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Displaying results 1001 - 1010 of 3599 in total
  1. Target

    C-C chemokine receptor type 2

    go.drugbank.com/bio_entities/BE0003387
    TargetHumans

    Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B (PubMed:23938203). … Key functional receptor for CCL2 but can also bind CCL7, and CCL12 (PubMed:23408426, PubMed:38157855, PubMed:8048929, PubMed:8146186). Also transduces signaling mediated by CCL13 (PubMed:38157855).

    Polypeptides: C-C chemokine receptor type 2Synonyms: Monocyte chemoattractant protein 1 receptor
  2. Target

    C-C chemokine receptor type 1

    go.drugbank.com/bio_entities/BE0003509
    TargetHumans

    Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses (PubMed:14991608).

    Polypeptides: C-C chemokine receptor type 1Synonyms: LD78 receptor, Macrophage inflammatory protein 1-alpha receptor
  3. Target

    Receptor-type tyrosine-protein phosphatase S

    go.drugbank.com/bio_entities/BE0003567
    TargetHumans

    Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan (PubMed:21454754).

    Polypeptides: Receptor-type tyrosine-protein phosphatase SSynonyms: Receptor-type tyrosine-protein phosphatase sigma
  4. Target

    Receptor-type tyrosine-protein phosphatase epsilon

    go.drugbank.com/bio_entities/BE0003568
    TargetHumans

    Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity)

    Polypeptides: Receptor-type tyrosine-protein phosphatase epsilon
  5. Target

    Neuronal acetylcholine receptor subunit beta-4

    go.drugbank.com/bio_entities/BE0003584
    TargetHumans

    CHRNA3:CHRNB4 being predominant in neurons of the autonomic ganglia, it is known as ganglionic nicotinic receptor (PubMed:31488329).

    Polypeptides: Neuronal acetylcholine receptor subunit beta-4Function: acetylcholine receptor activity
  6. Target

    Neuronal acetylcholine receptor subunit alpha-6

    go.drugbank.com/bio_entities/BE0003587
    TargetHumans

    Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collecti...

    Polypeptides: Neuronal acetylcholine receptor subunit alpha-6Function: acetylcholine receptor activity
  7. Target

    Neuronal acetylcholine receptor subunit beta-3

    go.drugbank.com/bio_entities/BE0003588
    TargetHumans

    Modulates receptor assembly and increases receptor sensitivity to nicotine when associated with CHRNB2, CHRNA4 and/or CHRNA6 as well as CHRNA3 and CHRNB4 (PubMed:11118490, PubMed:16835356).

    Polypeptides: Neuronal acetylcholine receptor subunit beta-3
  8. Target

    Gamma-aminobutyric acid receptor subunit epsilon

    go.drugbank.com/bio_entities/BE0003595
    TargetHumans

    Epsilon subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:16412217, PubMed:9882711). GABA-gated chloride channels, also named G...

    Polypeptides: Gamma-aminobutyric acid receptor subunit epsilonSynonyms: GABA(A) receptor subunit epsilon
  9. Target

    Cation-independent mannose-6-phosphate receptor

    go.drugbank.com/bio_entities/BE0003623
    TargetTransporterHumans

    The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523). This receptor also binds IGF2 (PubMed:18046459). … Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal

    Polypeptides: Cation-independent mannose-6-phosphate receptorSynonyms: IGF-II receptor, CI Man-6-P receptor
  10. Target

    Non-receptor tyrosine-protein kinase TYK2

    go.drugbank.com/bio_entities/BE0004146
    TargetHumans

    Involved in the oncostatin-M-mediated signaling pathway through both type I OSM receptor complex (heterodimers composed of LIFR and IL6ST) and type II OSM receptor complex (heterodimers composed of OSMR … The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2

    Polypeptides: Non-receptor tyrosine-protein kinase TYK2