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Displaying results 131 - 140 of 606 in total
  1. Target

    Actin nucleation-promoting factor WAS

    go.drugbank.com/bio_entities/BE0002513
    TargetHumans

    Possible regulator of lymphocyte and platelet function (PubMed:9405671). … Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed:18650809).

    Polypeptides: Actin nucleation-promoting factor WAS
  2. Target

    RNA polymerase sigma factor SigA

    go.drugbank.com/bio_entities/BE0004732
    TargetClostridium difficile (strain 630)

    Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. … This sigma factor is the primary sigma factor during exponential growth.

    Polypeptides: RNA polymerase sigma factor SigA
  3. Target

    Lymphoid enhancer-binding factor 1

    go.drugbank.com/bio_entities/BE0009011
    TargetHumans

    Transcription factor that binds DNA in a sequence-specific manner (PubMed:2010090). Participates in the Wnt signaling pathway (By similarity). … TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (PubMed:11266540). Regulates T-cell receptor alpha enhancer function (PubMed:19653274).

    Polypeptides: Lymphoid enhancer-binding factor 1Synonyms: T cell-specific transcription factor 1-alpha
  4. Target

    Splicing factor 3A subunit 3

    go.drugbank.com/bio_entities/BE0009034
    TargetHumans

    Within the 17S U2 SnRNP complex, SF3A3 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic … The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA

    Polypeptides: Splicing factor 3A subunit 3
  5. Target

    Splicing factor 3B subunit 1

    go.drugbank.com/bio_entities/BE0009359
    TargetHumans

    Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). … The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA

    Polypeptides: Splicing factor 3B subunit 1Synonyms: Pre-mRNA-splicing factor SF3b 155 kDa subunit
  6. Target

    NT-3 growth factor receptor

    go.drugbank.com/bio_entities/BE0009501
    TargetHumans

    cell survival and differentiation … Receptor tyrosine kinase involved in nervous system and probably heart development.

    Polypeptides: NT-3 growth factor receptor
  7. Target

    Runt-related transcription factor 1

    go.drugbank.com/bio_entities/BE0010423
    TargetHumans

    Forms the heterodimeric complex core-binding factor (CBF) with CBFB. … CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development.

    Polypeptides: Runt-related transcription factor 1Synonyms: Core-binding factor subunit alpha-2, SL3-3 enhancer factor 1 alpha B subunit
  8. Target

    Macrophage colony-stimulating factor 1

    go.drugbank.com/bio_entities/BE0010511
    TargetHumans

    Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. … Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development.

    Polypeptides: Macrophage colony-stimulating factor 1Synonyms: Proteoglycan macrophage colony-stimulating factor
  9. Target

    Eukaryotic elongation factor 2 kinase

    go.drugbank.com/bio_entities/BE0011325
    TargetHumans

    Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive.

    Polypeptides: Eukaryotic elongation factor 2 kinaseSynonyms: Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase
  10. Target

    Transcriptional enhancer factor TEF-1

    go.drugbank.com/bio_entities/BE0013108
    TargetHumans

    Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. … The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif

    Polypeptides: Transcriptional enhancer factor TEF-1Synonyms: Transcription factor 13