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Displaying results 1101 - 1110 of 3735 in total
  1. Target

    High affinity immunoglobulin epsilon receptor subunit gamma

    go.drugbank.com/bio_entities/BE0000049
    TargetHumans

    As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. … As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset.

    Polypeptides: High affinity immunoglobulin epsilon receptor subunit gammaSynonyms: Fc receptor gamma-chain, IgE Fc receptor subunit gamma
  2. Target

    Gamma-aminobutyric acid receptor subunit rho-1

    go.drugbank.com/bio_entities/BE0000129
    TargetHumans

    Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (PubMed:37659407). Rho-containing GABA-gated chlorid...

    Polypeptides: Gamma-aminobutyric acid receptor subunit rho-1Synonyms: GABA(C) receptor, GABA(A) receptor subunit rho-1
  3. Target

    Mast/stem cell growth factor receptor Kit

    go.drugbank.com/bio_entities/BE0000453
    TargetHumans

    KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. … Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B.

    Polypeptides: Mast/stem cell growth factor receptor Kit
  4. Target

    Gamma-aminobutyric acid receptor subunit alpha-4

    go.drugbank.com/bio_entities/BE0000478
    TargetHumans

    Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:35355020). GABA-gated chloride channels, also named GABA(A) receptors (...

    Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-4Synonyms: GABA(A) receptor subunit alpha-4
  5. Target

    Tyrosine-protein phosphatase non-receptor type 1

    go.drugbank.com/bio_entities/BE0000623
    TargetHumans

    May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET

    Polypeptides: Tyrosine-protein phosphatase non-receptor type 1
  6. Target

    C-X-C chemokine receptor type 4

    go.drugbank.com/bio_entities/BE0000919
    TargetHumans

    Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed … Also acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels (PubMed:20228059).

    Polypeptides: C-X-C chemokine receptor type 4Synonyms: SDF-1 receptor, Stromal cell-derived factor 1 receptor
  7. Target

    Low-density lipoprotein receptor-related protein 2

    go.drugbank.com/bio_entities/BE0000942
    TargetTransporterHumans

    Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). … Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity).

    Polypeptides: Low-density lipoprotein receptor-related protein 2
  8. Target

    Tumor necrosis factor receptor superfamily member 5

    go.drugbank.com/bio_entities/BE0001196
    TargetHumans

    Receptor for TNFSF5/CD40LG (PubMed:31331973).

    Polypeptides: Tumor necrosis factor receptor superfamily member 5Synonyms: CD40L receptor
  9. Target

    Prolow-density lipoprotein receptor-related protein 1

    go.drugbank.com/bio_entities/BE0002110
    TargetHumans

    Acts as an LRPAP1 alpha-2-macroglobulin receptor (PubMed:1702392, PubMed:26142438). … Also acts as a receptor for IGFBP3 to mediate cell growth inhibition (PubMed:9252371)

    Polypeptides: Prolow-density lipoprotein receptor-related protein 1Synonyms: Apolipoprotein E receptor, Alpha-2-macroglobulin receptor
  10. Target

    Gamma-aminobutyric acid receptor subunit beta-3

    go.drugbank.com/bio_entities/BE0002345
    TargetHumans

    Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:14993607, PubMed:18514161, PubMed:22243422, PubMed:22303015, PubMed:2490...

    Polypeptides: Gamma-aminobutyric acid receptor subunit beta-3Synonyms: GABA(A) receptor subunit beta-3