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Gamma-aminobutyric acid receptor subunit rho-1
go.drugbank.com/bio_entities/BE0000129TargetHumansRho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (PubMed:37659407). Rho-containing GABA-gated chlorid...
Polypeptides: Gamma-aminobutyric acid receptor subunit rho-1Synonyms: GABA(C) receptor, GABA(A) receptor subunit rho-1Mast/stem cell growth factor receptor Kit
go.drugbank.com/bio_entities/BE0000453TargetHumansKIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. … Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B.
Polypeptides: Mast/stem cell growth factor receptor KitGamma-aminobutyric acid receptor subunit alpha-4
go.drugbank.com/bio_entities/BE0000478TargetHumansAlpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:35355020). GABA-gated chloride channels, also named GABA(A) receptors (...
Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-4Synonyms: GABA(A) receptor subunit alpha-4Tyrosine-protein phosphatase non-receptor type 1
go.drugbank.com/bio_entities/BE0000623TargetHumansMay also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET
Polypeptides: Tyrosine-protein phosphatase non-receptor type 1C-X-C chemokine receptor type 4
go.drugbank.com/bio_entities/BE0000919TargetHumansLigand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed … Also acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels (PubMed:20228059).
Polypeptides: C-X-C chemokine receptor type 4Synonyms: SDF-1 receptor, Stromal cell-derived factor 1 receptorLow-density lipoprotein receptor-related protein 2
go.drugbank.com/bio_entities/BE0000942TargetTransporterHumansMediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). … Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity).
Polypeptides: Low-density lipoprotein receptor-related protein 2Tumor necrosis factor receptor superfamily member 5
go.drugbank.com/bio_entities/BE0001196TargetHumansReceptor for TNFSF5/CD40LG (PubMed:31331973).
Polypeptides: Tumor necrosis factor receptor superfamily member 5Synonyms: CD40L receptorProlow-density lipoprotein receptor-related protein 1
go.drugbank.com/bio_entities/BE0002110TargetHumansActs as an LRPAP1 alpha-2-macroglobulin receptor (PubMed:1702392, PubMed:26142438). … Also acts as a receptor for IGFBP3 to mediate cell growth inhibition (PubMed:9252371)
Polypeptides: Prolow-density lipoprotein receptor-related protein 1Synonyms: Apolipoprotein E receptor, Alpha-2-macroglobulin receptorGamma-aminobutyric acid receptor subunit beta-3
go.drugbank.com/bio_entities/BE0002345TargetHumansBeta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:14993607, PubMed:18514161, PubMed:22243422, PubMed:22303015, PubMed:2490...
Polypeptides: Gamma-aminobutyric acid receptor subunit beta-3Synonyms: GABA(A) receptor subunit beta-3Tumor necrosis factor receptor superfamily member 10B
go.drugbank.com/bio_entities/BE0003433TargetHumansReceptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor.
Polypeptides: Tumor necrosis factor receptor superfamily member 10BSynonyms: Death receptor 5, TRAIL receptor 2