Search

Displaying results 91 - 100 of 135872 in total
  1. Pathway

    Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone

    smpdb.ca/view/SMP0000333
    Signaling

    In the ovary, the FSH receptor is necessary for follicular development and is expressed on the granulosa cells.

    Drugs: ATP · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Glycoprotein hormones alpha chain
  2. Pathway

    Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin

    smpdb.ca/view/SMP0000338
    Signaling

    LHCGRs are found in the ovary, testis, and many extragonadal tissues.In the ovary, the LHCG receptor is necessary for follicular maturation and ovulation, as well as luteal function. … In the male the LHCGR has been identified on the Leydig cells that are critical for testosterone production, and support spermatogenesis.

    Drugs: ATP · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Glycoprotein hormones alpha chain
  3. Pathway

    Metabolism and Physiological Effects of N-Acetyl-3-Methylhistidine

    smpdb.ca/view/SMP0126795
    Metabolic

    N-Acetyl-3-methylhistidine, an N-acetyl-L-amino acid, belongs to the class of organic compounds known as histidine and derivatives. … N-Acetyl-3-methylhistidine is an acetylated derivative of 3-methylhistidine and a very strong basic compound (based on its pKa).

    Drugs: Histidine · Ademetionine
  4. Pathway

    Metabolism and Physiological Effects of N-alpha-Acetyl-L-arginine

    smpdb.ca/view/SMP0125530
    Metabolic

    Arginnosuccinate is synthesized from citrulline and aspartic acid by the enzyme argininosuccinate synthase. That is catalyzed by argininosuccinate lyase to produce arginine and fumaric acid. … In the blood it works as a uremic toxin to cause kidney damage, cardiovascular disease and neurological deficits.

    Drugs: Pyridoxal phosphate · Arginine · Aspartic acid · Ornithine · L-Glutamine · Adenosine phosphate +10 more
  5. Pathway

    Ziconotide NMDA and Substance P Receptor Pain Inhibition Action Pathway

    smpdb.ca/view/SMP0126347
    Drug action

    such as intrathecal morphine and systemic analgesics. … This causes downstream nociceptive neuronal activity and pain perception. Substance P and CGRP both also induce inflammation, further exasperating chronic pain.

    Drugs: Glutamic acid · Calcium · Sar9, Met (O2)11-Substance P · Ziconotide
  6. Pathway

    Icosapent Prostaglandin G/H synthase 1 and 2 anti-inflammatory Action Pathway

    smpdb.ca/view/SMP0126557
    Drug action

    Icosapent is an important polyunsaturated fatty acid (eicosapentaenoic acid (EPA)). It is mostly found in fish oils. … A diet rich in this molecule can be used/started to lower elevated triglycerides level in patients who are hyperglyceridimic.

    Drugs: Glutathione · Icosapent · Dinoprostone · Calcium · Mesoheme · Prostaglandin G2 +1 more
  7. Pathway

    Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD)

    smpdb.ca/view/SMP0000542
    Disease

    Medium-chain acyl-CoA dehydrogenase deficiency, which is also known as MCADD, is a rare inherited inborn error of metabolism (IEM) medium-chain fatty acid metabolism. … MCADD is an autosomal recessive disorder associated with a mutation in the enzyme medium-chain acyl-CoA dehydrogenase (MCAD).

    Drugs: Adenosine phosphate · NADH · ATP · Levocarnitine · Magnesium cation · Flavin adenine dinucleotide +2 more
    Enzymes: Medium-chain specific acyl-CoA dehydrogenase, mitochondrial, Long-chain-fatty-acid--CoA ligase 1
  8. Pathway

    Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD)

    smpdb.ca/view/SMP0125743
    Disease

    Medium-chain acyl-CoA dehydrogenase deficiency, which is also known as MCADD, is a rare inherited inborn error of metabolism (IEM) medium-chain fatty acid metabolism. … MCADD is an autosomal recessive disorder associated with a mutation in the enzyme medium-chain acyl-CoA dehydrogenase (MCAD).

    Drugs: Adenosine phosphate · NADH · ATP · Levocarnitine · Magnesium cation · Flavin adenine dinucleotide +2 more
    Enzymes: Medium-chain specific acyl-CoA dehydrogenase, mitochondrial, Long-chain-fatty-acid--CoA ligase 1
  9. Pathway

    Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids

    smpdb.ca/view/SMP0000481
    Metabolic

    Medium to long chain fatty acids go directly to the mitochondria, whereas very long chain fatty acids (>22 carbons) may be first metabolized down to octanyl-CoA in the peroxisomes and then transported … Short and medium chain fatty acids can enter the mitochondria directly via diffusion where they are activated in the mitochondrial matrix by acyl-coenzyme A synthetases.

    Drugs: Adenosine phosphate · NADH · ATP · Magnesium cation · Lauric acid · Flavin adenine dinucleotide +1 more
    Enzymes: Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
  10. Pathway

    Mitochondrial Electron Transport Chain

    smpdb.ca/view/SMP0000355
    Metabolic

    The electron transport chain in mitochondria leads to the transport of hydrogen ions across the inner membrane of the mitochndria, and this proton gradient is eventually used in the production of ATP. … This step, unlike the others in the electron transport chain, does not result in any protons being pumped from the matrix to the intermembrane space.

    Drugs: Succinic acid · NADH · ATP · D-glyceraldehyde 3-phosphate · sn-glycerol 3-phosphate · Mesoheme +3 more