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Metabolism and Physiological Effects of N-Acetyl-3-Methylhistidine
smpdb.ca/view/SMP0126795MetabolicN-Acetyl-3-methylhistidine, an N-acetyl-L-amino acid, belongs to the class of organic compounds known as histidine and derivatives. … N-Acetyl-3-methylhistidine is an acetylated derivative of 3-methylhistidine and a very strong basic compound (based on its pKa).
Metabolism and Physiological Effects of N-alpha-Acetyl-L-arginine
smpdb.ca/view/SMP0125530MetabolicArginnosuccinate is synthesized from citrulline and aspartic acid by the enzyme argininosuccinate synthase. That is catalyzed by argininosuccinate lyase to produce arginine and fumaric acid. … In the blood it works as a uremic toxin to cause kidney damage, cardiovascular disease and neurological deficits.
Drugs: Pyridoxal phosphate · Arginine · Aspartic acid · Ornithine · L-Glutamine · Adenosine phosphate +10 moreZiconotide NMDA and Substance P Receptor Pain Inhibition Action Pathway
smpdb.ca/view/SMP0126347Drug actionsuch as intrathecal morphine and systemic analgesics. … This causes downstream nociceptive neuronal activity and pain perception. Substance P and CGRP both also induce inflammation, further exasperating chronic pain.
Icosapent Prostaglandin G/H synthase 1 and 2 anti-inflammatory Action Pathway
smpdb.ca/view/SMP0126557Drug actionThis molecule also inhibits the arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families because it inhibits the prostaglandin G/H synthase 1 and 2 (COX-1 and COX-2). … Then icosapent shows anti-atherogenic and anti-thrombotic effects in cells. EPA serves as a substrate for Prostaglandin-endoperoxide synthase 1 and 2.
Fish oil Prostaglandin G/H synthase 1 and 2 anti-inflammatory Action Pathway
smpdb.ca/view/SMP0126563Drug actionEPA and DHA do competition with arachidonic acids for both COX-1 and COX-2 enzymes. … These are responsible for the conversion of arachidonic acid (an omega-6 fatty acid) into prostaglandins and thromboxanes, which are important mediators of inflammation and pain.
Sodium 1,2-Dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) Drug Metabolism
smpdb.ca/view/SMP0130668MetabolicSodium 1,2-Dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) passes through the liver and is then excreted from the body mainly through the kidney. … Sodium 1,2-Dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Glycerol Phosphate Shuttle
smpdb.ca/view/SMP0000124MetabolicThe glycerol phosphate shuttle also known as the glycerophosphate shuttle. It shuttles electrons to mitochondrial carriers in the oxidative phosphorylation pathway from cytosolic NADH. … This shuttle relies on mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH). This is also a common process for the cell to regenerate cytosolic NAD+ for other processes.
Drugs: NADH · D-glyceraldehyde 3-phosphate · sn-glycerol 3-phosphate · Flavin adenine dinucleotide · Dihydroxyacetone phosphateEnzymes: Glycerol-3-phosphate dehydrogenase, mitochondrial, Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmicGlycerol Kinase Deficiency
smpdb.ca/view/SMP0000187DiseaseA deficiency in this enzyme results in accumulation of glycerol in urine and serum. Symptoms include cryptorchism, trabismus, myopathy, lethargy, and vomiting. … Treatment includes corticosteroids and acute glucose infusion.
Drugs: NADH · ATP · sn-glycerol 3-phosphate · Flavin adenine dinucleotide · Palmitic Acid · Glycerin +1 moreEnzymes: Glycerol kinase, Glycerol-3-phosphate dehydrogenase, mitochondrialGlycerol Kinase Deficiency
smpdb.ca/view/SMP0125704DiseaseA deficiency in this enzyme results in accumulation of glycerol in urine and serum. Symptoms include cryptorchism, strabismus, myopathy, lethargy, and vomiting. … Treatment includes corticosteroids and acute glucose infusion.
Drugs: NADH · ATP · sn-glycerol 3-phosphate · Flavin adenine dinucleotide · Palmitic Acid · Glycerin +1 moreEnzymes: Glycerol kinase, Glycerol-3-phosphate dehydrogenase, mitochondrialD-Glyceric Aciduria
smpdb.ca/view/SMP0125705DiseaseD-Glyceric aciduria is an extremely rare inherited inborn error of metabolism (IEM) of serine and fructose metabolism. … Defects in the enzyme will lead to accumulations of D-glyceric acid in tissues and biofluids.
Drugs: NADH · ATP · sn-glycerol 3-phosphate · Flavin adenine dinucleotide · Palmitic Acid · Glycerin +1 moreEnzymes: Glycerol kinase, Glycerol-3-phosphate dehydrogenase, mitochondrial