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Displaying results 121 - 130 of 138754 in total
  1. Pathway

    Medronic acid Drug Metabolism

    smpdb.ca/view/SMP0130690
    Metabolic

    Medronic acid passes through the liver and is then excreted from the body mainly through the kidney. … Medronic acid is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.

    Drugs: Medronic acid
  2. Pathway

    Alendronic acid Drug Metabolism

    smpdb.ca/view/SMP0130694
    Metabolic

    Alendronic acid passes through the liver and is then excreted from the body mainly through the kidney. … Alendronic acid is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.

    Drugs: Alendronic acid
  3. Pathway

    Ethacrynic Acid Action Pathway

    smpdb.ca/view/SMP0000097
    Drug action

    Etacrynic acid (also known as ethacrynic acid and Edecrin) is a loop diuretic that can inhibit water reabsorption by binding and inhibiting solute carrier family 12 member 1 (also known as sodium-potassium-chloride … Binding of the transporter can prevent import of sodium from lumen from loop of Henle to basolateral interstitium, which lead to more hypertonic environment in lumen than interstitium, and result in prevention

    Drugs: Cysteine · Etacrynic acid · Potassium cation · Urea
    Enzymes: Neutral and basic amino acid transport protein rBAT, Sodium- and chloride-dependent transporter XTRP3
  4. Pathway

    Mefenamic Acid Action Pathway

    smpdb.ca/view/SMP0000109
    Drug action

    Mefenamic acid can block prostaglandin synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2. … Prostaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway.

    Drugs: Glutamic acid · Glutathione · Mefenamic acid · Dinoprostone · Calcium · Magnesium cation +5 more
  5. Pathway

    Aminocaproic Acid Action Pathway

    smpdb.ca/view/SMP0000286
    Drug action

    Aminocaproic acid, brand name Amicar, is a derivate of lysine and is an antifibrinolytic drug. Antifibrinolytics drugs are commonly used during major surgery to prevent significant blood loss. … This blockade inhibits plasminogen binding to fibrin and the conversion of plasminogen to plasmin. These prevents fibrin degradation and maintains the stability of fibrin clots.

    Drugs: Aminocaproic acid · Phylloquinone · Calcium
  6. Pathway

    Valproic Acid Metabolism Pathway

    smpdb.ca/view/SMP0000635
    Drug metabolism

    Valproic acid (VPA) is metabolized almost entirely in the liver, via at least there routes: glucuronidation, beta oxidation in the mitochondria, and cytochrome P450 mediated oxidation. … The latter metabolite can furthermore be conjugated to glutathione to form thiol metabolites.

    Drugs: Adenosine phosphate · NADH · ATP · Valproic acid · Magnesium cation · Mesoheme +3 more
  7. Pathway

    Tiaprofenic Acid Action Pathway

    smpdb.ca/view/SMP0000705
    Drug action

    Prostaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway. … Tiaprofenic Acid (also named tiaprofensaeure and surgam) is a nonsteroidal anti-inflammatory drug (NSAID). It can be used to treat pain (especially arthritic pain).

    Drugs: Glutamic acid · Glutathione · Dinoprostone · Calcium · Magnesium cation · Zinc +5 more
  8. Pathway

    Lysophosphatidic Acid LPA2 Signalling

    smpdb.ca/view/SMP0063753
    Signaling

    Lysophosphatidic acid (LPA) is a water-soluble phospholipid derivative and a potent signalling molecule that binds to six known lysophosphatidic acid receptors (LPARs), named LPA1-LPA6. … LPC, LPE, LPS) into LPA via autotaxin (ATX/Enpp2) and (2) the conversion of phosphatidic acid (PA) into LPA via phospholipase A1 or A2 (PLA1/PLA2).

    Drugs: ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Lysophosphatidic acid receptor 2
  9. Pathway

    Lysophosphatidic Acid LPA4 Signalling

    smpdb.ca/view/SMP0063756
    Signaling

    Lysophosphatidic acid (LPA) is a water-soluble phospholipid derivative and a potent signalling molecule that binds to six known lysophosphatidic acid receptors (LPARs), named LPA1-LPA6. … LPC, LPE, LPS) into LPA via autotaxin (ATX/Enpp2) and (2) the conversion of phosphatidic acid (PA) into LPA via phospholipase A1 or A2 (PLA1/PLA2).

    Drugs: ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Lysophosphatidic acid receptor 4
  10. Pathway

    Mycophenolic Acid Action Pathway

    smpdb.ca/view/SMP0122722
    Drug action

    It is also possible that mycophenolic acid inhibits leukocyte recruitment to inflammation and graft rejection sites. Mycophenolic acid is administered orally in the form of a delayed release tablet. … Mycophenolic acid is a selective, reversible and potent inhibitor of the enzyme.

    Drugs: Tetrahydrofolic acid · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid · Glycine +14 more