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Hawkinsinuria
smpdb.ca/view/SMP0125590DiseaseHawkinsinuria (4-Hydroxyphenylpyruvate Hydroxylase Deficiency) is an autosomal dominant disease caused by a mutation in the HPD gene which codes for 4-hydroxyphenylpyruvate dioxygenase. A deficiency in this enzyme results in accumulation...
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreTyrosinemia, Transient, of the Newborn
smpdb.ca/view/SMP0000494DiseaseA transient defect in tyrosine metabolism is a common aminoacidopathy in the premature and full-term human infant. This disorder, termed neonatal tyrosinemia, was first described by Levine and Gordon in 1939. In the intervening years oth...
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreTyrosinemia, Transient, of the Newborn
smpdb.ca/view/SMP0125592DiseaseA transient defect in tyrosine metabolism is a common aminoacidopathy in the premature and full-term human infant. This disorder, termed neonatal tyrosinemia, was first described by Levine and Gordon in 1939. In the intervening years oth...
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreAlkaptonuria
smpdb.ca/view/SMP0000169DiseaseAlkaptonuria (Homogentisic acid oxidase deficiency) is an autosomal recessive disease caused by a mutation in the HGD gene which codes for homogentisate 1,2-dioxygenase. A mutation in this enzyme results in accumulation of homogentisic a...
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreHawkinsinuria
smpdb.ca/view/SMP0000190DiseaseHawkinsinuria (4-Hydroxyphenylpyruvate Hydroxylase Deficiency) is an autosomal dominant disease caused by a mutation in the HPD gene which codes for 4-hydroxyphenylpyruvate dioxygenase. A deficiency in this enzyme results in accumulation...
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreTyrosinemia Type I
smpdb.ca/view/SMP0125591DiseaseTyrosinemia type I, also known as fumarylacetoacetase or FAH deficiency, is the most severe type of tyrosinemia, a buildup of tyrosine in the body. It is caused by an autosomal recessive mutation in the the FAH gene that encodes for fuma...
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreDisulfiram Action Pathway
smpdb.ca/view/SMP0000429Drug actionDisulfiram inhibits dopamine beta-hydroxylase, which metabolizes dopamine into norepinephrine. This causes more dopamine to accumulate in the axon terminal and more dopamine is released.
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Adenosine phosphate · Tyrosine +27 moreCaffeine Vasodilation Action Pathway
smpdb.ca/view/SMP0125283Drug actionThe antagonism of adenosine A1 receptors allows more norepinephrine to be released into the synapse where it causes contractions of the heart muscles through the norepinephrine subpathway. … Adenosine A1 receptors inhibit the release of catecholamines like norepinephrine from neurons that innervate the heart muscles.
Galantamine Action Pathway (new, revision)
smpdb.ca/view/SMP0126671Drug actionIt also acts as an allosteric modulator for the neuronal acetylcholine receptor, helping control the release of neurotransmitters like acetylcholine, GABA, glutamate, dopamine, serotonin and norepinephrine
Minaprine Acetylcholinesterase Antidepressant Action Pathway
smpdb.ca/view/SMP0126689Drug actionThe first one is found in cells located in the periphery and breakdown serotonin, norepinephrine, epinephrine, dopamine, and tyramine. … The monoamine oxidase is an enzyme that catalyzes the oxidative deamination of many amines like serotonin, norepinephrine, epinephrine, and dopamine. There are 2 isoforms of this protein: A and B.