Aldehyde dehydrogenase, mitochondrial
Details
- Name
- Aldehyde dehydrogenase, mitochondrial
- Synonyms
- 1.2.1.3
- ALDH class 2
- ALDH-E2
- ALDHI
- ALDM
- Gene Name
- ALDH2
- UniProtKB Entry
- P05091Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0000265|Aldehyde dehydrogenase, mitochondrial MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPS TGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLA ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCG QIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPG FGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADM DWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGP QVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGP VMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQS PFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS
- Number of residues
- 517
- Molecular Weight
- 56380.93
- Theoretical pI
- 7.05
- GO Classification
- Functionsaldehyde dehydrogenase (NAD+) activity / carboxylesterase activity / electron transfer activity / glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity / NAD binding / nitroglycerin reductase activity / phenylacetaldehyde dehydrogenase activityProcessesaldehyde catabolic process / regulation of dopamine biosynthetic process / regulation of serotonin biosynthetic processComponentsmitochondrion
- General Function
- Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage
- Specific Function
- aldehyde dehydrogenase (NAD+) activity
- Pfam Domain Function
- Aldedh (PF00171)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Mitochondrion matrix
- Gene sequence
>lcl|BSEQ0009957|Aldehyde dehydrogenase, mitochondrial (ALDH2) ATGTTGCGCGCTGCCGCCCGCTTCGGGCCCCGCCTGGGCCGCCGCCTCTTGTCAGCCGCC GCCACCCAGGCCGTGCCTGCCCCCAACCAGCAGCCCGAGGTCTTCTGCAACCAGATTTTC ATAAACAATGAATGGCACGATGCCGTCAGCAGGAAAACATTCCCCACCGTCAATCCGTCC ACTGGAGAGGTCATCTGTCAGGTAGCTGAAGGGGACAAGGAAGATGTGGACAAGGCAGTG AAGGCCGCCCGGGCCGCCTTCCAGCTGGGCTCACCTTGGCGCCGCATGGACGCATCACAC AGGGGCCGGCTGCTGAACCGCCTGGCCGATCTGATCGAGCGGGACCGGACCTACCTGGCG GCCTTGGAGACCCTGGACAATGGCAAGCCCTATGTCATCTCCTACCTGGTGGATTTGGAC ATGGTCCTCAAATGTCTCCGGTATTATGCCGGCTGGGCTGATAAGTACCACGGGAAAACC ATCCCCATTGACGGAGACTTCTTCAGCTACACACGCCATGAACCTGTGGGGGTGTGCGGG CAGATCATTCCGTGGAATTTCCCGCTCCTGATGCAAGCATGGAAGCTGGGCCCAGCCTTG GCAACTGGAAACGTGGTTGTGATGAAGGTAGCTGAGCAGACACCCCTCACCGCCCTCTAT GTGGCCAACCTGATCAAGGAGGCTGGCTTTCCCCCTGGTGTGGTCAACATTGTGCCTGGA TTTGGCCCCACGGCTGGGGCCGCCATTGCCTCCCATGAGGATGTGGACAAAGTGGCATTC ACAGGCTCCACTGAGATTGGCCGCGTAATCCAGGTTGCTGCTGGGAGCAGCAACCTCAAG AGAGTGACCTTGGAGCTGGGGGGGAAGAGCCCCAACATCATCATGTCAGATGCCGATATG GATTGGGCCGTGGAACAGGCCCACTTCGCCCTGTTCTTCAACCAGGGCCAGTGCTGCTGT GCCGGCTCCCGGACCTTCGTGCAGGAGGACATCTATGATGAGTTTGTGGAGCGGAGCGTT GCCCGGGCCAAGTCTCGGGTGGTCGGGAACCCCTTTGATAGCAAGACCGAGCAGGGGCCG CAGGTGGATGAAACTCAGTTTAAGAAGATCCTCGGCTACATCAACACGGGGAAGCAAGAG GGGGCGAAGCTGCTGTGTGGTGGGGGCATTGCTGCTGACCGTGGTTACTTCATCCAGCCC ACTGTGTTTGGAGATGTGCAGGATGGCATGACCATCGCCAAGGAGGAGATCTTCGGGCCA GTGATGCAGATCCTGAAGTTCAAGACCATAGAGGAGGTTGTTGGGAGAGCCAACAATTCC ACGTACGGGCTGGCCGCAGCTGTCTTCACAAAGGATTTGGACAAGGCCAATTACCTGTCC CAGGCCCTCCAGGCGGGCACTGTGTGGGTCAACTGCTATGATGTGTTTGGAGCCCAGTCA CCCTTTGGTGGCTACAAGATGTCGGGGAGTGGCCGGGAGTTGGGCGAGTACGGGCTGCAG GCATACACTGAAGTGAAAACTGTCACAGTCAAAGTGCCTCAGAAGAACTCATAA
- Chromosome Location
- 12
- Locus
- 12q24.12
- External Identifiers
Resource Link UniProtKB ID P05091 UniProtKB Entry Name ALDH2_HUMAN GenBank Protein ID 28606 GenBank Gene ID X05409 GeneCard ID ALDH2 GenAtlas ID ALDH2 HGNC ID HGNC:404 PDB ID(s) 1CW3, 1NZW, 1NZX, 1NZZ, 1O00, 1O01, 1O02, 1O04, 1O05, 1ZUM, 2ONM, 2ONN, 2ONO, 2ONP, 2VLE, 3INJ, 3INL, 3N80, 3N81, 3N82, 3N83, 3SZ9, 4FQF, 4FR8, 4KWF, 4KWG, 5L13, 8DR9, 8SHS KEGG ID hsa:217 IUPHAR/Guide To Pharmacology ID 2595 NCBI Gene ID 217 - General References
- Braun T, Bober E, Singh S, Agarwal DP, Goedde HW: Evidence for a signal peptide at the amino-terminal end of human mitochondrial aldehyde dehydrogenase. FEBS Lett. 1987 May 11;215(2):233-6. [Article]
- Braun T, Bober E, Singh S, Agarwal DP, Goedde HW: Isolation and sequence analysis of a full length cDNA clone coding for human mitochondrial aldehyde dehydrogenase. Nucleic Acids Res. 1987 Apr 10;15(7):3179. [Article]
- Hsu LC, Bendel RE, Yoshida A: Genomic structure of the human mitochondrial aldehyde dehydrogenase gene. Genomics. 1988 Jan;2(1):57-65. [Article]
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Associated Data
- Bio-Entities
Bio-Entity Type Aldehyde dehydrogenase, mitochondrial (Humans) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Disulfiram approved yes target inhibitor Details NADH approved, nutraceutical unknown target Details Daidzin experimental yes target inhibitor Details Guanidine approved yes target inhibitor Details Crotonaldehyde experimental yes target inhibitor Details Nitroglycerin approved, investigational no enzyme substrate Details Amyl Nitrite approved unknown enzyme substrate Details Benzyl alcohol approved unknown enzyme substrate Details Nitric Oxide approved unknown enzyme inhibitor Details Paraldehyde approved, investigational no enzyme substrate Details Pentaerythritol tetranitrate approved unknown enzyme substrate Details Silodosin approved unknown enzyme substrate Details Nadide experimental yes target inhibitor Details Isoformononetin experimental yes target inhibitor Details Calcium carbimide approved, withdrawn yes target inhibitor Details