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Nitric Oxide Signaling Pathway
smpdb.ca/view/SMP0063777SignalingNitric oxide (NO) is a gaseous chemical transmitter that is produced from the amino acid L-arginine by the members of the NO synthase (NOS) family of proteins. The NOS family of enzymes catalyzes the oxidation of L-arginine to form L-cit...
Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps)
smpdb.ca/view/SMP0125585DiseaseBH4-deficient hyperphenylalaninemia has several causes. One such cause is a PTS deficiency resultant from a genetic mutation. (In particular, a mutation in the gene encoding 6-pyruvoyl-tetrahydropterin synthase.) The mutation is autosoma...
Hyperphenylalaninemia Due to DHPR-Deficiency
smpdb.ca/view/SMP0125586DiseaseHyperphenylalaninemia due to dihydropteridine reductase deficiency (DHPR) is the high presence of phenylalanine in the system/blood caused by a genetic mutation. More specificially, mutations in the QDPR gene are the root cause of the co...
HIF-1 (Hypoxia) Signaling
smpdb.ca/view/SMP0546631SignalingHypoxia triggers stabilization of hypoxia‑inducible factors (HIFs), oxygen‑sensitive transcription factors that orchestrate adaptive responses by inducing genes involved in angiogenesis, erythropoiesis, metabolism, and survival. Under no...
Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency
smpdb.ca/view/SMP0125583DiseaseHyperphenylalaninemia is the high presence of phenylalanine in the system/blood caused by a genetic mutation. In this case a missense error in the gene which encodes GTP cyclohydrolase. Consequently, this form of hyperphenylalaninemia is...
Amitriptyline Norepinephrine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0125187Drug actionAmitriptyline is a tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety. The non-FDA-approved indications are anxiety, post-traumatic stre...
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Amitriptyline · Sapropterin · Norepinephrine +5 moreCinnarizine H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0174985Drug actionCinnarizine is an anti-histaminic drug. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as allergic rhinitis, al...
Carbinoxamine H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0174988Drug actionCarbinoxamine is an H1-antihistamine. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as allergic rhinitis, alle...
Methapyrilene H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0175000Drug actionMethapyrilene is an H1-antihistamine. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as allergic rhinitis, alle...
Mepyramine H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0175002Drug actionMepyramine is an antihistamine agent used for the symptomatic treatment of allergy, hypersensitivity reactions, and pruritic skin disorders. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are admi...