes
- Progesterone Congeners
- Progestin Contraceptives
- Progestins
- Steroids
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as gluco/mineralocorticoids, progestogins and derivatives. These are steroids with a structure based on a hydroxylated prostane moiety.
- Kingdom
- Organic compounds
- Super Class
- Lipids and lipid-like molecules
- Class
- Steroids and steroid derivatives
- Sub Class
- Pregnane steroids
- Direct Parent
- Gluco/mineralocorticoids, progestogins and derivatives
- Alternative Parents
- Steroid esters / 20-oxosteroids / 3-oxosteroids / Cyclohexenones / Alpha-acyloxy ketones / Carboxylic acid esters / Monocarboxylic acids and derivatives / Organic oxides / Hydrocarbon derivatives
- Substituents
- 20-oxosteroid / 3-oxosteroid / Aliphatic homopolycyclic compound / Alpha-acyloxy ketone / Carbonyl group / Carboxylic acid derivative / Carboxylic acid ester / Cyclic ketone / Cyclohexenone / Hydrocarbon derivative
- Molecular Framework
- Aliphatic homopolycyclic compounds
- External Descriptors
- Not Available
Chemical Identifiers
- UNII
- 83J78V5W05
- CAS number
- 58652-20-3
- InChI Key
- IIVBFTNIGYRNQY-YQLZSBIMSA-N
- InChI
- InChI=1S/C23H30O4/c1-13-11-20-18(17-6-5-16(26)12-19(13)17)7-9-22(4)21(20)8-10-23(22,14(2)24)27-15(3)25/h11-12,17-18,20-21H,5-10H2,1-4H3/t17-,18-,20-,21+,22+,23+/m1/s1
- IUPAC Name
- (1R,3aS,3bS,9aR,9bS,11aS)-1-acetyl-5,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl acetate
- SMILES
- [H][[email protected]@]12CC[[email protected]](OC(C)=O)(C(C)=O)[[email protected]@]1(C)CC[[email protected]]1([H])[[email protected]@]3([H])CCC(=O)C=C3C(C)=C[[email protected]@]21[H]
References
- General References
- External Links
- KEGG Drug
- D08281
- ChemSpider
- 82771
- 53744
- ChEBI
- 135564
- ChEMBL
- CHEMBL1476022
- ZINC
- ZINC000003938628
- Wikipedia
- Nomegestrol_acetate
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Terminated Screening Contraception / Hypercoagulability 1 3 Completed Prevention Contraception 1 3 Terminated Prevention Contraception 1 3 Unknown Status Treatment Disseminated Sclerosis 1 3 Withdrawn Treatment Contraception 1 2 Completed Treatment Contraception 1 2 Completed Treatment Menstrual Cramps 1 1 Completed Not Available Contraception 1 1 Completed Other Healthy Volunteers 1 1 Withdrawn Basic Science Bioequivalence 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet, coated Oral 1.5 mg Tablet Oral 5 MG Tablet Oral 1.5 MG Tablet, coated Oral 2.5 mg Tablet, film coated Oral 2.5 mg - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.00415 mg/mL ALOGPS logP 3.46 ALOGPS logP 3.42 ChemAxon logS -5 ALOGPS pKa (Strongest Acidic) 17.72 ChemAxon pKa (Strongest Basic) -4.8 ChemAxon Physiological Charge 0 ChemAxon Hydrogen Acceptor Count 3 ChemAxon Hydrogen Donor Count 0 ChemAxon Polar Surface Area 60.44 Å2 ChemAxon Rotatable Bond Count 3 ChemAxon Refractivity 104.18 m3·mol-1 ChemAxon Polarizability 41.78 Å3 ChemAxon Number of Rings 4 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter Yes ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Enzymes
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- Substrate
- General Function
- Vitamin d3 25-hydroxylase activity
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
- Gene Name
- CYP3A4
- Uniprot ID
- P08684
- Uniprot Name
- Cytochrome P450 3A4
- Molecular Weight
- 57342.67 Da
References
- Binkowska M, Woron J: Progestogens in menopausal hormone therapy. Prz Menopauzalny. 2015 Jun;14(2):134-43. doi: 10.5114/pm.2015.52154. Epub 2015 Jun 22. [PubMed:26327902]
Drug created on January 20, 2018 08:25 / Updated on October 15, 2020 21:34
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