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NAD-dependent protein deacylase sirtuin-6
go.drugbank.com/bio_entities/BE0016679TargetHumansPlays a major role in metabolism by regulating processes such as glycolysis, gluconeogenesis, insulin secretion and lipid metabolism (PubMed:24012758, PubMed:26787900).
1-phosphatidylinositol 3-phosphate 5-kinase
go.drugbank.com/bio_entities/BE0021269TargetHumansEssential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity).
Polyunsaturated fatty acid 5-lipoxygenase
go.drugbank.com/bio_entities/BE0000248TargetEnzymeHumansMay also play a role in glucose homeostasis, regulation of insulin secretion and palmitic acid-induced insulin resistance via AMPK (By similarity).
Alpha-2C adrenergic receptor
go.drugbank.com/bio_entities/BE0000342TargetHumansControl a variety of physiological processes, such as regulation of blood pressure, lipolysis and insulin release (PubMed:2842764).
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
go.drugbank.com/bio_entities/BE0000377TargetHumansPlays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion
RAC-alpha serine/threonine-protein kinase
go.drugbank.com/bio_entities/BE0000428TargetHumansPhosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling (By similarity). … Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like
5-hydroxytryptamine receptor 2C
go.drugbank.com/bio_entities/BE0000533TargetHumansPlays a role in insulin sensitivity and glucose homeostasis (By similarity)
Flavin reductase (NADPH)
go.drugbank.com/bio_entities/BE0000595TargetEnzymeHumansInhibits insulin signaling by mediating nitrosylation of INSR and IRS1, leading to their inhibition (PubMed:38056462) … Also expressed in adult tissues, where it acts as a regulator of hematopoiesis, intermediary metabolism (glutaminolysis, glycolysis, TCA cycle and pentose phosphate pathway) and insulin signaling (PubMed
Protein kinase C beta type
go.drugbank.com/bio_entities/BE0000872TargetHumansIn insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. … Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression.