Search

Displaying results 141 - 150 of 198 in total
  1. Pathway

    Norepinephrine Alpha 1A Adrenergic Blood Vessel Relaxation Action Pathway

    smpdb.ca/view/SMP0125166
    Drug action

    When taken pharmacologically it acts on the sympathetic nervous system in the heart and the blood vessels. It is mainly used pharmacologically for hypotension and vasodilatory shock states. … This enzyme catalyzes Myosin light chain 3 into myosin LC-P which causes myosin to bind to actin and contract the muscle cell.

    Drugs: ATP · Norepinephrine · Calcium · Magnesium cation
  2. Pathway

    Caffeine Nervous Action Pathway

    smpdb.ca/view/SMP0125297
    Drug action

    more.Therefore arousal and wakefulness inhibits sleep, and sleep inhibits arousal and wakefullness. … Norepinephrine accumulates in the synapse and activates Alpha-1 adrenergic receptors and beta-1 adrenrgic receptors.

    Drugs: Pyridoxal phosphate · Glutamic acid · Caffeine · Norepinephrine · Adenosine · Calcium +1 more
  3. Pathway

    Tyrosinemia Type I

    smpdb.ca/view/SMP0125591
    Disease

    of tyrosine in the liver and kidneys. … Symptoms of tyrosinemia type I include jaundice and an enlarged liver, kidney dysfunction, as well as a failure to grow, as foods with high protein and amino acids lead to increased symptoms.

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 more
  4. Pathway

    Monoamine Oxidase-A Deficiency (MAO-A)

    smpdb.ca/view/SMP0125595
    Disease

    and other effects. … Since serotonin helps to regulate emotions and mood, with epinephrine and norepinephrine regulating stress, the unnecessary presence of the chemicals in the brain can lead to poor impulse control, aggression

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 more
  5. Pathway

    Tyrosine Hydroxylase Deficiency

    smpdb.ca/view/SMP0125611
    Disease

    Dopamine transmits signals to help the brain control physical movement and emotional behavior. Norepinephrine and epinephrine are involved in the autonomic nervous system. … As a result, the body produces less dopamine, norepinephrine and epinephrine. Symptoms of the disorder include abnormal movements, autonomic dysfunction, and other neurological problems.

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Tyrosine · Norepinephrine · Epinephrine +4 more
  6. Pathway

    Maprotiline Action Pathway

    smpdb.ca/view/SMP0126344
    Drug action

    Maprotiline acts as an antagonist at central presynaptic α2-adrenergic inhibitory autoreceptors and hetero-receptors, an action that is postulated to result in an increase in central noradrenergic and … This tetracyclic molecule strongly inhibits neuronal norepinephrine reuptake in the brain and peripheral tissues.

    Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Sapropterin · Norepinephrine · Maprotiline +5 more
  7. Pathway

    Nortriptyline Action Pathway

    smpdb.ca/view/SMP0126345
    Drug action

    This drug is also used off-label and it includes the treatment of chronic pain, myofascial pain, neuralgia, and irritable bowel syndrome. … Nortriptyline exerts antidepressant functions by inhibiting the reuptake of serotonin and norepinephrine in the neurons.

    Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin · Norepinephrine +7 more
  8. Pathway

    Solriamfetol Action Pathway

    smpdb.ca/view/SMP0126346
    Drug action

    Those transporters are called sodium-dependent dopamine transporter and sodium-dependent noradrenaline transporter. This makes more dopamine and noradrenaline available in the synapses of the brain. … Solriamfetol, also known as Sunosi, is a dopamine and norepinephrine reuptake inhibitor (DNRI).

    Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · ATP · Norepinephrine · Dopamine +8 more
  9. Pathway

    Desipramine Action Pathway (New)

    smpdb.ca/view/SMP0126352
    Drug action

    It binds to the sodium-dependent noradrenaline transporter and to the sodium-dependent serotonin transporter of the presynaptic neurons. … It can also be used to manage chronic neuropathic pain, as a second-line agent for the management of anxiety disorders, and as a second or third-line agent in ADHD management.

    Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin · Norepinephrine +7 more
  10. Pathway

    Atomoxetine Action Pathway (New)

    smpdb.ca/view/SMP0126353
    Drug action

    Due to atomoxetine's noradrenergic activity, it also has effects on the cardiovascular system such as increased blood pressure and tachycardia. … Although the underlying pathophysiology that causes ADHD remains undefined, evidence suggests that dysregulation in noradrenergic and dopaminergic pathways plays a critical role.

    Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Atomoxetine · Sapropterin · Norepinephrine +5 more