Search
Serine/threonine-protein kinase ATR
go.drugbank.com/bio_entities/BE0010060TargetHumansPhosphorylates BRCA1, CHEK1, MCM2, RAD17, RBBP8, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis (PubMed:11114888, PubMed … Involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability and catalyzing phosphorylation of LMNA at '
Synonyms: Ataxia telangiectasia and Rad3-related proteinLecithin retinol acyltransferase
go.drugbank.com/bio_entities/BE0000900TargetEnzymeHumansRequired for the survival of cone photoreceptors and correct rod photoreceptor cell morphology (By similarity) … converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments (Probable).
Synonyms: Phosphatidylcholine--retinol O-acyltransferasePotassium channel subfamily T member 1
go.drugbank.com/bio_entities/BE0015369TargetHumansContributes to synaptic development and plasticity (By similarity) … Acts as an important mediator of neuronal membrane excitability (PubMed:37494189). Contributes to the delayed outward currents (By similarity).
Synonyms: Sodium and chloride-activated ATP-sensitive potassium channel Slo2.2Cystathionine gamma-synthase
go.drugbank.com/bio_entities/BE0003209TargetEnzymeEscherichia coli (strain K12)Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. … In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia.
Synonyms: O-succinylhomoserine (thiol)-lyaseSpermidine/spermine N(1)-acetyltransferase
go.drugbank.com/bio_entities/BE0001716TargetBacillus subtilis (strain 168)Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. … Could also be involved in the negative control of sporulation as well as production of degradative enzymes such as alpha-amylase, levansucrase and alkaline phosphatase.
Synonyms: Protease synthase and sporulation negative regulatory protein PAI 1Cell growth-regulating nucleolar protein
go.drugbank.com/bio_entities/BE0008958TargetMousePlays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (By similarity). … Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (By similarity).
Synonyms: Protein expressed in male leptotene and zygotene spermatocytes 264Zinc transporter ZIP5
go.drugbank.com/bio_entities/BE0009888TransporterHumansUniporter that transports zinc(2+) into polarized cells of enterocytes, pancreatic acinar and endoderm cells across the basolateral membrane and participates, notably, in zinc excretion from the intestine … The transport mechanism is temperature- and concentration-dependent and saturable (By similarity). In addition, is also a high affinity copper transporter in vitro (PubMed:36454509).
Synonyms: Zrt- and Irt-like protein 5Threonine-phosphate decarboxylase
go.drugbank.com/bio_entities/BE0001652TargetSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.
Synonyms: L-threonine-O-3-phosphate decarboxylaseStabilin-2
go.drugbank.com/bio_entities/BE0004948TargetHumansBinds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. … The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalization as well as HA and CS
Synonyms: FAS1 EGF-like and X-link domain-containing adhesion molecule 2, Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2Prolyl 3-hydroxylase 1
go.drugbank.com/bio_entities/BE0002202TargetEnzymeHumansHas prolyl 3-hydroxylase activity and catalyzes the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in pro-collagen chains, a critical step for the formation of mature collagen
Synonyms: Leucine- and proline-enriched proteoglycan 1