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Displaying results 141 - 150 of 358 in total
  1. Target

    Mitogen-activated protein kinase kinase kinase 20

    go.drugbank.com/bio_entities/BE0005595
    TargetHumans

    Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). … Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways

    Synonyms: Human cervical cancer suppressor gene 4 protein, Leucine zipper- and sterile alpha motif-containing kinase
  2. Target

    Linear primary-alkylsulfatase

    go.drugbank.com/bio_entities/BE0003744
    TargetPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

    Acts in vitro on primary alkylsulfates such as decyl sulfate, octyl sulfate and hexyl sulfate, but not on sulfated sugars and arylsulfates (PubMed:16684886, PubMed:23061549). … Plays a role in the degradation of both protein and carbohydrate moieties in mucin via the release of sulfate from mucin, D-galactose 6-sulfate (Gal-6S) and N-acetyl-D-glucosamine 6-sulfate (GlcNAc-6S)

    Synonyms: Type III linear primary-alkylsulfatase
  3. Target

    Cytochrome b-c1 complex subunit 1, mitochondrial

    go.drugbank.com/bio_entities/BE0001005
    TargetHumans

    The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase … May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable).

    Synonyms: Complex III subunit 1
  4. Target

    Cytochrome b-c1 complex subunit 2, mitochondrial

    go.drugbank.com/bio_entities/BE0003855
    TargetHumans

    The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase … May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable)

    Synonyms: Complex III subunit 2, Core protein II
  5. Target

    Alpha-pyrone synthesis polyketide synthase-like Pks18

    go.drugbank.com/bio_entities/BE0004239
    TargetMycobacterium tuberculosis

    Involved in the biosynthesis of tri- and tetraketide alpha-pyrones. … Pks18 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using malonyl-CoA as an extender molecule to synthesize polyketide products.

    Synonyms: Alpha-pyrone synthesis polyketide synthase type III Pks18
  6. Target

    Nitric oxide synthase 3

    go.drugbank.com/bio_entities/BE0000263
    TargetEnzymeHumans

    NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets

    Synonyms: NOS type III
  7. Target

    HLA class I histocompatibility antigen, B alpha chain

    go.drugbank.com/bio_entities/BE0004082
    TargetHumans

    Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed … Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:25808313, PubMed:29531227).

    Synonyms: Human leukocyte antigen B
  8. Target

    DNA-directed RNA polymerase II subunit RPB1

    go.drugbank.com/bio_entities/BE0010600
    TargetEnzymeHumans

    Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates … CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing.

    Polypeptides: DNA-directed RNA polymerase II subunit RPB1Synonyms: DNA-directed RNA polymerase III largest subunit, RNA polymerase II subunit B1
  9. Target

    CD44 antigen

    go.drugbank.com/bio_entities/BE0001113
    TargetHumans

    Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization … essential for cell migration and adhesion (PubMed:15123640).

    Synonyms: ECMR-III, Extracellular matrix receptor III
  10. Target

    Sodium/potassium-transporting ATPase subunit alpha-3

    go.drugbank.com/bio_entities/BE0005047
    TargetTransporterHumans

    In the brain, ATP1A3 is critical for neuronal cell signaling and for maintenance of electrochemical stability, enabling cell excitation and action potential propagation (PubMed:33880529, PubMed:36075933 … Neuron-specific alpha catalytic component of the Na(+)/K(+)-transporting ATPase, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (PubMed

    Synonyms: Na(+)/K(+) ATPase alpha(III) subunit