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Granulocyte colony-stimulating factor
go.drugbank.com/bio_entities/BE0010308TargetHumansGranulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, … the granulocytes and the monocytes-macrophages.
Polypeptides: Granulocyte colony-stimulating factorProtransforming growth factor alpha
go.drugbank.com/bio_entities/BE0010380TargetHumansTGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar
Polypeptides: Protransforming growth factor alphaFunction: epidermal growth factor receptor bindingGrowth/differentiation factor 15
go.drugbank.com/bio_entities/BE0010537TargetHumansHormone produced in response to various stresses to confer information about those stresses to the brain, and trigger an aversive response, characterized by nausea, vomiting, and/or loss of appetite (PubMed … , leading to reduced appetite and weight (PubMed:31875646, PubMed:37060902).
Polypeptides: Growth/differentiation factor 15Synonyms: Prostate differentiation factorTranscription elongation factor SPT5
go.drugbank.com/bio_entities/BE0011188TargetHumansDSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). … Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630
Polypeptides: Transcription elongation factor SPT5Synonyms: DRB sensitivity-inducing factor 160 kDa subunit, DRB sensitivity-inducing factor large subunitKrueppel-like factor 4
go.drugbank.com/bio_entities/BE0011713TargetHumansTranscription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. … Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation.
Polypeptides: Krueppel-like factor 4Synonyms: Gut-enriched krueppel-like factorNucleolar transcription factor 1
go.drugbank.com/bio_entities/BE0012669TargetHumansRecognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. … It binds specifically to the upstream control element and can activate Pol I promoter escape
Polypeptides: Nucleolar transcription factor 1Synonyms: Upstream-binding factor 1Cocaine- and amphetamine-regulated transcript protein
go.drugbank.com/bio_entities/BE0000867TargetHumansSatiety factor closely associated with the actions of leptin and neuropeptide Y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced … It promotes neuronal development and survival in vitro
Polypeptides: Cocaine- and amphetamine-regulated transcript proteinMultidrug and toxin extrusion protein 1
go.drugbank.com/bio_entities/BE0003657TransporterTargetHumansPlays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively (PubMed:16330770, PubMed … Mediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate (PubMed:16330770, PubMed:17495125, PubMed:17509534, PubMed:17582384, PubMed:18305230,
Polypeptides: Multidrug and toxin extrusion protein 1Sodium- and chloride-dependent betaine transporter
go.drugbank.com/bio_entities/BE0004777TargetTransporterHumansTransporter that mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent process (PubMed:7589472). … Probably also involved in renal and hepatic osmotic regulation (By similarity)
Polypeptides: Sodium- and chloride-dependent betaine transporterHyaluronan and proteoglycan link protein 1
go.drugbank.com/bio_entities/BE0004933TargetHumansStabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix
Polypeptides: Hyaluronan and proteoglycan link protein 1