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Displaying results 101 - 110 of 273 in total
  1. Target

    Fatty-acid amide hydrolase 2

    go.drugbank.com/bio_entities/BE0015331
    EnzymeHumans

    Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates … Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as

    Polypeptides: Fatty-acid amide hydrolase 2Synonyms: Oleamide hydrolase 2
  2. Target

    Pregnancy zone protein

    go.drugbank.com/bio_entities/BE0009089
    TargetHumans

    Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase

    Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6
  3. Target

    Serine/threonine-protein kinase ATR

    go.drugbank.com/bio_entities/BE0010060
    TargetHumans

    Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RBBP8, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis (PubMed:11114888, PubMed … Involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability and catalyzing phosphorylation of LMNA at '

    Synonyms: Ataxia telangiectasia and Rad3-related protein
  4. Target

    Cytoplasmic tyrosine-protein kinase BMX

    go.drugbank.com/bio_entities/BE0009416
    TargetHumans

    , cell adhesion, and apoptosis. … May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells

    Synonyms: Epithelial and endothelial tyrosine kinase, Bone marrow tyrosine kinase gene in chromosome X protein
  5. Target

    Potassium channel subfamily T member 1

    go.drugbank.com/bio_entities/BE0015369
    TargetHumans

    Contributes to synaptic development and plasticity (By similarity) … Acts as an important mediator of neuronal membrane excitability (PubMed:37494189). Contributes to the delayed outward currents (By similarity).

    Synonyms: Sodium and chloride-activated ATP-sensitive potassium channel Slo2.2
  6. Target

    Fatty-acid amide hydrolase 1

    go.drugbank.com/bio_entities/BE0002194
    TargetEnzymeHumans

    FAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N-fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets … Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (PubMed:17015445, PubMed:9122178).

    Polypeptides: Fatty-acid amide hydrolase 1Synonyms: Oleamide hydrolase 1, Fatty acid ester hydrolase
  7. Target

    3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

    go.drugbank.com/bio_entities/BE0004327
    TargetHumans

    Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. … Also hydrolyzes 3-hydroxypropanoyl-CoA

    Polypeptides: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrialSynonyms: HIB-CoA hydrolase, 3-hydroxyisobutyryl-coenzyme A hydrolase
  8. Target

    Ubiquitin carboxyl-terminal hydrolase 14

    go.drugbank.com/bio_entities/BE0009040
    TargetHumans

    Inhibits OPTN-mediated selective autophagic degradation of KDM4D and thereby negatively regulates H3K9me2 and H3K9me3 (PubMed:35145029) … Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity).

    Polypeptides: Ubiquitin carboxyl-terminal hydrolase 14
  9. Target

    Ubiquitin C-terminal hydrolase 7

    go.drugbank.com/bio_entities/BE0018040
    TargetHumans

    Hydrolase that deubiquitinates target proteins such as ARMC5, FOXO4, DEPTOR, KAT5, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX (PubMed:11923872, PubMed:15053880, PubMed:16964248, PubMed … Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis (PubMed:11923872, PubMed

    Polypeptides: Ubiquitin C-terminal hydrolase 7
  10. Target

    Spermidine/spermine N(1)-acetyltransferase

    go.drugbank.com/bio_entities/BE0001716
    TargetBacillus subtilis (strain 168)

    Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. … Could also be involved in the negative control of sporulation as well as production of degradative enzymes such as alpha-amylase, levansucrase and alkaline phosphatase.

    Synonyms: Protease synthase and sporulation negative regulatory protein PAI 1