Search
Celecoxib metabolism Pathway
smpdb.ca/view/SMP0000096MetabolicThis in turn inhibits the calcium-dependent events, including PLA2 activation, involved in platelet activation and aggregation. … The increase in intracellular calcium activates kinases required for morphological change, transition to the procoagulant surface, secretion of granular contents, activation of glycoproteins, and the activation
Fludarabine Action Pathway
smpdb.ca/view/SMP0126500Drug actionThis metabolite will bind and inhibit the DNA polymerase on its catalytic subunit and the ribonucleotide reductase, inhibiting DNA synthesis. … After entering the cell via the equilibration nucleoside transporter and the sodium/nucleoside cotransporter, the drug is phosphorylated to 2-fluoro-ara-A and then phosphorylated by the deoxycytidine kinase
Ibuprofen Action Pathway
smpdb.ca/view/SMP0000086Drug actionThese enzymes are available as COX1 and COX2, and are encoded by PTGS1 (COX1) and PTGS2 (COX2). … Ibuprofen is a very common NSAID drug used to treat pain and inflammation. This includes headaches, muscle pain and fever. It is sold under the brand name Advil or Motrin.
Nicotinic Acetylcholine
smpdb.ca/view/SMP0130480PhysiologicalThey are found in the central and peripheral nervous system, muscle, and many other tissues of many organisms. … In the peripheral nervous system: (1) they transmit outgoing signals from the presynaptic to the postsynaptic cells within the sympathetic and parasympathetic nervous system, and (2) they are the receptors
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Triflusal Action Pathway
smpdb.ca/view/SMP0126548Drug actionIt is indicated as prophylaxis of thromboembolic disorders (prevention of strokes and myocardial infarction). … It also acts on many other cellular targets like NF kappa B, which is a gene expression regulatory factor for cycloxygenase-a and cytokines.
Lactose Synthesis
smpdb.ca/view/SMP0000444MetabolicUDP-galactose is then transported into the Golgi by the UDP galactose translocator, an antiporter which uses facilitated transport to move UDP galactose into the Golgi and exports UMP. … Once inside the Golgi, the UDP galactose and glucose (which moves into the golgi via the GLUT-1 transporter) become substrates for the lactose synthase enzyme complex, comprised of the enzymatic subunit
Enzymes: Soluble calcium-activated nucleotidase 1Congenital Disorder of Glycosylation CDG-IId
smpdb.ca/view/SMP0000579Diseaseof oligosaccharides and their transfer. … This protein is responsible for the conversion of D-glucose and uridine diphosphategalactose to alpha-lactose and uridine 5’-diphosphate.
Enzymes: Soluble calcium-activated nucleotidase 1Dextromethorphan Nicotinic Acetylcholine Antagonism Action Pathway
smpdb.ca/view/SMP0126451Drug actionThey are present in the endoplasmic reticulum of central nervous system neurons, where they regulate calcium and potassium, but the reason for that is not well understood. … from opening and allowing sodium into the neuron.
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1GLUT-1 Deficiency Syndrome
smpdb.ca/view/SMP0000580DiseaseThis disorder is characterized by dissipation of D-glucose in both Golgi apparatus and cell cytoplasm. Symptoms of the disorder include developmental delays of mental and motor. … GLUT1 deficiency syndrome, also called GLUT1-DS or De Vivo disease, is an autosomal dominant disorder and caused by a defective solute carrier family 2, facilitated glucose transporter member 1.
Enzymes: Soluble calcium-activated nucleotidase 1Sphingolipid Metabolism
smpdb.ca/view/SMP0000034MetabolicThis forms ethanolamine phosphate and hexadecenal. … The preferred substrates for this reaction are palmitoyl-CoA and serine.