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Displaying results 111 - 120 of 5308 in total
  1. Pathway

    Citrullinemia Type I

    smpdb.ca/view/SMP0125767
    Disease

    Citrullinemia Type 1, also called argininosuccinate synthetase deficiency, argininosuccinic acid synthetase deficiency or ASS deficiency, is a rare inborn error of metabolism (IEM) and autosomal recessive

    Drugs: Pyridoxal phosphate · Pyruvic acid · Arginine · Aspartic acid · Ornithine · L-Glutamine +11 more
    Enzymes: Neutral amino acid transporter A, Neutral amino acid transporter B(0)
  2. Pathway

    Argininosuccinic Aciduria

    smpdb.ca/view/SMP0000003
    Disease

    It results in accumulation of citrulline, arginosuccinic acid, L-arginine, and L-glutamic acid in plasma as well as ammonia in blood. Infants are lethargic and unwilling to eat. … Argininosuccinic Aciduria, (Argininosuccinase Deficiency, Argininosuccinate Lyase Deficiency, ASL Deficiency) is an autosomal recessive disorder caused by a mutation in the ASL gene which codes for argininosuccinate

    Drugs: Pyridoxal phosphate · Pyruvic acid · Arginine · Aspartic acid · Ornithine · L-Glutamine +11 more
    Enzymes: Neutral amino acid transporter A, Neutral amino acid transporter B(0)
  3. Pathway

    Caffeine Nervous Action Pathway

    smpdb.ca/view/SMP0125297
    Drug action

    Caffeine is a central nervous system stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. Consistent intake of caffeine increases the population of adenosine receptors, which can poten...

    Drugs: Pyridoxal phosphate · Glutamic acid · Caffeine · Norepinephrine · Adenosine · Calcium +1 more
    Enzymes: Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit gamma-2
  4. Pathway

    Argininemia

    smpdb.ca/view/SMP0125765
    Disease

    causes accumulation of ammonia in blood; arginine, creatine, guanidinoacetate, and homoarginine in plasma; urea nitrogen in serum; arginine and homoarginine in spinal fluid; and arginiosuccinate orotic acid

    Drugs: Pyridoxal phosphate · Pyruvic acid · Arginine · Aspartic acid · Ornithine · L-Glutamine +11 more
    Enzymes: Y+L amino acid transporter 1, Neutral amino acid transporter A
  5. Pathway

    Catecholamine Biosynthesis

    smpdb.ca/view/SMP0000012
    Metabolic

    They are composed of a catechol group and are derived from amino acids. The commonly found catecholamines are epinephrine (adrenaline), norepinephrine (noradrenaline) and dopamine. … The L-DOPA is then converted to dopamine via aromatic L-amino acid decarboxylase (AADC), which becomes norepinephrine via dopamine beta-hydroxylase (DBH); and finally is converted to epinephrine via phenylethanolamine

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Tyrosine · Norepinephrine · Epinephrine +4 more
    Enzymes: Aromatic-L-amino-acid decarboxylase
  6. Pathway

    Aromatic L-Aminoacid Decarboxylase Deficiency

    smpdb.ca/view/SMP0000170
    Disease

    It also results in decreased concentrations of homovanillic acid, S-adenosylmethionine, and 5-hydroxytryptophol in spinal fluid; and epinephrine, norepinephrine in plasma.

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Tyrosine · Norepinephrine · Epinephrine +4 more
    Enzymes: Aromatic-L-amino-acid decarboxylase
  7. Pathway

    Aromatic L-Aminoacid Decarboxylase Deficiency

    smpdb.ca/view/SMP0125610
    Disease

    It also results in decreased concentrations of homovanillic acid, S-adenosylmethionine, and 5-hydroxytryptophol in spinal fluid; and epinephrine, norepinephrine in plasma.

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Tyrosine · Norepinephrine · Epinephrine +4 more
    Enzymes: Aromatic-L-amino-acid decarboxylase
  8. Pathway

    Ethosuximide Action Pathway

    smpdb.ca/view/SMP0126318
    Drug action

    Ethosuximide is an anticonvulsant used to treat petit mal seizures. It can be found under the brand name Zarontin. An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures. Used in...

    Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Ethosuximide · Calcium · Magnesium cation +3 more
    Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2
  9. Pathway

    Trimethadione Action Pathway

    smpdb.ca/view/SMP0126340
    Drug action

    Trimethadione is an anticonvulsant agent indicated for the control of treatment-refractory petit mal seizures. An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. Parameth...

    Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Trimethadione · Calcium · Magnesium cation +3 more
    Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2
  10. Pathway

    Methsuximide Action Pathway

    smpdb.ca/view/SMP0126331
    Drug action

    Methsuximide is a succinimide anticonvulsant that increases the seizure threshold. Primarily used for childhood absence seizures. Functions by suppressing paroxysmal spike-and-wave patterns associated with lapses of consciousness in abse...

    Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate +3 more
    Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2