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Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
smpdb.ca/view/SMP0000321SignalingAdenosine is thought to play a role in the pathophysiology of asthma. Stimulation of A2B can induce production of interleukin-8 mast cells. The adenosine receptor A2b activates G(s) proteins which lead to the activation of adenylyl cycla...
Drugs: ATP · Adenosine · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acidMetabolism and Physiological Effects of 2-Aminobenzoic acid
smpdb.ca/view/SMP0126869DiseaseThese are benzoic acids containing an amine group attached to the benzene moiety. Within humans, 2-aminobenzoic acid participates in a number of enzymatic reactions. … Uremic syndrome may affect any part of the body and can cause nausea, vomiting, loss of appetite, and weight loss.
Enzymes: Neutral and basic amino acid transport protein rBATMetabolism and Physiological Effects of 4-Hydroxyphenylacetic acid
smpdb.ca/view/SMP0126879Metabolic, and C. propionicum. l-tyrosine, derived from diet and endogenous proteins and peptides, can be converted to phenol and 4-hydroxyphenylpyruvate. … , Klebsiella, Pseudomonas, and Proteus.
Collagen alpha-1(II) chain
go.drugbank.com/bio_entities/BE0002140TargetHumansType II collagen is specific for cartilaginous tissues. … It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces
Polypeptides: Collagen alpha-1(II) chainSynonyms: Alpha-1 type II collagenCollagen alpha-1(VII) chain
go.drugbank.com/bio_entities/BE0014000TargetHumans(ECM) proteins such as type IV collagen … Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix
Polypeptides: Collagen alpha-1(VII) chainSynonyms: LC collagen, Long-chain collagenIntracellular Signalling Through PGD2 receptor and Prostaglandin D2
smpdb.ca/view/SMP0000343SignalingPGD is the major prostanoid released from human mast cells upon immunological challenge. Prostaglandin D2 (PGD2) can trigger asthmatic responses by acting as a cell-derived mediator in mice. The PGD receptor activates G(s) proteins which...
Metabolism and Physiological Effects of Indole Acetic Acid
smpdb.ca/view/SMP0123235MetabolicAfter being transported into gut microbes, tryptophan undergoes a reaction with the enzymes tryptophan monooxygenase and indole-3-acetamide hydrolase to form indole acetic acid. … Indole acetic acid is shown to cause inflammation and disrupt the electron transport chain and oxidative phosphorylation causing muscle atrophy.
Drugs: TryptophanMetabolism and Physiological Effects of Para-cresyl glucuronide
smpdb.ca/view/SMP0123299MetabolicMost of the p-cresol that is produced from the gut microbes then enters systemic circulation and is converted into P-cresyl sulphate by the liver. … Para-cresyl glucuronide (P-cresyl glucuronide) is a phenolic compound that is formed through gut microbial metabolism from dietary tyrosine and a glucuronidation reaction in liver hepatic cells.
Metabolism and Physiological Effects of 4-Hydroxyhippuric Acid
smpdb.ca/view/SMP0125537Metabolic; nuts such as cashews, almonds, pistachios; and dairy products such as yogurt, milk, and cheese. … Benzoic acid is present in many fruits, such as apricots, prunes, and berries; many vegetables such as mushrooms (fungus), snap peas, cucumbers, and radishes; spices such as cinnamon, cloves, and allspice
Metabolism and Physiological Effects of p-Cresol sulphate
smpdb.ca/view/SMP0126850MetabolicIt has also been linked to cardiovascular disease and oxidative injury. … p-Cresol sulfate is a microbial metabolite that is found in urine and likely derives from secondary metabolism of p-cresol.