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Displaying results 1161 - 1170 of 6949 in total
  1. Target

    Melanin-concentrating hormone receptor 1

    go.drugbank.com/bio_entities/BE0003478
    TargetHumans

    G protein-coupled receptor for melanin-concentrating hormone (MCH) that signals primarily through G(i/o) to inhibit adenylyl cyclase, and can additionally couple to G(q/11) to stimulate phospholipase C

    Polypeptides: Melanin-concentrating hormone receptor 1Synonyms: MCH receptor 1, G protein-coupled receptor 24
  2. Target

    Nuclear receptor-interacting protein 1

    go.drugbank.com/bio_entities/BE0003742
    TargetHumans

    Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transc...

    Polypeptides: Nuclear receptor-interacting protein 1Synonyms: Receptor-interacting protein 140
  3. Target

    Very low-density lipoprotein receptor

    go.drugbank.com/bio_entities/BE0004020
    TargetCarrierHumans

    Also binds to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE-containing ligands as well as clusterin/CLU (PubMed:24381170, PubMed:30873003). … Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism.

    Polypeptides: Very low-density lipoprotein receptorSynonyms: VLDL receptor
  4. Target

    Ephrin type-A receptor 7

    go.drugbank.com/bio_entities/BE0004140
    TargetHumans

    Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. … The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.

    Polypeptides: Ephrin type-A receptor 7
  5. Target

    Interleukin-1 receptor antagonist protein

    go.drugbank.com/bio_entities/BE0004735
    TargetHumans

    Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for ...

    Polypeptides: Interleukin-1 receptor antagonist protein
  6. Target

    G protein-coupled receptor 35

    go.drugbank.com/bio_entities/BE0005562
    TargetHumans

    G protein-coupled receptor that binds to several ligands including the tryptophan metabolite kynurenic acid (KYNA), lysophosphatidic acid (LPA) or 5-hydroxyindoleacetic acid (5-HIAA) with high affinity

    Polypeptides: G protein-coupled receptor 35Synonyms: KYNA receptor, Kynurenic acid receptor
  7. Target

    Orexin/Hypocretin receptor type 1

    go.drugbank.com/bio_entities/BE0005864
    TargetHumans

    In addition to G(q)-mediated signaling, orexin-A stimulation also promotes beta-arrestin recruitment, leading to receptor internalization (PubMed:15683363, PubMed:32669442). … G protein-coupled receptor that binds the neuropeptide orexin-A with high affinity, and orexin-B with lower affinity, two peptides derived from a common precursor, prepro-orexin (PubMed:32669442, PubMed

    Polypeptides: Orexin/Hypocretin receptor type 1Synonyms: Orexin receptor type 1, Hypocretin receptor type 1
  8. Target

    Corticotropin-releasing hormone receptor 1

    go.drugbank.com/bio_entities/BE0008658
    TargetHumans

    G protein-coupled receptor for CRH and UCN stress hormones, which plays a central role in whole body adaptation to stress (PubMed:18292205, PubMed:18801728, PubMed:20966082, PubMed:23576434, PubMed:23863939

    Polypeptides: Corticotropin-releasing hormone receptor 1Synonyms: Corticotropin-releasing factor receptor 1
  9. Target

    Ephrin type-A receptor 3

    go.drugbank.com/bio_entities/BE0009437
    TargetHumans

    Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. … The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (PubMed:11870224, PubMed

    Polypeptides: Ephrin type-A receptor 3Synonyms: Tyrosine-protein kinase receptor ETK1
  10. Target

    Ephrin type-A receptor 6

    go.drugbank.com/bio_entities/BE0009439
    TargetHumans

    Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. … The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity)

    Polypeptides: Ephrin type-A receptor 6