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Displaying results 1191 - 1200 of 10000 in total
  1. Target

    Nuclear receptor coactivator 2

    go.drugbank.com/bio_entities/BE0003740
    TargetHumans

    Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108).

    Synonyms: Class E basic helix-loop-helix protein 75
  2. Target

    10 kDa heat shock protein, mitochondrial

    go.drugbank.com/bio_entities/BE0009028
    TargetHumans

    Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable) … Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins.

    Synonyms: Heat shock protein family E member 1
  3. Target

    5-aminolevulinate synthase, erythroid-specific, mitochondrial

    go.drugbank.com/bio_entities/BE0000898
    TargetHumans

    Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products (PubMed:14643893, PubMed:21252495, PubMed:21309041, PubMed:21653323, PubMed:...

    Synonyms: ALAS-E
  4. Drug

    Norethindrone enanthate

    go.drugbank.com/drugs/DB14678
    Investigational

    Mixtures: MESIGYNA®, OVUNIL®Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  5. Target

    SPARC

    go.drugbank.com/bio_entities/BE0002145
    TargetHumans

    Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites;...

    Synonyms: Secreted protein acidic and rich in cysteine
  6. Indication

    Sloughing Skin

    go.drugbank.com/conditions/DBCOND0111504
    Drugs: Phentolamine
    Synonyms: Changes in skin texture
  7. Indication

    Traveler's Diarrhea

    go.drugbank.com/conditions/DBCOND0040361
    Drugs: Azithromycin · Bismuth subsalicylate · Loperamide · Norfloxacin · Ofloxacin · Rifaximin
    Synonyms: Acute Gastroenteritis in Adult Travelers
  8. Drug

    Dextromethorphan

    go.drugbank.com/drugs/DB00514
    ApprovedInvestigational

    [A215412] Although similar in structure to other opioids, it has minimal interaction with opioid receptors.[A215412] Dextromethorphan was granted FDA approval before 3 December 1957. … Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse.

    Mixtures: Benylin All-IN-one Cold and Flu PE Caplets, Cold & Flu-IN-oneCategories: Uncompetitive N-methyl-D-aspartate Receptor Antagonist, Sigma-1 Agonist
  9. Target

    Cell growth-regulating nucleolar protein

    go.drugbank.com/bio_entities/BE0008958
    TargetMouse

    Prevents NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (PubMed:19489080). … In addition, inhibits NF-kappa-B-mediated expression of pro-inflammatory cytokines (By similarity).

    Synonyms: Protein expressed in male leptotene and zygotene spermatocytes 264
  10. Target

    Serine/threonine-protein kinase Nek3

    go.drugbank.com/bio_entities/BE0009497
    TargetHumans

    Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. … Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2

    Synonyms: Never in mitosis A-related kinase 3