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Displaying results 1131 - 1140 of 3735 in total
  1. Drug

    Vincristine

    go.drugbank.com/drugs/DB00541
    ApprovedInvestigational

    Vincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. It is marketed under several brand names, many of which have different formulations such as Marqibo (liposomal injection) and Vincasar. Vincristine is indicated for th...

    Categories: P-glycoprotein inducers, P-glycoprotein inhibitors
  2. Target

    Gamma-aminobutyric acid receptor subunit alpha-2

    go.drugbank.com/bio_entities/BE0000381
    TargetHumans

    Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10449790, PubMed:29961870, PubMed:31032849). GABA-gated chloride channe...

    Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-2Synonyms: GABA(A) receptor subunit alpha-2
  3. Target

    Gamma-aminobutyric acid receptor subunit alpha-5

    go.drugbank.com/bio_entities/BE0000471
    TargetHumans

    Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:14993607, PubMed:29961870, PubMed:30140029, PubMed:31056671). GABA-gate...

    Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-5Synonyms: GABA(A) receptor subunit alpha-5
  4. Target

    Gamma-aminobutyric acid receptor subunit alpha-3

    go.drugbank.com/bio_entities/BE0000523
    TargetHumans

    Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:16412217, PubMed:29053855). GABA-gated chloride channels, also named GA...

    Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-3Synonyms: GABA(A) receptor subunit alpha-3
  5. Target

    Gamma-aminobutyric acid receptor subunit alpha-1

    go.drugbank.com/bio_entities/BE0000795
    TargetHumans

    GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response (By similarity).

    Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-1Synonyms: GABA(A) receptor subunit alpha-1
  6. Target

    Tumor necrosis factor receptor superfamily member 1B

    go.drugbank.com/bio_entities/BE0000949
    TargetHumans

    Receptor with high affinity for TNFSF2/TNF and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. … This receptor mediates most of the metabolic effects of TNF. Isoform 2 blocks TNF-induced apoptosis, which suggests that it regulates TNF function by antagonizing its biological activity

    Polypeptides: Tumor necrosis factor receptor superfamily member 1BSynonyms: p80 TNF-alpha receptor, Tumor necrosis factor receptor 2
  7. Target

    Tyrosine-protein phosphatase non-receptor type 11

    go.drugbank.com/bio_entities/BE0001071
    TargetHumans

    Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed:14739280, PubMed:18559669 … Acts as an effector of PDCD1-mediated inhibition of T-cell response: recruited by phosphorylated PDCD1, mediating dephosphorylation of key T-cell receptor (TCR) proximal signaling molecules, leading to

    Polypeptides: Tyrosine-protein phosphatase non-receptor type 11
  8. Target

    Proto-oncogene tyrosine-protein kinase receptor Ret

    go.drugbank.com/bio_entities/BE0002411
    TargetHumans

    Acts as a dependence receptor via the GDNF-GFRA1 signaling: in the presence of the ligand GDNF in somatotrophs within pituitary, promotes survival and down regulates growth hormone (GH) production, but … Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner (PubMed:20702524, PubMed:21357690).

    Polypeptides: Proto-oncogene tyrosine-protein kinase receptor Ret
  9. Target

    Tumor necrosis factor receptor superfamily member 8

    go.drugbank.com/bio_entities/BE0003479
    TargetHumans

    Receptor for TNFSF8/CD30L (PubMed:8391931). May play a role in the regulation of cellular growth and transformation of activated lymphoblasts.

    Polypeptides: Tumor necrosis factor receptor superfamily member 8Synonyms: CD30L receptor
  10. Target

    Parathyroid hormone/parathyroid hormone-related peptide receptor

    go.drugbank.com/bio_entities/BE0003508
    TargetHumans

    G protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH) (PubMed:10913300, PubMed:11773434, PubMed:18375760, PubMed:19674967, PubMed:27160269, PubMed … Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP

    Polypeptides: Parathyroid hormone/parathyroid hormone-related peptide receptorSynonyms: PTH1 receptor, PTH/PTHr receptor