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Acid-sensing ion channel 3
go.drugbank.com/bio_entities/BE0004768TargetHumansAs a neuronal acid sensor, probably contributes to mechanoreception, acid nociception, and heat nociception (By similarity). … ASIC3 is more sensitive to protons and gates between closed, open, and desensitized states faster than other ASICs (By similarity).
Polypeptides: Acid-sensing ion channel 3Free fatty acid receptor 3
go.drugbank.com/bio_entities/BE0010132TargetHumansMay also indirectly regulate the production of LEP/Leptin, a hormone acting on the CNS to inhibit food intake, in response to the presence of short-chain fatty acids in the intestine. … In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers.
Polypeptides: Free fatty acid receptor 3Polyunsaturated fatty acid lipoxygenase ALOX12
go.drugbank.com/bio_entities/BE0012732TargetHumansCatalyzes the regio and stereo-specific incorporation of molecular oxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding … Due to its role in regulating both the expression of the vascular endothelial growth factor (VEGF, an angiogenic factor involved in the survival and metastasis of solid tumors) and the expression of integrin
Polypeptides: Polyunsaturated fatty acid lipoxygenase ALOX12Fatty-acid amide hydrolase 2
go.drugbank.com/bio_entities/BE0015331EnzymeHumanstheir corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:17015445, PubMed:19926788). … Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates
Polypeptides: Fatty-acid amide hydrolase 2Function: fatty acid amide hydrolase activityCationic amino acid transporter 4
go.drugbank.com/bio_entities/BE0000052TargetHumansInvolved in the transport of the cationic amino acids (arginine, lysine and ornithine)
Polypeptides: Cationic amino acid transporter 4Function: basic amino acid transmembrane transporter activityCationic amino acid transporter 3
go.drugbank.com/bio_entities/BE0000136TargetHumansUniporter that mediates the uptake of cationic L-amino acids such as L-arginine, L-lysine and L-ornithine (PubMed:11591158). … The transport is sodium ions- and pH-independent, moderately trans-stimulated and is mediated by passive diffusion (PubMed:11591158)
Polypeptides: Cationic amino acid transporter 3Synonyms: Cationic amino acid transporter y+Acid-sensing ion channel 1
go.drugbank.com/bio_entities/BE0000353TargetTransporterHumansRegulates more or less directly intracellular calcium concentration and CaMKII phosphorylation, and thereby the density of dendritic spines. … Upon extracellular pH drop this channel elicits transient, fast activating, and completely desensitizing inward currents (PubMed:21036899).
Polypeptides: Acid-sensing ion channel 1Acid-sensing ion channel 2
go.drugbank.com/bio_entities/BE0000678TargetHumansAdditionally, as acid sensors at nerve terminals, plays a role in mechanosensation and phototransduction (By similarity) … By forming heterotrimeric channels with ASIC1, could contribute to synaptic plasticity, learning, and memory.
Polypeptides: Acid-sensing ion channel 2Free fatty acid receptor 1
go.drugbank.com/bio_entities/BE0000688TargetHumansG protein-coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. … Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1).
Polypeptides: Free fatty acid receptor 1Excitatory amino acid transporter 2
go.drugbank.com/bio_entities/BE0000884TargetTransporterHumansMediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:14506254). … Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:14506254, PubMed:15265858, PubMed:26690923, PubMed:7521911).
Polypeptides: Excitatory amino acid transporter 2