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Peroxisome proliferator-activated receptor delta
go.drugbank.com/bio_entities/BE0001007TargetHumansLigand-activated transcription factor key mediator of energy metabolism in adipose tissues (PubMed:35675826). Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. … Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes.
Polypeptides: Peroxisome proliferator-activated receptor deltaSynonyms: Peroxisome proliferator-activated receptor betaMitogen-activated protein kinase 3
go.drugbank.com/bio_entities/BE0001062TargetHumansMAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. … Phosphorylates GJA1 at 'Ser-279' and 'Ser-282' resulting in an increase in GJA1 ubiquitination and ultimately lysosomal degradation (By similarity)
Polypeptides: Mitogen-activated protein kinase 3Mitogen-activated protein kinase 11
go.drugbank.com/bio_entities/BE0003390TargetHumansIn the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. … MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2 (PubMed:11154262).
Polypeptides: Mitogen-activated protein kinase 11Synonyms: Stress-activated protein kinase 2b, Mitogen-activated protein kinase p38 betaMitogen-activated protein kinase 9
go.drugbank.com/bio_entities/BE0003772TargetHumansWhen activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway (PubMed:19675674). … Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels (PubMed:19290929).
Polypeptides: Mitogen-activated protein kinase 9Synonyms: Stress-activated protein kinase 1a, Stress-activated protein kinase JNK2Mitogen-activated protein kinase 15
go.drugbank.com/bio_entities/BE0009475TargetHumansControls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory … In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of
Polypeptides: Mitogen-activated protein kinase 15Mitogen-activated protein kinase 1
go.drugbank.com/bio_entities/BE0000923TargetHumansMAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. … Phosphorylates GJA1 at 'Ser-279' and 'Ser-282' resulting in an increase in GJA1 ubiquitination and ultimately lysosomal degradation (By similarity).
Polypeptides: Mitogen-activated protein kinase 1Synonyms: Mitogen-activated protein kinase 2Mitogen-activated protein kinase 14
go.drugbank.com/bio_entities/BE0001019TargetHumansIn the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. … Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets.
Polypeptides: Mitogen-activated protein kinase 14Synonyms: Stress-activated protein kinase 2a, Mitogen-activated protein kinase p38 alphaMitogen-activated protein kinase 10
go.drugbank.com/bio_entities/BE0001097TargetHumansIn this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. … In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity.
Polypeptides: Mitogen-activated protein kinase 10Synonyms: Stress-activated protein kinase 1b, Stress-activated protein kinase JNK3Soluble calcium-activated nucleotidase 1
go.drugbank.com/bio_entities/BE0001746TargetHumansCalcium-dependent nucleotidase with a preference for ribonucleosides diphosphate UDP, GDP and IDP, while having very low activity towards ADP and CDP (PubMed:12234496, PubMed:15006348, PubMed:15248776, … Does not hydrolyze AMP and GMP (PubMed:12234496). Involved in proteoglycan synthesis (PubMed:22539336)
Polypeptides: Soluble calcium-activated nucleotidase 1Mitogen-activated protein kinase 12
go.drugbank.com/bio_entities/BE0002790TargetHumansSome of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. … Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure.
Polypeptides: Mitogen-activated protein kinase 12Synonyms: Stress-activated protein kinase 3, Mitogen-activated protein kinase p38 gamma