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Isoniazid Metabolism
smpdb.ca/view/SMP0121102MetabolicIt can alternatively be processed by cytochrome P450 2E1 into hepatotoxins, which are then joined to glutatione by glutatione S-transferase omega-2 to form R-S-glutatione, which is then excreted.
Enzymes: Glutathione S-transferase omega-2Dobutamine
go.drugbank.com/drugs/DB00841ApprovedInvestigationalA beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery.
Mixtures: DOCARIP® 1 MG/MLCategories: Adrenergic alpha-1 Receptor Agonists, Adrenergic beta-1 Receptor AgonistsThiamine
go.drugbank.com/drugs/DB00152ApprovedInvestigationalNutraceuticalVet approvedThiamine cannot be stored in the body; however, once absorbed, the vitamin is concentrated in muscle tissue. … It is essential for normal growth and development and helps to maintain proper functioning of the heart and the nervous and digestive systems.
Synonyms: Vitamin B 1, thiamine(1+)International brands: Betalin SCopper
go.drugbank.com/drugs/DB09130ApprovedInvestigationalCopper is a transition metal and a trace element in the body. It is important to the function of many enzymes including cytochrome c oxidase, monoamine oxidase and superoxide dismutase [FDA Label]. … Copper is commonly used in contraceptive intrauterine devices (IUD) [L801].
Mixtures: KORDEL`S NUTRITIME TABLET, KORDEL`S CALCIUM & MAGNESIUM PLUS TABLETProducts: ParaGard T 380AEtoperidone
go.drugbank.com/drugs/DB09194ApprovedWithdrawnEtoperidone is an atypical antidepressant introduced in Europe in 1977. … It is a phenylpiperazine-substituted triazole derivative with a composition that classifies it as an analog of tradozone and presents a similar pharmacological profile.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Heterocyclic Compounds, 1-RingIntracellular Signalling Through Prostacyclin Receptor and Prostacyclin
smpdb.ca/view/SMP0000354SignalingCyclooxygenase is the major producer of prostacyclin. Prostacyclin binding to its receptor increases vasodilation and decreases platelet aggregation. The receptor is a G-protein coupled receptor, upon its binding it activates G proteins ...
Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12Rotigotine
go.drugbank.com/drugs/DB05271ApprovedInvestigationalRotigotine (Neupro) is a non-ergoline dopamine agonist indicated for the treatment of Parkinson's disease (PD) and restless legs syndrome (RLS) in Europe and the United States. … However, all Neupro patches in the United States and some of Europe were recalled in 2008 due to delivery mechanism issues. Rotigotine has been authorized as a treatment for RLS since August 2008.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Cytochrome P-450 SubstratesSynonyms: (6S)-6-(propyl(2-(2-thienyl)ethyl)amino)-5,6,7,8-tetrahydro-1-naphthalenolVitamin D
go.drugbank.com/drugs/DB11094ApprovedInvestigationalNutraceuticalVet approvedThere are several different vitamin D supplements that are given to treat or to prevent osteomalacia and rickets, or to meet the daily criteria of vitamin D consumption. … Since vitamin D can be endogenously synthesized in adequate amounts by most mammals exposed to sufficient quantities of sunlight, vitamin D functions like a hormone on vitamin D receptors to regulate calcium
Synonyms: D Vitamin, Vitamin DMixtures: SCOTT`S EMULSION VITA ORANGE Cod Liver Oil Extra, WOMEN`S MULTIVITE WITH EVENING PRIMROSE OIL,ROYAL JELLY & KOREAN GINSENGSarcosine Oncometabolite Pathway
smpdb.ca/view/SMP0002313DiseaseS-adenosylmethionine then reacts with glycine reversibly to form S-adenosylhomocysteine, as well as sarcosine. … consisting of S-adenosylmethionine synthase and methionine adenosyltransferase.
Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Serine · Methionine +10 moreEnzymes: S-adenosylmethionine synthase isoform type-2, Betaine--homocysteine S-methyltransferase 1Azathioprine Action Pathway (New)
smpdb.ca/view/SMP0126488Drug actionAzathioprine was synthesized in 1956 to produce a 6-mercaptopurine derivative with a better therapeutic index.
Drugs: Tetrahydrofolic acid · Ademetionine · L-Glutamine · Adenosine phosphate · Glutamic acid · Glycine +13 moreEnzymes: Glutathione S-transferase A3, Thiopurine S-methyltransferase