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Displaying results 141 - 150 of 5418 in total
  1. Target

    Glycine N-methyltransferase

    go.drugbank.com/bio_entities/BE0000372
    TargetEnzymeHumans

    Plays an important role in the regulation of methyl group metabolism by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine … Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy), a reaction regulated

  2. Target

    Thiosulfate:glutathione sulfurtransferase

    go.drugbank.com/bio_entities/BE0010200
    EnzymeHumans

    Provides the link between the first step in mammalian H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase … Thiosulfate:glutathione sulfurtransferase (TST) required to produce S-sulfanylglutathione (GSS(-)), a central intermediate in hydrogen sulfide metabolism (PubMed:24981631).

  3. Target

    Phosphatidylethanolamine N-methyltransferase

    go.drugbank.com/bio_entities/BE0020731
    EnzymeHumans

    Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine … PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine

  4. Target

    Steryl-sulfatase

    go.drugbank.com/bio_entities/BE0001197
    TargetEnzymeHumans

    Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid

  5. Target

    Squalene monooxygenase

    go.drugbank.com/bio_entities/BE0000577
    TargetEnzymeHumans

    Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis

  6. Target

    Prostacyclin receptor

    go.drugbank.com/bio_entities/BE0000475
    TargetHumans

    The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase

  7. Target

    5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

    go.drugbank.com/bio_entities/BE0001620
    TargetThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

    Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

    Function: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
  8. Target

    CAI-1 autoinducer synthase

    go.drugbank.com/bio_entities/BE0004287
    TargetVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

    Required for the synthesis of the quorum-sensing autoinducer CAI-1 ((S)-3-hydroxytridecan-4-one) which probably functions as an intragenus signal.

  9. Target

    Malonyl-CoA-acyl carrier protein transacylase, mitochondrial

    go.drugbank.com/bio_entities/BE0003812
    TargetHumans

    Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1) (PubMed:12882974, PubMed:19549604). This suggests the existence of the biosynthe...

    Function: [acyl-carrier-protein] S-malonyltransferase activity
  10. Target

    Gamma-aminobutyric acid receptor subunit gamma-3

    go.drugbank.com/bio_entities/BE0003594
    TargetHumans

    interface(s) (By similarity). … GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit