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Displaying results 121 - 130 of 2763 in total
  1. Target

    Eukaryotic translation initiation factor 3 subunit C

    go.drugbank.com/bio_entities/BE0009239
    TargetPlasmodium falciparum (isolate 3D7)

    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates

    Polypeptides: Eukaryotic translation initiation factor 3 subunit C
  2. Target

    C-type lectin domain family 12 member A

    go.drugbank.com/bio_entities/BE0010945
    TargetHumans

    Ligand-binding induces phosphorylation of its ITIM motif, followed by recruitment of tyrosine-protein phosphatases PTPN6 and PTPN11, which counteract tyrosine-protein kinase SYK, thereby preventing myeloid … Myeloid inhibitory C-type lectin receptor that acts as a negative regulator of myeloid cell activation (PubMed:14739280, PubMed:15238421, PubMed:16239426, PubMed:34234773, PubMed:38367667, PubMed:38386511

    Polypeptides: C-type lectin domain family 12 member ASynonyms: C-type lectin-like molecule 1, Killer cell C-type lectin-like receptor L1
  3. Target

    ATP-binding cassette sub-family C member 5

    go.drugbank.com/bio_entities/BE0003639
    TransporterTargetHumans

    ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid a...

    Polypeptides: ATP-binding cassette sub-family C member 5Synonyms: Multidrug resistance-associated protein 5, MOAT-C
  4. Target

    ATP-binding cassette sub-family C member 2

    go.drugbank.com/bio_entities/BE0001069
    TargetTransporterHumans

    ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyzes ATP to enable active transport of substrates conjugated with glucuronate, glutathione or sulfate. Operates at apical membranes of polarized cells such as ...

    Polypeptides: ATP-binding cassette sub-family C member 2Synonyms: Canalicular multidrug resistance protein, Multidrug resistance-associated protein 2
  5. Target

    ATP-binding cassette sub-family C member 3

    go.drugbank.com/bio_entities/BE0001061
    TransporterHumans

    ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyzes ATP to enable active transport of substrates conjugated with glucuronate, glutathione or sulfate. Operates at basolateral membranes of polarized cells suc...

    Polypeptides: ATP-binding cassette sub-family C member 3Synonyms: Multidrug resistance-associated protein 3
  6. Target

    ATP-binding cassette sub-family C member 11

    go.drugbank.com/bio_entities/BE0003658
    TransporterHumans

    ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Plays a role in physiological processes involving bile acids, conjugated steroids and cyclic nu...

    Polypeptides: ATP-binding cassette sub-family C member 11Synonyms: Multidrug resistance-associated protein 8
  7. Target

    ATP-binding cassette sub-family C member 6

    go.drugbank.com/bio_entities/BE0003640
    TransporterTargetHumans

    ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N...

    Polypeptides: ATP-binding cassette sub-family C member 6Synonyms: Anthracycline resistance-associated protein, Multidrug resistance-associated protein 6
  8. Target

    ATP-binding cassette sub-family C member 10

    go.drugbank.com/bio_entities/BE0003651
    TransporterHumans

    ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates s...

    Polypeptides: ATP-binding cassette sub-family C member 10Synonyms: Multidrug resistance-associated protein 7
  9. Target

    Capsid protein

    go.drugbank.com/bio_entities/BE0010951
    TargetHepatitis B virus genotype A2 subtype adw2 (strain Rutter 1979)

    Most capsids appear to be large particles with an icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins … Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin

    Polypeptides: Capsid proteinSynonyms: Core protein
  10. Target

    Tyrosine-protein kinase CSK

    go.drugbank.com/bio_entities/BE0001356
    TargetHumans

    To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. … Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response.

    Polypeptides: Tyrosine-protein kinase CSKSynonyms: Protein-tyrosine kinase CYL, C-Src kinase