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Ibrutinib
go.drugbank.com/drugs/DB09053ApprovedInvestigational[L45894] Ibrutinib was approved by the EMA in October 2014 [L45884] and by Health Canada in November 2014. … [A32299] Ibrutinib was developed by Pharmacyclics Inc and was first approved by the FDA in November 2013 for the treatment of mantle cell lymphoma (MCL) under accelerated approval;[L12228] however, in
Categories: Antineoplastic and Immunomodulating AgentsSynonyms: 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-oneTriptorelin
go.drugbank.com/drugs/DB06825ApprovedInvestigationalVet approvedAfter chronic, continuous administration, this agent effects sustained decreases in LH and FSH production and testicular and ovarian steroidogenesis. … Serum testosterone concentrations may fall to levels typically observed in surgically castrated men.
Categories: Hormones and Related Agents, Amino Acids, Peptides, and ProteinsProducts: Decapeptyl Depot - Retardmikrokapseln und Suspensionsmittel in Einmalspritzen, Triptofem 0,1 mg/ml Injektionslösung in einer FertigspritzeAntilymphocyte immunoglobulin (horse)
go.drugbank.com/drugs/DB09312ApprovedInvestigationalIt is formed by inoculating a horse with an antigen (human thymoyctes) which then induces the horse immune system's B-lymphocytes to produce IgG immunoglobulins specific for that antigen. … Induction of T cell apoptosis and resulting T-cell lymphopenia found in vivo is credited for its therapeutic effect in these conditions.
Categories: Fluids and Secretions, Amino Acids, Peptides, and ProteinsProducts: Atgam Sterile Solution IV 50mg/ml, ATGAM 50MG/ML STERILE SOLUTION (5ML AMP)Norepinephrine
go.drugbank.com/drugs/DB00368ApprovedInvestigationalPrecursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. … It is also found in plants and is used pharmacologically as a sympathomimetic.
Categories: Epinephrine and similars, Adrenergic and Dopaminergic AgentsProducts: Levophed Liq IV 1.0mg/ml, Norepinephrine Bitartrate In Sodium ChlorideIntracellular Signalling Through PGD2 receptor and Prostaglandin D2
smpdb.ca/view/SMP0000343SignalingProstaglandin D2 (PGD2) can trigger asthmatic responses by acting as a cell-derived mediator in mice.
Metabolism and Physiological Effects of Indole Acetic Acid
smpdb.ca/view/SMP0123235MetabolicIndole acetic acid is shown to cause inflammation and disrupt the electron transport chain and oxidative phosphorylation causing muscle atrophy. … After being transported into gut microbes, tryptophan undergoes a reaction with the enzymes tryptophan monooxygenase and indole-3-acetamide hydrolase to form indole acetic acid.
Drugs: TryptophanMetabolism and Physiological Effects of Para-cresyl glucuronide
smpdb.ca/view/SMP0123299MetabolicPara-cresyl glucuronide (P-cresyl glucuronide) is a phenolic compound that is formed through gut microbial metabolism from dietary tyrosine and a glucuronidation reaction in liver hepatic cells. … P-cresyl glucuronide is shown to induce stress in renal tubule cells as well as the effect shared by p-cresyl sulphate in causing enhanced oxidative stress.
Metabolism and Physiological Effects of 4-Hydroxyhippuric Acid
smpdb.ca/view/SMP0125537MetabolicBenzoic acid can also be synthesized by gut microbes through phenylalanine, however the exact mechanisms of synthesis in microbes is not well studied. … Benzoic acid is present in many fruits, such as apricots, prunes, and berries; many vegetables such as mushrooms (fungus), snap peas, cucumbers, and radishes; spices such as cinnamon, cloves, and allspice
Metabolism and Physiological Effects of p-Cresol sulphate
smpdb.ca/view/SMP0126850MetabolicIn the gut mucosa and in the liver, the majority of p-cresol will be conjugated into the uremic toxin p-cresyl sulfate by aryl sulfotransferases (EC 2.8.2.1.). … , catalysed by p-hydroxyphenylpyruvate oxidase (EC 1.2.3.13.), and can subsequently lead to the formation of p-cresol by p-hydroxyphenylacetate decarboxylase.
Amobarbital
go.drugbank.com/drugs/DB01351ApprovedIllicitA barbiturate with hypnotic and sedative properties (but not antianxiety). … Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565)
Categories: Hypnotics and SedativesProducts: Amytal Sodium 500mg, Amytal Sodium Cap 60mg