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Ribose-5-phosphate Isomerase Deficiency
smpdb.ca/view/SMP0125654DiseaseThere are other symptoms, including leukoencephalopathy and neuropathy, which may be caused by a toxic accumulation of ribitol and arabitol, or a potential lack of ribose-5-phosphate in RNA synthesis. … This combination meant that activity of RPI was found to vary across tissues and cell types.
Drugs: Adenosine phosphate · ATP · Magnesium cation · Iron · 5-O-phosphono-alpha-D-ribofuranosyl diphosphate · D-glyceraldehyde 3-phosphate +4 moreGLUT-1 Deficiency Syndrome
smpdb.ca/view/SMP0000580DiseaseThis disorder is characterized by dissipation of D-glucose in both Golgi apparatus and cell cytoplasm. Symptoms of the disorder include developmental delays of mental and motor. … GLUT1 deficiency syndrome, also called GLUT1-DS or De Vivo disease, is an autosomal dominant disorder and caused by a defective solute carrier family 2, facilitated glucose transporter member 1.
Ribose-5-phosphate Isomerase Deficiency
smpdb.ca/view/SMP0000519DiseaseThere are other symptoms, including leukoencephalopathy and neuropathy, which may be caused by a toxic accumulation of ribitol and arabitol, or a potential lack of ribose-5-phosphate in RNA synthesis. … This combination meant that activity of RPI was found to vary across tissues and cell types.
Drugs: Adenosine phosphate · ATP · Magnesium cation · Iron · 5-O-phosphono-alpha-D-ribofuranosyl diphosphate · D-glyceraldehyde 3-phosphate +4 moreAripiprazole Dopamine agonist Action Pathway
smpdb.ca/view/SMP0126454Drug actionAripiprazole may be administered with or without food and is available in oral tablets, disintegrating tablets (10 mg and 15 mg), oral solution, and intramuscular (IM) injections for acute symptoms and … It has a high affinity for D2, D3, 5HT-1a, and 5HT2a receptors and moderate affinity for D4, 5HT-2c, 5-HT7, alpha-1 adrenergic, and H1 receptors.
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorFluphenazine Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126501Drug actionFluphenazine blocks postsynaptic dopaminergic D1 and D2 receptors in the mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways in the brain; depresses the release of hypothalamic and hypophyseal … hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorSelegiline Action Pathway
smpdb.ca/view/SMP0126719Drug actionThe first one is found in cells located in the periphery and breakdown serotonin, norepinephrine, epinephrine, dopamine, and tyramine. … The monoamine oxidase is an enzyme that catalyzes the oxidative deamination of many amines like serotonin, norepinephrine, epinephrine, and dopamine. There are 2 isoforms of this protein: A and B.
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorRasagiline Action Pathway
smpdb.ca/view/SMP0126709Drug actionThe first one is found in cells located in the periphery and breakdown serotonin, norepinephrine, epinephrine, dopamine, and tyramine. … Rasagiline is a propargylamine and an irreversible monoamine oxidase inhibitor (MAOIs).
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorLactose Synthesis
smpdb.ca/view/SMP0000444MetabolicUDP-galactose is then transported into the Golgi by the UDP galactose translocator, an antiporter which uses facilitated transport to move UDP galactose into the Golgi and exports UMP. … Once inside the Golgi, the UDP galactose and glucose (which moves into the golgi via the GLUT-1 transporter) become substrates for the lactose synthase enzyme complex, comprised of the enzymatic subunit
Droperidol Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126486Drug actionDroperidol causes a CNS depression at subcortical levels of the brain, midbrain, and brainstem reticular formation. It may antagonize the actions of glutamic acid within the extrapyramidal system. … It is a butyrophenone derivative and dopamine antagonist used to prevent and treat postoperative nausea and vomiting.
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorFlupentixol Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126515Drug actionFlupentixol decanoate is one of the active ingredients found in injectable drug formulations: it is produced by esterification of cis(Z)‐flupentixol with decanoic acid. … Flupentixol is an antagonist of both D1 and D2 dopamine receptors. Flupentixol is an antipsychotic agent with anxiolytic and mild sedative actions.
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptor