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Displaying results 1061 - 1070 of 10000 in total
  1. Pathway

    Betaine Metabolism

    smpdb.ca/view/SMP0000123
    Metabolic

    In the liver, betaine functions as a methyl donor similar to choline, folic acid, S-adenosyl methionine and vitamin B12.

    Drugs: Tetrahydrofolic acid · Ademetionine · Choline · Methionine · NADH · ATP +8 more
    Enzymes: S-adenosylmethionine synthase isoform type-2, Betaine--homocysteine S-methyltransferase 1
  2. Drug

    Stiripentol

    go.drugbank.com/drugs/DB09118
    ApprovedInvestigational

    [A19739] Approved in the US, Canada, and Europe, stiripentol is used to treat seizures associated with Dravet syndrome.[L880,L42500,L42510] It is marketed under the brand name Diacomit. … Stiripentol may also exhibit direct anticonvulsant properties, although the exact mechanism of action is fully understood.

    Categories: Cytochrome P-450 CYP1A2 Inducers, P-glycoprotein inhibitorsSynonyms: 1-(1,3-Benzodioxol-5-yl)-4,4-dimethyl-1-penten-3-ol, 4,4-Dimethyl-1-((3,4-methylenedioxy)phenyl)-1-penten-3-ol
  3. Pathway

    Methionine Adenosyltransferase Deficiency

    smpdb.ca/view/SMP0125683
    Disease

    Methionine adenosyltransferase (MAT; Hypermethioninemia; MAT I/III deficiency) deficiency is caused by mutations in the MAT1A gene which causes isolated hypermethioninemia. MAT catalyzes the formation of adenosylmethionine from methionin...

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 more
    Enzymes: S-adenosylmethionine decarboxylase proenzyme, S-methyl-5'-thioadenosine phosphorylase
  4. Drug

    Talc

    go.drugbank.com/drugs/DB09511
    ApprovedInvestigational

    Talc is a mineral composed primarily of magnesium, silicon and oxygen. … Although talc has been widely used for decades, lawsuits that have come to the surface claim serious health complications linked to its use.

    Synonyms: E-553(III)Categories: Compounds used in a research, industrial, or household setting
  5. Target

    Cyclopropane mycolic acid synthase 1

    go.drugbank.com/bio_entities/BE0003738
    TargetMycobacterium tuberculosis

    Catalyzes the conversion of a double bond to a cyclopropane ring at the distal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine.

    Synonyms: S-adenosylmethionine-dependent methyltransferase
  6. Pathway

    Glycine N-Methyltransferase Deficiency

    smpdb.ca/view/SMP0125681
    Disease

    GNMT catalyzes the conversion of glycine into N-methylglycine (sarcosine) using S-adenosylmethionine (SAM or AdoMet).

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 more
    Enzymes: S-adenosylmethionine decarboxylase proenzyme, S-methyl-5'-thioadenosine phosphorylase
  7. Target

    Cyclopropane mycolic acid synthase 2

    go.drugbank.com/bio_entities/BE0001211
    TargetMycobacterium tuberculosis

    cyclopropanated ketomycolate or methoxymycolate through the conversion of a double bond to a cyclopropane ring at the proximal position of an oxygenated mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine

    Synonyms: S-adenosylmethionine-dependent methyltransferase
  8. Drug

    Silicon dioxide

    go.drugbank.com/drugs/DB11132
    Approved

    Inhalation of fine crystals is toxic to humans leading to respiratory toxicity. In powdered food products and pharmaceutical tablets, silicon dioxide is added as a flow agent to absorb water. … Silicon dioxide, or silica, is an oxide of silicon with the chemical formula SiO2.

    Mixtures: Unique Propoli Toothpas te, DOCTRUST ONE S ToothCategories: Compounds used in a research, industrial, or household setting
  9. Pathway

    Hypermethioninemia

    smpdb.ca/view/SMP0125679
    Disease

    This gene is responsible for Adenosylhomocysteinase, an enzyme which takes S-adenosyl homocysteine as input, and produces homocysteine as its output.

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 more
    Enzymes: S-adenosylmethionine decarboxylase proenzyme, S-methyl-5'-thioadenosine phosphorylase
  10. Drug

    Cinacalcet

    go.drugbank.com/drugs/DB01012
    ApprovedInvestigational

    Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia and as Mimpara® in Europe. … It is used to treat hyperparathyroidism due to parathyroid tumours or renal failure.

    Synonyms: (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethane amine, N-((1R)-1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amineCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Substrates