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Displaying results 131 - 140 of 178 in total
  1. Target

    Catenin beta-1

    go.drugbank.com/bio_entities/BE0000985
    TargetHumans

    Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353).

  2. Target

    Long-chain-fatty-acid--CoA ligase 4

    go.drugbank.com/bio_entities/BE0000996
    TargetHumans

    Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (PubMed:21242590).

  3. Target

    Hexokinase-4

    go.drugbank.com/bio_entities/BE0001056
    TargetEnzymeHumans

    In pancreas, plays an important role in modulating insulin secretion (By similarity). … In liver, helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage (By similarity).

  4. Target

    3-phosphoinositide-dependent protein kinase 1

    go.drugbank.com/bio_entities/BE0001193
    TargetHumans

    Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation

  5. Target

    Neuroendocrine convertase 2

    go.drugbank.com/bio_entities/BE0002124
    EnzymeHumans

    Mediates the release of insulin from proinsulin (PubMed:7626024)

  6. Target

    Neuroendocrine convertase 1

    go.drugbank.com/bio_entities/BE0002125
    EnzymeHumans

    Substrates include POMC, renin, oxytocin, vasopressin, enkephalin, dynorphin, somatostatin, insulin and AGRP

  7. Target

    Vesicle-associated membrane protein 2

    go.drugbank.com/bio_entities/BE0002137
    TargetHumans

    In adipocytes, it is involved in the insulin-dependent exocytosis of GLUT4 storage vesicles (By similarity).

  8. Target

    Mitochondrial dicarboxylate carrier

    go.drugbank.com/bio_entities/BE0002261
    TransporterHumans

    Regulates fatty acid release from adipocytes, and contributes to systemic insulin sensitivity (By similarity)

  9. Target

    Serine/threonine-protein kinase mTOR

    go.drugbank.com/bio_entities/BE0002386
    TargetHumans

    The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). … May also regulate insulin signaling by acting as a tyrosine protein kinase that catalyzes phosphorylation of IGF1R and INSR; additional evidence are however required to confirm this result in vivo (PubMed

  10. Target

    Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

    go.drugbank.com/bio_entities/BE0002407
    TargetHumans

    May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required.